Zobrazeno 1 - 5
of 5
pro vyhledávání: '"Poss Kathleen M"'
Autor:
Liesl G. Fisher, P.J. McCann, D.A. Young, C.M. Arbeeny, S. Skwish, Amarendra B. Mikkilineni, Poss Kathleen M, G.T. Allen, Chongqing Sun, Michael Cap, R.J. George, Dorothy Slusarchyk, B.E. Abboa-Offei, Ravindar N. Girotra, William N. Washburn, Carl P. Ciosek, A.V. Gavai, Belay Tesfamariam, T.W. Harper, Ginger Wu, B.H. Frohlich, D.E. Hillyer, Tammy C. Wang, A A Seymour, Mark S. Bednarz, Philip M. Sher, Kenneth E.J. Dickinson, T.L. Waldron, Arvind Mathur
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 11:3041-3044
A series of 4-hydroxy-3-methylsulfonanilido-1,2-diarylethylamines were prepared and evaluated for their human beta(3) adrenergic receptor agonist activity. SAR studies led to the identification of BMS-196085 (25), a potent beta(3) full agonist (K(i)=
Autor:
Sam T. Chao, Sarah C. Traeger, P.J. McCann, William N. Washburn, Varma Ravi K, Poss Kathleen M, Eric M. Gordon, Dinos Santafianos
Publikováno v:
Tetrahedron Letters. 35:3461-3464
The synthesis and diastereoselective oxidation of novel tetrahydromevinic acid lactone sulfides to sulfoxides is described.
Autor:
Eric M. Gordon, Dinos Santafianos, Varma Ravi K, Sarah C. Traeger, William N. Washburn, Sam T. Chao, Poss Kathleen M, P.J. McCann
Publikováno v:
ChemInform. 25
The synthesis and diastereoselective oxidation of novel tetrahydromevinic acid lactone sulfides to sulfoxides is described.
Autor:
Z. Merchant, S. Skwish, Dorothy Slusarchyk, P.J. McCann, D.A. Young, M. Morella, Kenneth E.J. Dickinson, Michael Cap, Ravindar N. Girotra, Anita D. Russell, B.E. Abboa-Offei, William N. Washburn, G.T. Allen, A.V. Gavai, Belay Tesfamariam, Peter T. W. Cheng, G. S. Bisacchi, Tammy C. Wang, A A Seymour, T.W. Harper, C.M. Arbeeny, Tamara Dejneka, Amarendra B. Mikkilineni, Poss Kathleen M, Chongqing Sun, Philip M. Sher, T.L. Waldron, R.J. George, B.H. Frohlich, Ginger Wu, Denis E. Ryono
Publikováno v:
Bioorganicmedicinal chemistry letters. 14(13)
A series of N-(4-hydroxy-3-methylsulfonanilidoethanol)arylglycinamides were prepared and evaluated for their human β3 adrenergic receptor agonist activity. SAR studies led to the identification of BMS-201620 (39), a potent β3 full agonist (Ki=93 nM
Autor:
Kenneth E.J. Dickinson, Michael Cap, Peter T. W. Cheng, A.V. Gavai, Arvind Mathur, Belay Tesfamariam, G.T. Allen, T.W. Harper, D.E. Hillyer, Tamara Dejneka, Dorothy Slusarchyk, S. Skwish, P.J. McCann, Chongqing Sun, Richard E. Gregg, D.A. Young, Carl P. Ciosek, Tammy C. Wang, Ravindar N. Girotra, Philip M. Sher, B.E. Abboa-Offei, A A Seymour, William N. Washburn, C.M. Arbeeny, Amarendra B. Mikkilineni, Poss Kathleen M, T.L. Waldron, R.J. George, B.H. Frohlich, Anita D. Russell, Denis E. Ryono
Publikováno v:
Bioorganicmedicinal chemistry letters. 11(23)
Screening of the BMS collection identified 4-hydroxy-3-methylsulfonanilidoethanolamines as full beta 3 agonists. Substitution of the ethanolamine nitrogen with a benzyl group bearing a para hydrogen bond acceptor promoted beta(3) selectivity. SAR elu