Meta-analysis of genome-wide association studies identifies ancestry-specific associations underlying circulating total tau levels.

Autor: Sarnowski C; Department of Epidemiology, Human Genetics, and Environmental Sciences, University of Texas Health Science Center at Houston, Houston, TX, USA. Chloe.Sarnowski@uth.tmc.edu., Ghanbari M; Department of Epidemiology, Erasmus University Medical Center, Rotterdam, The Netherlands.; Department of Genetics, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran., Bis JC; Cardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, WA, USA., Logue M; National Center for PTSD, Behavioral Sciences Division, VA Boston Healthcare System, Boston, MA, USA.; Department of Psychiatry and Biomedical Genetics, Boston University School of Medicine, Boston, MA, USA., Fornage M; University of Texas Health Sciences Center at Houston, Houston, TX, USA., Mishra A; University of Bordeaux, Inserm, Bordeaux Population Health Research Center, team VINTAGE, UMR 1219, F-33000, Bordeaux, France., Ahmad S; Department of Epidemiology, Erasmus University Medical Center, Rotterdam, The Netherlands.; Division of Systems Biomedicine and Pharmacology, Leiden Academic Centre for Drug Research, Leiden University, Leiden, The Netherlands., Beiser AS; Department of Biostatistics, Boston University School of Public Health, Boston, MA, USA.; Boston University and the NHLBI's Framingham Heart Study, Boston, MA, USA.; Department of Neurology, Boston University School of Medicine, Boston, MA, USA., Boerwinkle E; University of Texas Health Sciences Center at Houston, Houston, TX, USA., Bouteloup V; Centre Inserm U1219 Bordeaux Population Health, CIC1401-EC, Institut de Santé Publique, d'Epidémiologie et de Développement, Université de Bordeaux, CHU de Bordeaux, Pôle Santé Publique, Bordeaux, France., Chouraki V; Univ. Lille, Inserm, CHU Lille, Institut Pasteur de Lille, U1167 - RID-AGE- LabEx DISTALZ - Risk factors and molecular determinants of aging diseases, F-59000, Lille, France., Cupples LA; Department of Biostatistics, Boston University School of Public Health, Boston, MA, USA.; Boston University and the NHLBI's Framingham Heart Study, Boston, MA, USA., Damotte V; Univ. Lille, Inserm, CHU Lille, Institut Pasteur de Lille, U1167 - RID-AGE- LabEx DISTALZ - Risk factors and molecular determinants of aging diseases, F-59000, Lille, France., DeCarli CS; Department of Neurology and Center for Neuroscience, University of California at Davis, Davis, CA, USA., DeStefano AL; Department of Biostatistics, Boston University School of Public Health, Boston, MA, USA., Djoussé L; Department of Medicine, Division of Aging, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA., Fohner AE; Institute of Public Health Genetics and Department of Epidemiology and Cardiovascular Health Research Unit, University of Washington, Seattle, WA, USA., Franz CE; Department of Psychiatry and Center for Behavior Genetics of Aging, University of California, San Diego, La Jolla, CA, USA., Kautz TF; Glenn Biggs Institute for Alzheimer's & Neurodegenerative Diseases, University of Texas Health Sciences Center, San Antonio, TX, USA., Lambert JC; Univ. Lille, Inserm, CHU Lille, Institut Pasteur de Lille, U1167 - RID-AGE- LabEx DISTALZ - Risk factors and molecular determinants of aging diseases, F-59000, Lille, France., Lyons MJ; Department of Psychology and Brain Sciences, Boston University, Boston, MA, USA., Mosley TH; University of Mississippi Medical Center, Jackson, MS, USA., Mukamal KJ; Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA., Pase MP; Turner Institute for Brain and Mental Health, Monash University, Melbourne, VIC, Australia.; Harvard T.H. Chan School of Public Health, Harvard University, Boston, MA, USA., Portilla Fernandez EC; Department of Epidemiology, Erasmus University Medical Center, Rotterdam, The Netherlands., Rissman RA; Department of Neurosciences, University of California, San Diego, La Jolla, CA, USA., Satizabal CL; Boston University and the NHLBI's Framingham Heart Study, Boston, MA, USA.; Department of Neurology, Boston University School of Medicine, Boston, MA, USA.; Glenn Biggs Institute for Alzheimer's & Neurodegenerative Diseases, University of Texas Health Sciences Center, San Antonio, TX, USA., Vasan RS; Boston University and the NHLBI's Framingham Heart Study, Boston, MA, USA.; Preventive Medicine & Epidemiology, Boston University School of Medicine, Boston, MA, USA., Yaqub A; Department of Epidemiology, Erasmus University Medical Center, Rotterdam, The Netherlands., Debette S; University of Bordeaux, Inserm, Bordeaux Population Health Research Center, team VINTAGE, UMR 1219, F-33000, Bordeaux, France.; Bordeaux University Hospital, Department of Neurology, Institute for Neurodegenerative Diseases, Bordeaux, France., Dufouil C; Bordeaux University Hospital, Department of Neurology, Institute for Neurodegenerative Diseases, Bordeaux, France., Launer LJ; National Institute on Aging, Baltimore, MD, USA., Kremen WS; Department of Psychiatry and Center for Behavior Genetics of Aging, University of California, San Diego, La Jolla, CA, USA., Longstreth WT; Departments of Neurology and Epidemiology, University of Washington, Seattle, WA, USA., Ikram MA; Department of Epidemiology, Erasmus University Medical Center, Rotterdam, The Netherlands., Seshadri S; Boston University and the NHLBI's Framingham Heart Study, Boston, MA, USA.; Department of Neurology, Boston University School of Medicine, Boston, MA, USA.; Glenn Biggs Institute for Alzheimer's & Neurodegenerative Diseases, University of Texas Health Sciences Center, San Antonio, TX, USA.

Publikováno v: Communications biology [Commun Biol] 2022 Apr 08; Vol. 5 (1), pp. 336. Date of Electronic Publication: 2022 Apr 08.