Structural and functional prediction, evaluation, and validation in the post-sequencing era

Autor: Chang Li, Yixuan Luo, Yibo Xie, Zaifeng Zhang, Ye Liu, Lihui Zou, Fei Xiao

Publikováno v: Computational and Structural Biotechnology Journal, Vol 23, Iss , Pp 446-451 (2024)

The surge of genome sequencing data has underlined substantial genetic variants of uncertain significance (VUS). The decryption of VUS discovered by sequencing poses a major challenge in the post-sequencing era. Although experimental assays have prog

Externí odkaz: https://doaj.org/article/ff2abe6194e1426295abe653a55d1cea

Structural and functional prediction, evaluation, and validation in the post-sequencing era.

Autor: Li C; Clinical Biobank, Beijing Hospital, National Center of Gerontology, National Health Commission, Institute of Geriatric Medicine, Chinese Academy of Medical Sciences, Beijing, China.; The Key Laboratory of Geriatrics, Beijing Institute of Geriatrics, Beijing Hospital, National Center of Gerontology, National Health Commission, Institute of Geriatric Medicine, Chinese Academy of Medical Sciences, Beijing, China., Luo Y; Beijing Normal University, Beijing, China., Xie Y; Information Center, Beijing Hospital, National Center of Gerontology, National Health Commission, Institute of Geriatric Medicine, Chinese Academy of Medical Sciences, Beijing, China., Zhang Z; The Key Laboratory of Geriatrics, Beijing Institute of Geriatrics, Beijing Hospital, National Center of Gerontology, National Health Commission, Institute of Geriatric Medicine, Chinese Academy of Medical Sciences, Beijing, China., Liu Y; The Key Laboratory of Geriatrics, Beijing Institute of Geriatrics, Beijing Hospital, National Center of Gerontology, National Health Commission, Institute of Geriatric Medicine, Chinese Academy of Medical Sciences, Beijing, China., Zou L; The Key Laboratory of Geriatrics, Beijing Institute of Geriatrics, Beijing Hospital, National Center of Gerontology, National Health Commission, Institute of Geriatric Medicine, Chinese Academy of Medical Sciences, Beijing, China., Xiao F; Clinical Biobank, Beijing Hospital, National Center of Gerontology, National Health Commission, Institute of Geriatric Medicine, Chinese Academy of Medical Sciences, Beijing, China.; The Key Laboratory of Geriatrics, Beijing Institute of Geriatrics, Beijing Hospital, National Center of Gerontology, National Health Commission, Institute of Geriatric Medicine, Chinese Academy of Medical Sciences, Beijing, China.; Beijing Normal University, Beijing, China.

Publikováno v: Computational and structural biotechnology journal [Comput Struct Biotechnol J] 2023 Dec 25; Vol. 23, pp. 446-451. Date of Electronic Publication: 2023 Dec 25 (Print Publication: 2024).