Zobrazeno 1 - 10
of 79
pro vyhledávání: '"Positive transcription elongation factor b"'
Autor:
Simona Krasnopolsky, Lital Marom, Rachel A. Victor, Alona Kuzmina, Jacob C. Schwartz, Koh Fujinaga, Ran Taube
Publikováno v:
Retrovirology, Vol 16, Iss 1, Pp 1-19 (2019)
Abstract Background The human immunodeficiency virus (HIV) cell reservoir is currently a main obstacle towards complete eradication of the virus. This infected pool is refractory to anti-viral therapy and harbors integrated proviruses that are transc
Externí odkaz:
https://doaj.org/article/713a51bffa35458d803d3907929cb896
Publikováno v:
Journal of Experimental & Clinical Cancer Research, Vol 37, Iss 1, Pp 1-10 (2018)
Abstract Current treatment for acute myeloid leukemia (AML) is less than optimal, but increased understanding of disease pathobiology and genomics has led to clinical investigation of novel targeted therapies and rational combinations. Targeting the
Externí odkaz:
https://doaj.org/article/f4ba7ae22b094ca89d4f67a1d853376c
Autor:
V. M. Merkulov, T. I. Merkulova
Publikováno v:
Вавиловский журнал генетики и селекции, Vol 18, Iss 2, Pp 329-337 (2015)
Sequence-specific (regulatory) transcription factors selectively regulate the transcription levels of different sets of eukaryotic genes depending on cell type, developmental stage, and external signals. Recruitment of the RNA-polymerase II transcrip
Externí odkaz:
https://doaj.org/article/89a30f78b73f4b18a8a2edf973af5205
Publikováno v:
Acta Pharmaceutica Sinica B, Vol 11, Iss 2, Pp 309-321 (2021)
Acta Pharmaceutica Sinica. B
Acta Pharmaceutica Sinica. B
Cullin-RING ligases (CRLs) recognize and interact with substrates for ubiquitination and degradation, and can be targeted for disease treatment when the abnormal expression of substrates involves pathologic processes. Phosphorylation, either of subst
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f27b7f488f3a53677836e1b8e5b2722d
https://doi.org/10.1016/j.apsb.2020.09.007
https://doi.org/10.1016/j.apsb.2020.09.007
Autor:
Matija Peterlin, Ran Taube
Publikováno v:
Viruses, Vol 5, Iss 3, Pp 902-927 (2013)
Highly active antiretroviral therapy (HAART) has limited the replication and spread of the human immunodeficiency virus (HIV). However, despite treatment, HIV infection persists in latently infected reservoirs, and once therapy is interrupted, viral
Externí odkaz:
https://doaj.org/article/ab8b43c076b847e1a88a0c314901a6aa
Autor:
Amit Singh, Ballachanda N. Devaiah, Dinah S. Singer, Jocelyn D. Weissman, Ross C. Larue, Peter Schuck
Publikováno v:
The Journal of Biological Chemistry
Bromodomain protein 4 (BRD4) is a transcriptional and epigenetic regulator that is a therapeutic target in many cancers and inflammatory diseases. BRD4 plays important roles in transcription as an active kinase, which phosphorylates the carboxy-termi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::acb6e26f25e292e91d4313135fd65dec
https://pubmed.ncbi.nlm.nih.gov/34688663
https://pubmed.ncbi.nlm.nih.gov/34688663
Autor:
Alona Kuzmina, Simona Krasnopolsky, Lital Marom, Ran Taube, Rachel A. Victor, Koh Fujinaga, Jacob C. Schwartz
Publikováno v:
Retrovirology, Vol 16, Iss 1, Pp 1-19 (2019)
Retrovirology
Retrovirology
Background The human immunodeficiency virus (HIV) cell reservoir is currently a main obstacle towards complete eradication of the virus. This infected pool is refractory to anti-viral therapy and harbors integrated proviruses that are transcriptional
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ae00da4b3d5c49d164bed9abf40a3ee4
http://link.springer.com/article/10.1186/s12977-019-0478-x
http://link.springer.com/article/10.1186/s12977-019-0478-x
Publikováno v:
The Journal of Biological Chemistry
The concept of liquid–liquid phase separation (LLPS) has emerged as an intriguing mechanism for the organization of membraneless compartments in cells. The alcohol 1,6-hexanediol is widely used as a control to dissolve LLPS assemblies in phase sepa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7969621984bc4a26a43efd29a43fdb29
https://pubmed.ncbi.nlm.nih.gov/33814344
https://pubmed.ncbi.nlm.nih.gov/33814344
Autor:
Landon Long Chan, Lina Zhu, Siu Yuen Chan, Yi Ching Esther Wan, Dongbo Ding, Qing Li, Jiaxian Liu, Saravanan Ramakrishnan, Kui Ming Chan, Haiyun Gan, Xiaoxuan Zhu, Tze Zhen Evangeline Kang, Xin Wang, Junhong Han, Du Yang, Toyotaka Ishibashi
Publikováno v:
The Journal of Biological Chemistry
The recent discovery of the cancer-associated E76K mutation in histone H2B (H2BE76-to-K) in several types of cancers revealed a new class of oncohistone. H2BE76K weakens the stability of histone octamers, alters gene expression, and promotes colony f
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4a7f8d7a3310125c3d36d27388f41b77
https://pubmed.ncbi.nlm.nih.gov/33548228
https://pubmed.ncbi.nlm.nih.gov/33548228
Akademický článek
Tento výsledek nelze pro nepřihlášené uživatele zobrazit.
K zobrazení výsledku je třeba se přihlásit.
K zobrazení výsledku je třeba se přihlásit.