Zobrazeno 1 - 10
of 782
pro vyhledávání: '"Positive feedback loop"'
Autor:
Hui Qiu, Zhiying Shao, Xin Wen, Debao Qu, Zhengyang Liu, Ziqin Chen, Xinyan Zhang, Xin Ding, Longzhen Zhang
Publikováno v:
Journal of Translational Medicine, Vol 22, Iss 1, Pp 1-19 (2024)
Abstract Background Radioresistance and immune escape are crucial reasons for unsatisfactory therapeutic effects of glioblastoma (GBM). Although triggering receptor expressed on myeloid cells-2 (TREM2) involved in forming immunosuppressive microenvir
Externí odkaz:
https://doaj.org/article/ffc87da269e343c58f8c0d16862670bf
Autor:
Feng Xiao, Hong Zhu, Yaping Xiong, Yun Guo, Zhe Zhang, Jie Zeng, Yao Xiao, Bin Liao, Xuesong Shang, Siyi Zhao, Guowen Hu, Kai Huang, Hua Guo
Publikováno v:
Journal of Experimental & Clinical Cancer Research, Vol 43, Iss 1, Pp 1-19 (2024)
Abstract Background Recent studies have highlighted the significant role of the NF-κB signaling pathway in the initiation and progression of cancer. Furthermore, long noncoding RNAs (lncRNAs) have been identified as pivotal regulators in sustaining
Externí odkaz:
https://doaj.org/article/c1ff45ab488c4edbb8d397555e56b8fc
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-9 (2024)
Abstract In this study, a binarized neural network (BNN) of silicon diode arrays achieved vector–matrix multiplication (VMM) between the binarized weights and inputs in these arrays. The diodes that operate in a positive-feedback loop in their p+-n
Externí odkaz:
https://doaj.org/article/83756f46aba04eaaa245de1f3c194208
Publikováno v:
Nonlinear Analysis, Vol 29, Iss 4 (2024)
In this paper, we employ computational analysis to investigate the long-term potentiation (LTP) and memory formation in synapses between neurons. We use a mathematical model describing the synaptic transmission as a signal transduction pathway with a
Externí odkaz:
https://doaj.org/article/2400b9418739432cbc9b2159993e3d79
Autor:
Ran Liu, Chuanzheng Yin, Peng Zhao, Bing Guo, Wenbo Ke, Xichuan Zheng, Dawei Xie, Yaofeng Wang, Gengqiao Wang, Yinzhao Jia, Yang Gao, Wenjun Hu, Gang Logan Liu, Zifang Song
Publikováno v:
Biology Direct, Vol 18, Iss 1, Pp 1-20 (2023)
Abstract Background Nuclear respiratory factor 1 (NRF1) is a transcription factor that participates in several kinds of tumor, but its role in hepatocellular carcinoma (HCC) remains elusive. This study aims to explore the role of NRF1 in HCC progress
Externí odkaz:
https://doaj.org/article/e635c01c6d284aeb851bb10e8042d600
Autor:
Yuanlong Li, Yao Kong, Mingjie An, Yuming Luo, Hanhao Zheng, Yan Lin, Jiancheng Chen, Jin Yang, Libo Liu, Baoming Luo, Jian Huang, Tianxin Lin, Changhao Chen
Publikováno v:
Journal of Experimental & Clinical Cancer Research, Vol 42, Iss 1, Pp 1-16 (2023)
Abstract Background Circular RNAs (circRNAs) circularized by back-splicing of pre-mRNA are widely expressed and affected the proliferation, invasion and metastasis of bladder cancer (BCa). However, the mechanism underlying circRNA biogenesis in media
Externí odkaz:
https://doaj.org/article/e067216a49514e58acdc47610a19ae0e
Publikováno v:
Cancer Biology & Therapy, Vol 24, Iss 1 (2023)
Background The function of long non-coding RNA (lncRNA) MALAT1 in regulating triple-negative breast cancer (TNBC) stemness and tumorigenesis was investigated. Methods Sphere formation and colony formation assays coupled with flow cytometry were emplo
Externí odkaz:
https://doaj.org/article/b48d8bf29c4c433988e83f1a069d65dc
Autor:
Jiabing Zhan, Kunying Jin, Nan Ding, Yufei Zhou, Guo Hu, Shuai Yuan, Rong Xie, Zheng Wen, Chen Chen, Huaping Li, Dao Wen Wang
Publikováno v:
Molecular Therapy: Nucleic Acids, Vol 31, Iss , Pp 122-138 (2023)
Intensive glycemic control is insufficient for reducing the risk of heart failure among patients with diabetes mellitus (DM). While the “hyperglycemic memory” phenomenon is well documented, little is known about its underlying mechanisms. In this
Externí odkaz:
https://doaj.org/article/7d2b361c7929414b86910bf39428dc5c