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Unfolded Von Willebrand Factor Interacts with Protein S and Limits Its Anticoagulant Activity

Autor: Sim, Martha MS, Alfar, Hammodah ^*, Hollifield, Melissa ^*, Chung, Dominic W., Fu, Xiaoyun, Banerjee, Meenakshi ^*, Peng, Chi, Li, Xian, Thornton, Alice ^*, Porterfield, James Z ^*, Sturgill, Jamie ^*, Sievert, Gail A ^*, Barton-Baxter, Marietta ^*, Campbell, Kenneth S ^*, Woodward, Jerold G ^*, López, José A., Whiteheart, Sidney W, Garvy, Beth A ^*, Wood, Jeremy P

Publikováno v: In Blood 15 November 2022 140 Supplement 1:2710-2711

Unfolded Von Willebrand Factor Binds Protein S and Reduces Anticoagulant Activity.

Autor: Sim MMS; Department of Molecular and Cellular Biochemistry, University of Kentucky, KY, USA., Mollica MY; Bloodworks Northwest Research Institute, WA, USA.; Division of Hematology, School of Medicine, University of Washington, WA, USA.; Department of Mechanical Engineering, University of Maryland, Baltimore County, MD, USA., Alfar HR; Department of Molecular and Cellular Biochemistry, University of Kentucky, KY, USA., Hollifield M; Department of Microbiology, Immunology and Molecular Genetics, University of Kentucky, KY, USA., Chung DW; Bloodworks Northwest Research Institute, WA, USA.; Department of Biochemistry, University of Washington, WA, USA., Fu X; Bloodworks Northwest Research Institute, WA, USA.; Division of Hematology, School of Medicine, University of Washington, WA, USA., Gandhapudi S; Department of Microbiology, Immunology and Molecular Genetics, University of Kentucky, KY, USA., Coenen DM; Department of Molecular and Cellular Biochemistry, University of Kentucky, KY, USA., Prakhya KS; Department of Molecular and Cellular Biochemistry, University of Kentucky, KY, USA., Mahmood DFD; Saha Cardiovascular Research Center, University of Kentucky, KY, USA., Banerjee M; Department of Molecular and Cellular Biochemistry, University of Kentucky, KY, USA., Peng C; Department of Pharmacology and Nutritional Sciences, University of Kentucky, KY, USA., Li X; Saha Cardiovascular Research Center, University of Kentucky, KY, USA., Thornton AC; Division of Infectious Disease, University of Kentucky, KY, USA., Porterfield JZ; Department of Microbiology, Immunology and Molecular Genetics, University of Kentucky, KY, USA.; Division of Infectious Disease, University of Kentucky, KY, USA., Sturgill JL; Department of Microbiology, Immunology and Molecular Genetics, University of Kentucky, KY, USA., Sievert GA; Center for Clinical and Translational Science, University of Kentucky, KY, USA., Barton-Baxter M; Center for Clinical and Translational Science, University of Kentucky, KY, USA., Zheng Z; Department of Medicine, Medical College of Wisconsin, Milwaukee, WI, USA.; Versiti Blood Research Institute, Milwaukee, WI, USA., Campbell KS; Center for Clinical and Translational Science, University of Kentucky, KY, USA., Woodward JG; Department of Microbiology, Immunology and Molecular Genetics, University of Kentucky, KY, USA., López JA; Bloodworks Northwest Research Institute, WA, USA.; Division of Hematology, School of Medicine, University of Washington, WA, USA., Whiteheart SW; Department of Molecular and Cellular Biochemistry, University of Kentucky, KY, USA.; Saha Cardiovascular Research Center, University of Kentucky, KY, USA., Garvy BA; Department of Microbiology, Immunology and Molecular Genetics, University of Kentucky, KY, USA., Wood JP; Department of Molecular and Cellular Biochemistry, University of Kentucky, KY, USA.; Saha Cardiovascular Research Center, University of Kentucky, KY, USA.; Division of Cardiovascular Medicine Gill Heart and Vascular Institute, University of Kentucky, KY, USA.

Publikováno v: BioRxiv : the preprint server for biology [bioRxiv] 2024 Feb 09. Date of Electronic Publication: 2024 Feb 09.