Zobrazeno 1 - 10
of 59
pro vyhledávání: '"Portia A Kreiger"'
Autor:
Catherine A Chapin, Sarah A Taylor, Padmini Malladi, Katie Neighbors, Hector Melin‐Aldana, Portia A Kreiger, Nina Bowsher, Matthew J Schipma, Kathleen M Loomes, Edward M Behrens, Estella M Alonso
Publikováno v:
Hepatology Communications, Vol 5, Iss 8, Pp 1373-1384 (2021)
Many patients with indeterminate pediatric acute liver failure (PALF) have evidence of T‐cell driven immune injury; however, the precise inflammatory pathways are not well defined. We have characterized the hepatic cytokine and transcriptional sign
Externí odkaz:
https://doaj.org/article/3907a2ec2a3144ef8b11941980ffb8a2
Autor:
Tamir Diamond, Thomas N Burn, Mailyn A Nishiguchi, Danielle Minichino, Julie Chase, Niansheng Chu, Portia A Kreiger, Edward M Behrens
Publikováno v:
PLoS ONE, Vol 17, Iss 6, p e0269553 (2022)
Interferon gamma (IFN-γ) is the main cytokine driving organ dysfunction in Familial Hemophagocytic Lymphohistiocytosis (FHL). Blockade of IFN-γ pathway ameliorates FHL hepatitis, both in animal models and in humans with FHL. Hepatocytes are known t
Externí odkaz:
https://doaj.org/article/0fcb53d025e74ae28392b294f706d544
Autor:
Gustavo Nino, Aihua Hu, Judith S Grunstein, Joseph McDonough, Portia A Kreiger, Maureen B Josephson, John K Choi, Michael M Grunstein
Publikováno v:
PLoS ONE, Vol 7, Iss 2, p e32078 (2012)
Since the Gβγ subunit of Gi protein has been importantly implicated in regulating immune and inflammatory responses, this study investigated the potential role and mechanism of action of Gβγ signaling in regulating the induction of airway hyperre
Externí odkaz:
https://doaj.org/article/de8aefe9780b474aa84d252b0771b0af
Autor:
Adam C. Resnick, Mariarita Santi, Zubair W Baloch, Minjie Luo, Rebecca L. Linn, Portia A. Kreiger, Fumin Lin, Stephen P. Hunger, Andrew J. Bauer, Marilyn M. Li, Pierre Russo, Elizabeth Fox, Chelsea Kotch, Phillip B. Storm, Jennifer Pogoriler, Vinodh Pillai, Lea F. Surrey, Xiaonan Zhao, Gerald Wertheim
Publikováno v:
JCO Precision Oncology
PURPOSE Neurotrophic tyrosine receptor kinase (NTRK) fusions have been described as oncogenic drivers in a variety of tumors. However, little is known about the overall frequency of NTRK fusion in unselected pediatric tumors. Here, we assessed the fr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4bf029cef86cc809bdaa7be746e98b8a
https://doi.org/10.1200/po.20.00250
https://doi.org/10.1200/po.20.00250
Autor:
Feng Xu, Angela N. Viaene, Jenny Ruiz, Jeffrey Schubert, Jinhua Wu, Jiani Chen, Kajia Cao, Weixuan Fu, Rochelle Bagatell, Zhiqian Fan, Ariel Long, Luca Pagliaroli, Yiming Zhong, Minjie Luo, Portia A. Kreiger, Lea F. Surrey, Gerald B. Wertheim, Kristina A. Cole, Marilyn M. Li, Mariarita Santi, Phillip B. Storm
Publikováno v:
Acta Neuropathologica Communications. 10
CIC-rearranged sarcomas are newly defined undifferentiated soft tissue tumors with CIC-associated fusions, and dismal prognosis. CIC fusions activate PEA3 family genes, ETV1/4/5, leading to tumorigenesis and progression. We report two high-grade CNS
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::31c983befd7957258f319940cecdd073
https://doi.org/10.1186/s40478-022-01401-z
https://doi.org/10.1186/s40478-022-01401-z
Autor:
Mikako Warren, Robyn C. Reed, Vinay Prasad, Veena Rajaram, Drucilla Roberts, Portia A. Kreiger, Lora Darrisaw, Sherri Besmer, Alanna J. Church, Matthew Keisling, Randall D. Craver, Bonnie L. Cole, James Robers, Dolores Lopez-Terrada
Publikováno v:
Pediatric and Developmental Pathology. :109352662311701
Background: Electron microscopy (EM), once an important component in diagnosing pediatric diseases, has experienced a decline in its use. To assess the impact of this, pediatric pathology practices were surveyed regarding EM services. Methods: The So
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d3049692cd7bf4a70607bca3b200cc06
https://doi.org/10.1177/10935266231170102
https://doi.org/10.1177/10935266231170102
Autor:
Alexander Nelson, D. Ashley Hill, Katie Gettinger, Douglas R. Stewart, Darren Klawinski, Kris Ann P. Schultz, Thomas A. Olson, Amanda Field, Portia A. Kreiger, Allison S Bechtel, Katrina Conard, Daniel V. Runco, Yoav H. Messinger, William A. Mize, Jason A. Jarzembowski, Andrew W. Walter, Mercedes Wilhelm, Anne K. Harris, Louis P. Dehner, Scott Bradfield, Mike Finch, Sarah Mitchell
Publikováno v:
Modern Pathology. 33:1922-1929
Since the original description of pathogenic germline DICER1 variation underlying pleuropulmonary blastoma (PPB), the spectrum of extrapulmonary neoplasms known to be associated with DICER1 has continued to expand and now includes tumors of the ovary
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::87345adc03f8b351e2d347a44ae727db
https://doi.org/10.1038/s41379-020-0558-4
https://doi.org/10.1038/s41379-020-0558-4
Autor:
Lorena A. Ostilla, Portia A. Kreiger, Mike A. Leonis, Sarah A. Taylor, Katie Neighbors, Catherine A Chapin, Robert H. Squires, Simon Horslen, Hector Melin-Aldana, Estella M. Alonso, Joshua B. Wechsler, Thomas Burn, Edward M. Behrens, Kathleen M. Loomes
Publikováno v:
Journal of Pediatric Gastroenterology & Nutrition. 71:713-719
Objectives In many pediatric acute liver failure (PALF) cases, a diagnosis is not identified, and the etiology is indeterminate (IND-PALF). Our pilot study found dense CD8 T-cell infiltrates and increased T-cell clonality in liver specimens from IND-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::518104f8f4c4ca34554d62789747f9e2
https://doi.org/10.1097/mpg.0000000000002893
https://doi.org/10.1097/mpg.0000000000002893
Autor:
N. Scott Adzick, Daniel T. Swarr, William H. Peranteau, Jennifer Pogoriler, Portia A. Kreiger
Publikováno v:
American Journal of Surgical Pathology. 43:47-55
Asymptomatic cystic lung lesions-congenital pulmonary airway malformations (CPAMs), sequestrations, and bronchogenic cysts-are commonly diagnosed prenatally. Indications to resect are to eliminate risk of malignancy or infection. CPAMs consist of a s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::920bdfc1f91494411c7fc5209e20a7df
https://doi.org/10.1097/pas.0000000000000992
https://doi.org/10.1097/pas.0000000000000992
Autor:
Scott M. Gordon, Charline Miot, Tamir Diamond, Craig H. Bassing, Erica Culberson, Ed Behrens, Thomas N. Burn, Katharina E. Hayer, Portia A. Kreiger, Anamika Bhattacharyya, Jessica M. Jones
RAG1/RAG2 (RAG) endonuclease-mediated assembly of diverse lymphocyte antigen receptor genes by V(D)J recombination is critical for the development and immune function of T and B cells. However, this process creates highly self-reactive cells that mus
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9668323ec2af95ae2d305e6d2b32ea26
https://doi.org/10.1101/2021.01.04.425211
https://doi.org/10.1101/2021.01.04.425211
