Teriflunomide treatment for multiple sclerosis modulates T cell mitochondrial respiration with affinity-dependent effects.

Autor: Klotz L; University Hospital Münster, Department of Neurology with Institute of Translational Neurology, 48149 Münster, Germany. luisa.klotz@ukmuenster.de., Eschborn M; University Hospital Münster, Department of Neurology with Institute of Translational Neurology, 48149 Münster, Germany., Lindner M; University Hospital Münster, Department of Neurology with Institute of Translational Neurology, 48149 Münster, Germany., Liebmann M; University Hospital Münster, Department of Neurology with Institute of Translational Neurology, 48149 Münster, Germany., Herold M; University Hospital Münster, Department of Neurology with Institute of Translational Neurology, 48149 Münster, Germany., Janoschka C; University Hospital Münster, Department of Neurology with Institute of Translational Neurology, 48149 Münster, Germany., Torres Garrido B; University Hospital Münster, Department of Neurology with Institute of Translational Neurology, 48149 Münster, Germany., Schulte-Mecklenbeck A; University Hospital Münster, Department of Neurology with Institute of Translational Neurology, 48149 Münster, Germany., Gross CC; University Hospital Münster, Department of Neurology with Institute of Translational Neurology, 48149 Münster, Germany., Breuer J; University Hospital Münster, Department of Neurology with Institute of Translational Neurology, 48149 Münster, Germany., Hundehege P; University Hospital Münster, Department of Neurology with Institute of Translational Neurology, 48149 Münster, Germany., Posevitz V; University Hospital Münster, Department of Neurology with Institute of Translational Neurology, 48149 Münster, Germany., Pignolet B; CRC-SEP, Neurosciences Department, Toulouse University Hospital and INSERM U1043 - CNRS UMR 5282, Centre de Physiopathologie Toulouse-Purpan, Université Toulouse III, 31300 Toulouse, France., Nebel G; University of Münster, Institute of Molecular Cell Biology, 48149 Münster, Germany., Glander S; University of Münster, Department of Genetic Epidemiology, 48149 Münster, Germany., Freise N; University of Münster, Department of Immunology, 48149 Münster, Germany., Austermann J; University of Münster, Department of Immunology, 48149 Münster, Germany., Wirth T; University Hospital Münster, Department of Neurology with Institute of Translational Neurology, 48149 Münster, Germany., Campbell GR; University of Edinburgh, Centre for Clinical Brain Sciences, EH8 9YL Edinburgh, UK., Schneider-Hohendorf T; University Hospital Münster, Department of Neurology with Institute of Translational Neurology, 48149 Münster, Germany., Eveslage M; University of Münster, Institute of Biostatistics and Clinical Research, 48149 Münster, Germany., Brassat D; CRC-SEP, Neurosciences Department, Toulouse University Hospital and INSERM U1043 - CNRS UMR 5282, Centre de Physiopathologie Toulouse-Purpan, Université Toulouse III, 31300 Toulouse, France., Schwab N; University Hospital Münster, Department of Neurology with Institute of Translational Neurology, 48149 Münster, Germany., Loser K; University Hospital Münster, Department of Dermatology, 48149 Münster, Germany., Roth J; University of Münster, Department of Immunology, 48149 Münster, Germany., Busch KB; University of Münster, Institute of Molecular Cell Biology, 48149 Münster, Germany., Stoll M; University of Münster, Department of Genetic Epidemiology, 48149 Münster, Germany.; Department of Biochemistry, Cardiovascular Research Institute Maastricht, Maastricht University, 6229 ER Maastricht, Netherlands., Mahad DJ; University of Edinburgh, Centre for Clinical Brain Sciences, EH8 9YL Edinburgh, UK., Meuth SG; University Hospital Münster, Department of Neurology with Institute of Translational Neurology, 48149 Münster, Germany., Turner T; Sanofi Genzyme, Cambridge, MA 02142, USA., Bar-Or A; Center for Neuroinflammation and Experimental Therapeutics and Department of Neurology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA., Wiendl H; University Hospital Münster, Department of Neurology with Institute of Translational Neurology, 48149 Münster, Germany.; Brain and Mind Centre, Medical Faculty, University of Sydney, Sydney, Camperdown, NSW 2050, Australia.

Publikováno v: Science translational medicine [Sci Transl Med] 2019 May 01; Vol. 11 (490).

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B7-H1 Selectively Controls TH17 Differentiation and Central Nervous System Autoimmunity via a Novel Non-PD-1-Mediated Pathway.

Autor: Herold M; Department of Neurology, University of Muenster, 48149 Muenster, Germany;, Posevitz V; Department of Neurology, University of Muenster, 48149 Muenster, Germany;, Chudyka D; Department of Neurology, University of Muenster, 48149 Muenster, Germany;, Hucke S; Department of Neurology, University of Muenster, 48149 Muenster, Germany;, Groß C; Department of Neurology, University of Muenster, 48149 Muenster, Germany;, Kurth F; Department of Neurology, University of Muenster, 48149 Muenster, Germany;, Leder C; Experimental Cardiology, University of Tuebingen, 72076 Tuebingen, Germany;, Loser K; Department of Dermatology, University of Muenster, 48149 Muenster, Germany;, Kurts C; Institute of Experimental Immunology, University Clinic Bonn, 53127 Bonn, Germany; and., Knolle P; Institute of Molecular Immunology, Technical University Munich, 81675 Munich, Germany., Klotz L; Department of Neurology, University of Muenster, 48149 Muenster, Germany; heinz.wiendl@ukmuenster.de luisa.klotz@ukmuenster.de., Wiendl H; Department of Neurology, University of Muenster, 48149 Muenster, Germany; heinz.wiendl@ukmuenster.de luisa.klotz@ukmuenster.de.

Publikováno v: Journal of immunology (Baltimore, Md. : 1950) [J Immunol] 2015 Oct 15; Vol. 195 (8), pp. 3584-95. Date of Electronic Publication: 2015 Sep 16.

Coengineering specificity, safety, and function into T cells for cancer immunotherapy.

Autor: Giordano Attianese, Greta Maria Paola¹ (AUTHOR), Ash, Sarah¹ (AUTHOR), Irving, Melita¹ (AUTHOR) melita.irving@unil.ch

Publikováno v: Immunological Reviews. Nov2023, Vol. 320 Issue 1, p166-198. 33p.