Zobrazeno 1 - 10
of 199
pro vyhledávání: '"Post-GWAS"'
Autor:
Natasha K. Tuano, Jonathan Beesley, Murray Manning, Wei Shi, Laura Perlaza-Jimenez, Luis F. Malaver-Ortega, Jacob M. Paynter, Debra Black, Andrew Civitarese, Karen McCue, Aaron Hatzipantelis, Kristine Hillman, Susanne Kaufmann, Haran Sivakumaran, Jose M. Polo, Roger R. Reddel, Vimla Band, Juliet D. French, Stacey L. Edwards, David R. Powell, Georgia Chenevix-Trench, Joseph Rosenbluh
Publikováno v:
Genome Biology, Vol 24, Iss 1, Pp 1-23 (2023)
Abstract Background Genome-wide association studies (GWAS) have identified > 200 loci associated with breast cancer risk. The majority of candidate causal variants are in non-coding regions and likely modulate cancer risk by regulating gene expressio
Externí odkaz:
https://doaj.org/article/6fa5b74012424fbe8ef3072e8a09b991
Autor:
Stephen Burgess, Ting Ye, Ashish Patel, Zhaotong Lin, Amy M. Mason, Haoran Xue, Benjamin Woolf, Siqi Xu
Publikováno v:
Wellcome Open Research, Vol 8 (2023)
The MendelianRandomization package is a software package written for the R software environment that implements methods for Mendelian randomization based on summarized data. In this manuscript, we describe functions that have been added or edited in
Externí odkaz:
https://doaj.org/article/927cd9a1cadf4a719b63543beb74ceba
Autor:
Stephen Burgess, Ting Ye, Ashish Patel, Zhaotong Lin, Amy M. Mason, Haoran Xue, Benjamin Woolf, Siqi Xu
Publikováno v:
Wellcome Open Research, Vol 8 (2023)
The MendelianRandomization package is a software package written for the R software environment that implements methods for Mendelian randomization based on summarized data. In this manuscript, we describe functions that have been added or edited in
Externí odkaz:
https://doaj.org/article/bf0bfe9a59d047a7addc6d01ce516fed
Autor:
Guoping Shu, Aifang Wang, Xingchuan Wang, Junqiang Ding, Ruijie Chen, Fei Gao, Aifen Wang, Ting Li, Yibo Wang
Publikováno v:
Frontiers in Plant Science, Vol 14 (2023)
Southern corn rust (SCR) caused by Puccinia polysora Underw is a major disease leading to severe yield losses in China Summer Corn Belt. Using six multi-locus GWAS methods, we identified a set of SCR resistance QTNs from a diversity panel of 140 inbr
Externí odkaz:
https://doaj.org/article/1ef8bb2fb16846f18972299d4ea14d41
Autor:
Rotimi Solomon, Gordon Wells, Benedikt Brors, Emmanuel Adetiba, Yagoub Adam, Ezekiel Adebiyi, Olabode Ajayi, Suraju Sadeeq, Olubanke Ogunlana, Judit Kumuthini, Emeka Iweala
Publikováno v:
F1000Research, Vol 11 (2023)
Polygenic Risk Score (PRS) analysis is a method that predicts the genetic risk of an individual towards targeted traits. Even when there are no significant markers, it gives evidence of a genetic effect beyond the results of Genome-Wide Association S
Externí odkaz:
https://doaj.org/article/14757a763eb148efb4ae84ba53808582
Publikováno v:
Frontiers in Genetics, Vol 14 (2023)
Genome-wide association study (GWAS) have identified over 1,000 loci associated with blood pressure. However, these loci only explain 6% of heritability. Transcriptome-wide association studies (TWAS) combine GWAS summary data with expression quantita
Externí odkaz:
https://doaj.org/article/cb339d9d5fce4337b644c58abe74f504
Publikováno v:
Frontiers in Genetics, Vol 13 (2022)
Our knowledge of complex disorders has increased in the last years thanks to the identification of genetic variants (GVs) significantly associated with disease phenotypes by genome-wide association studies (GWAS). However, we do not understand yet ho
Externí odkaz:
https://doaj.org/article/7b74157caa9c48559e25ce327791f8c9
Akademický článek
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Akademický článek
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Autor:
Uhl, George R., Martinez, Maria J., Paik, Paul, Sulima, Agnieszka, Bi, Guo-Hua, Iyer, Malliga R., Gardner, Eliot, Rice, Kenner C., Xi, Zheng-Xiong
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America, 2018 Nov 01. 115(45), 11597-11602.
Externí odkaz:
https://www.jstor.org/stable/26563188