Regulated induced proximity targeting chimeras-RIPTACs-A heterobifunctional small molecule strategy for cancer selective therapies.

Autor: Raina K; Halda Therapeutics OpCo Inc, New Haven, CT, USA., Forbes CD; Halda Therapeutics OpCo Inc, New Haven, CT, USA., Stronk R; Halda Therapeutics OpCo Inc, New Haven, CT, USA., Rappi JP Jr; Halda Therapeutics OpCo Inc, New Haven, CT, USA., Eastman KJ; Halda Therapeutics OpCo Inc, New Haven, CT, USA., Zaware N; Halda Therapeutics OpCo Inc, New Haven, CT, USA., Yu X; Halda Therapeutics OpCo Inc, New Haven, CT, USA., Li H; Halda Therapeutics OpCo Inc, New Haven, CT, USA., Bhardwaj A; Halda Therapeutics OpCo Inc, New Haven, CT, USA., Gerritz SW; Halda Therapeutics OpCo Inc, New Haven, CT, USA., Forgione M; Halda Therapeutics OpCo Inc, New Haven, CT, USA., Hundt A; Halda Therapeutics OpCo Inc, New Haven, CT, USA., King MP; Halda Therapeutics OpCo Inc, New Haven, CT, USA., Posner ZM; Halda Therapeutics OpCo Inc, New Haven, CT, USA., Correia AD; Halda Therapeutics OpCo Inc, New Haven, CT, USA., McGovern A; Halda Therapeutics OpCo Inc, New Haven, CT, USA., Puleo DE; Halda Therapeutics OpCo Inc, New Haven, CT, USA., Chenard R; Halda Therapeutics OpCo Inc, New Haven, CT, USA., Mousseau JJ; Halda Therapeutics OpCo Inc, New Haven, CT, USA., Vergara JI; Department of Molecular, Cellular, & Developmental Biology, Yale University, New Haven, CT, USA., Garvin E; Halda Therapeutics OpCo Inc, New Haven, CT, USA., Macaluso J; Halda Therapeutics OpCo Inc, New Haven, CT, USA., Martin M; Halda Therapeutics OpCo Inc, New Haven, CT, USA., Bassoli K; Halda Therapeutics OpCo Inc, New Haven, CT, USA., Jones K; Halda Therapeutics OpCo Inc, New Haven, CT, USA., Garcia M; Halda Therapeutics OpCo Inc, New Haven, CT, USA., Howard K; Halda Therapeutics OpCo Inc, New Haven, CT, USA., Yaggi M; Halda Therapeutics OpCo Inc, New Haven, CT, USA., Smith LM; Halda Therapeutics OpCo Inc, New Haven, CT, USA., Chen JM; Halda Therapeutics OpCo Inc, New Haven, CT, USA., Mayfield AB; Department of Molecular, Cellular, & Developmental Biology, Yale University, New Haven, CT, USA., De Leon CA; Department of Molecular, Cellular, & Developmental Biology, Yale University, New Haven, CT, USA., Hines J; Department of Molecular, Cellular, & Developmental Biology, Yale University, New Haven, CT, USA., Kayser-Bricker KJ; Halda Therapeutics OpCo Inc, New Haven, CT, USA. Electronic address: kat.kayser-bricker@haldathera.com., Crews CM; Department of Molecular, Cellular, & Developmental Biology, Yale University, New Haven, CT, USA; Department of Pharmacology, Yale University, New Haven, CT, USA; Department of Chemistry, Yale University, New Haven, CT, USA. Electronic address: craig.crews@yale.edu.

Publikováno v: Cell chemical biology [Cell Chem Biol] 2024 Aug 15; Vol. 31 (8), pp. 1490-1502.e42. Date of Electronic Publication: 2024 Aug 07.