GSK2245035, a TLR7 agonist, Does Not Increase Pregnancy Loss in Cynomolgus Monkeys

Autor: Posobiec, LM ^*, Hillegas, AE, Baker, A, Phadnis-Moghe, AS, Maier, CC, Stanislaus, DJ, Bray, M, Price, MA

Publikováno v: In Journal of Reproductive Immunology February 2021 143

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Novel Bacterial Topoisomerase Inhibitor Gepotidacin Demonstrates Absence of Fluoroquinolone-Like Arthropathy in Juvenile Rats.

Autor: Fishman C; Nonclinical Safety, GSK Research and Development, Collegeville, Pennsylvania, USA., Caverly Rae JM; Nonclinical Safety, GSK Research and Development, Collegeville, Pennsylvania, USA., Posobiec LM; Nonclinical Safety, GSK Research and Development, Collegeville, Pennsylvania, USA., Laffan SB; Nonclinical Safety, GSK Research and Development, Collegeville, Pennsylvania, USA., Lerman SA; Nonclinical Safety, GSK Research and Development, Collegeville, Pennsylvania, USA., Pearson N; Medicinal Chemistry, GSK Research and Development, Collegeville, Pennsylvania, USA., Janmohamed S; Clinical Sciences, GSK Research and Development, Brentford, Middlesex, United Kingdom., Dumont E; Clinical Sciences, GSK Research and Development, Collegeville, Pennsylvania, USA., Nunn-Floyd D; Nonclinical Safety, GSK Research and Development, Collegeville, Pennsylvania, USA., Stanislaus DJ; Nonclinical Safety, GSK Research and Development, Collegeville, Pennsylvania, USA.

Publikováno v: Antimicrobial agents and chemotherapy [Antimicrob Agents Chemother] 2022 Nov 15; Vol. 66 (11), pp. e0048322. Date of Electronic Publication: 2022 Oct 18.

Letter to the editor in re: Mohan et al., 2020 'dolutegravir in pregnant mice is associated with increased rates of fetal defects at therapeutic but not at supratherapeutic levels'.

Autor: Romach EH; Viiv Healthcare, RTP, NC, USA. Electronic address: beth.h.romach@viivhealthcare.com., Posobiec LM; GlaxoSmithKline, Collegeville, PA, USA., Bloomer JC; GlaxoSmithKline, Ware, UK., Zamek-Gliszczynski MJ; GlaxoSmithKline, Collegeville, PA, USA., Stanislaus DJ; GlaxoSmithKline, Collegeville, PA, USA.

Publikováno v: EBioMedicine [EBioMedicine] 2021 Apr; Vol. 66, pp. 103335. Date of Electronic Publication: 2021 Apr 12.

Repeated Dose Toxicity Study and Developmental and Reproductive Toxicology Studies of a Respiratory Syncytial Virus Candidate Vaccine in Rabbits and Rats.

Autor: Stokes AH; GSK, Rockville, MD, USA., Franklin K; 201915Covance Laboratories Inc., Greenfield, IN, USA., Fisher DE; Charles River Laboratories, Horsham, PA, USA., Posobiec LM; 33139GSK, Collegeville, PA, USA., Binazon O; 33139GSK, Wavre, Belgium., Tripathi N; 201915Covance Laboratories Inc, Madison, WI, USA., Ringenberg MA; 33139GSK, Collegeville, PA, USA., Charlap J; Charles River Laboratories, Horsham, PA, USA.; Current affiliation: Chevron, San Ramon, CA, USA., Ziejewski MK; 33139GSK, Collegeville, PA, USA., Vemireddi V; 201915Covance Laboratories Inc, Chantilly, VA, USA., Khanna Weiss P; 201915Covance Laboratories Inc, Chantilly, VA, USA.; Current affiliation: DEFTEC Corporation, Inc., Chantilly, VA ,USA., Majumdar R; 201915Covance Laboratories Inc, Chantilly, VA, USA., Bouzya B; 33139GSK, Rixensart, Belgium., Donner MN; 33139GSK, Rixensart, Belgium., Rodriguez LA; 33139GSK, Wavre, Belgium., Baumeister J; 33139GSK, Wavre, Belgium.; Current affiliation: ArgenX, Belgium.

Publikováno v: International journal of toxicology [Int J Toxicol] 2021 Mar-Apr; Vol. 40 (2), pp. 125-142. Date of Electronic Publication: 2021 Feb 01.