Zobrazeno 1 - 10
of 19
pro vyhledávání: '"Poshen B Chen"'
Publikováno v:
PLoS Computational Biology, Vol 16, Iss 9, p e1008194 (2020)
CRISPR screens are a powerful technology for the identification of genome sequences that affect cellular phenotypes such as gene expression, survival, and proliferation. By targeting non-coding sequences for perturbation, CRISPR screens have the pote
Externí odkaz:
https://doaj.org/article/6b5fc805c7904a6d889d978e145c263d
Autor:
Poshen B Chen, Jui-Hung Hung, Taylor L Hickman, Andrew H Coles, James F Carey, Zhiping Weng, Feixia Chu, Thomas G Fazzio
Publikováno v:
eLife, Vol 2 (2013)
In embryonic stem cells (ESCs), the Tip60 histone acetyltransferase activates genes required for proliferation and silences genes that promote differentiation. Here we show that the class II histone deacetylase Hdac6 co-purifies with Tip60-p400 compl
Externí odkaz:
https://doaj.org/article/08747d585bf3462b92cf9bb0d544ea81
Autor:
Mien-Chie Hung, Michael Hsiao, Xiaoyun Cheng, Yi-Hua Jan, Yi-Wen Chang, Shang-Chih Chen, Ya-Huey Chen, Poshen B. Chen, Jen-Liang Su
Supplementary Figures 1-7 from Downregulation of MicroRNA miR-520h by E1A Contributes to Anticancer Activity
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::99a0d7add2747932988a48044a3f33e5
https://doi.org/10.1158/0008-5472.22383258.v1
https://doi.org/10.1158/0008-5472.22383258.v1
Autor:
Mien-Chie Hung, Gabriel N. Hortobagyi, Robert C. Bast, Jung-Mao Hsu, PoShen B. Chen, Michael Hsiao, Ying-Nai Wang, Kuo-Tai Hua, How-Wen Ko, Dung-Fang Lee, Chao-Feng Hou, Yi-Wen Chang, Hirohito Yamaguchi, Xiaoyun Cheng, Jen-Liang Su
Gene therapy trials in human breast, ovarian, and head and neck tumors indicate that adenovirus E1A can sensitize cancer cells to the cytotoxic effects of paclitaxel in vitro and in vivo. Resistance to paclitaxel has been reported to occur in cells e
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3a8c77b40df38e63bb8b4779af7e3f1d
https://doi.org/10.1158/0008-5472.c.6502763.v1
https://doi.org/10.1158/0008-5472.c.6502763.v1
Autor:
Mien-Chie Hung, Gabriel N. Hortobagyi, Robert C. Bast, Jung-Mao Hsu, PoShen B. Chen, Michael Hsiao, Ying-Nai Wang, Kuo-Tai Hua, How-Wen Ko, Dung-Fang Lee, Chao-Feng Hou, Yi-Wen Chang, Hirohito Yamaguchi, Xiaoyun Cheng, Jen-Liang Su
PDF file - 418K
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::673da944ffc52abfc369cfb3f92bba54
https://doi.org/10.1158/0008-5472.22389932.v1
https://doi.org/10.1158/0008-5472.22389932.v1
Autor:
Mien-Chie Hung, Gabriel N. Hortobagyi, Robert C. Bast, Jung-Mao Hsu, PoShen B. Chen, Michael Hsiao, Ying-Nai Wang, Kuo-Tai Hua, How-Wen Ko, Dung-Fang Lee, Chao-Feng Hou, Yi-Wen Chang, Hirohito Yamaguchi, Xiaoyun Cheng, Jen-Liang Su
PDF file - 162K
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1883d60f65e48cb4a0e6c8f667923e61
https://doi.org/10.1158/0008-5472.22389935
https://doi.org/10.1158/0008-5472.22389935
Autor:
Mien-Chie Hung, Michael Hsiao, Xiaoyun Cheng, Yi-Hua Jan, Yi-Wen Chang, Shang-Chih Chen, Ya-Huey Chen, Poshen B. Chen, Jen-Liang Su
Supplementary Table 1, Methods, Figure Legends 1-7 from Downregulation of MicroRNA miR-520h by E1A Contributes to Anticancer Activity
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::32b2b49b30157feaef950dcedbeba7e5
https://doi.org/10.1158/0008-5472.22383255
https://doi.org/10.1158/0008-5472.22383255
Autor:
Mien-Chie Hung, Michael Hsiao, Xiaoyun Cheng, Yi-Hua Jan, Yi-Wen Chang, Shang-Chih Chen, Ya-Huey Chen, Poshen B. Chen, Jen-Liang Su
The leading cause of death in cancer patients is cancer metastasis, for which there is no effective treatment. MicroRNAs (miRNA) have been shown to play a significant role in cancer metastasis through regulation of gene expression. The adenovirus typ
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ba9379193c5dcf64b6f40a567b102595
https://doi.org/10.1158/0008-5472.c.6500475
https://doi.org/10.1158/0008-5472.c.6500475
Autor:
Poshen B. Chen, Jiejun Wu, Pejman Soroosh, Bhuvan Molparia, German R. Aleman Muench, Luke J. Leman, Alan Saghatelian, Weixuan Chen, M. Reza Ghadiri, Audrey S. Black, Purba Mukherjee, Ali Torkamani, Nina E. Moore, Antonio Pinto, Adam L. Sobel, Bruce E. Maryanoff, Yannan Zhao
Publikováno v:
Nature biotechnology
The gut microbiome is a malleable microbial community that can remodel in response to various factors, including diet, and contribute to the development of several chronic diseases, including atherosclerosis. We devised an in vitro screening protocol
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::725b1b12d5c6263bc961861a641060bf
https://doi.org/10.1038/s41587-020-0549-5
https://doi.org/10.1038/s41587-020-0549-5
Autor:
Poshen B. Chen, Patrick C. Fiaux, Kai Zhang, Bin Li, Naoki Kubo, Shan Jiang, Rong Hu, Emma Rooholfada, Sihan Wu, Mengchi Wang, Wei Wang, Graham McVicker, Paul S. Mischel, Bing Ren
Publikováno v:
Cell reports, vol 41, iss 6
A scarcity of functionally validated enhancers in the human genome presents a significant hurdle to understanding how these cis-regulatory elements contribute to human diseases. We carry out highly multiplexed CRISPR-based perturbation and sequencing
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1c0dd13b64168d7f9e762f888b0e732d
https://pubmed.ncbi.nlm.nih.gov/36351387
https://pubmed.ncbi.nlm.nih.gov/36351387