Zobrazeno 1 - 10
of 9 330
pro vyhledávání: '"Post-translational Modifications"'
Publikováno v:
Ibrain, Vol 10, Iss 4, Pp 427-438 (2024)
Abstract Alzheimer's disease (AD) is a neurodegenerative disease, which is mainly characterized by the abnormal deposition of β‐amyloid peptide (Aβ) and Tau. Since Tau aggregation is more closely associated with synaptic loss, neurodegeneration,
Externí odkaz:
https://doaj.org/article/668505b2086045d4969388327b3a1faa
Autor:
Yasaman Karami, Emmanuelle Bignon
Publikováno v:
Computational and Structural Biotechnology Journal, Vol 23, Iss , Pp 1387-1396 (2024)
Gene activity is tightly controlled by reversible chemical modifications called epigenetic marks, which are of various types and modulate gene accessibility without affecting the DNA sequence. Despite an increasing body of evidence demonstrating the
Externí odkaz:
https://doaj.org/article/3778777b88da441782bb2162a4dae38f
17α-Ethynylestradiol alters testicular epigenetic profiles and histone-to-protamine exchange in mice
Autor:
L. Ded, E. Zatecka-Lanska, E. Vaculikova, M. Frolikova, O. Sanovec, V. Palenikova, O. Simonik, A. Dorosh, H. Margaryan, F. Elzeinova, A. Kubatova, J. Peknicova, A. Paradowska-Dogan, K. Steger, K. Komrskova
Publikováno v:
Reproductive Biology and Endocrinology, Vol 22, Iss 1, Pp 1-13 (2024)
Abstract Spermatogenesis starts with the onset of puberty within the seminiferous epithelium of the testes. It is a complex process under intricate control of the endocrine system. Physiological regulations by steroid hormones in general and by estro
Externí odkaz:
https://doaj.org/article/de470ece8aff438a9cf6aa04af3a28ad
Autor:
Francesca Nencini, Alessandra Bettiol, Flavia Rita Argento, Serena Borghi, Elvira Giurranna, Giacomo Emmi, Domenico Prisco, Niccolò Taddei, Claudia Fiorillo, Matteo Becatti
Publikováno v:
Molecular Biomedicine, Vol 5, Iss 1, Pp 1-27 (2024)
Abstract Fibrinogen, a blood plasma protein with a key role in hemostasis and thrombosis, is highly susceptible to post-translational modifications (PTMs), that significantly influence clot formation, structure, and stability. These PTMs, which inclu
Externí odkaz:
https://doaj.org/article/e592e11f827e42dbac53eb8d481136da
Publikováno v:
Cellular & Molecular Biology Letters, Vol 29, Iss 1, Pp 1-22 (2024)
Abstract Breast cancer represents the most prevalent tumor type and a foremost cause of mortality among women globally. The complex pathophysiological processes of breast cancer tumorigenesis and progression are regulated by protein post-translationa
Externí odkaz:
https://doaj.org/article/70edaf1f8d1b487a917343567ea172f1
Publikováno v:
Beilstein Journal of Organic Chemistry, Vol 20, Iss 1, Pp 1652-1670 (2024)
This review article aims to highlight the role of methyltransferases within the context of ribosomally synthesised and post-translationally modified peptide (RiPP) natural products. Methyltransferases play a pivotal role in the biosynthesis of divers
Externí odkaz:
https://doaj.org/article/3a16fd771d7943b3893ad6752fbb83c1
Publikováno v:
Journal of Translational Medicine, Vol 22, Iss 1, Pp 1-18 (2024)
Abstract Liver cancer is a significant global health challenge, with hepatocellular carcinoma (HCC) being the most prevalent form, characterized by high incidence and mortality rates. Despite advances in targeted therapies and immunotherapies, the pr
Externí odkaz:
https://doaj.org/article/52687e5a483b44188bdff0f44927059a
Publikováno v:
Journal of Inflammation Research, Vol Volume 17, Pp 4315-4330 (2024)
Chenguang Jia,1,* Xiaowei Yao,1,* Zhaoliang Dong,1 Lianbo Wang,1 Fangchao Zhao,2,* Jianguo Gao,1,* Tao Cai3,* 1Department of Orthopedics, Hebei Chest Hospital, Shijiazhuang, Hebei, People’s Republic of China; 2Department of Thor
Externí odkaz:
https://doaj.org/article/02929106a75142e4bd53ac33b1cc097e
Publikováno v:
Molecular Therapy: Oncology, Vol 32, Iss 4, Pp 200871- (2024)
Some cancer types including bladder, cervical, and uterine cancers are characterized by frequent mutations in EP300 that encode histone acetyltransferase p300. This enzyme can act both as a tumor suppressor and oncogene. In this review, we describe t
Externí odkaz:
https://doaj.org/article/934477f217924601903f7da4ed026ea1
Publikováno v:
Nucleus, Vol 15, Iss 1 (2024)
Promyelocytic leukemia (PML) nuclear bodies, membrane-less organelles in the nucleus, play a crucial role in cellular homeostasis. These dynamic structures result from the assembly of scaffolding PML proteins and various partners. Recent crystal stru
Externí odkaz:
https://doaj.org/article/fc736dc7be794c4d825557f50abfb0e7