Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Porsha R. Howell"'
Autor:
Inca A. Dieterich, Alexis J. Lawton, Yajing Peng, Qing Yu, Timothy W. Rhoads, Katherine A. Overmyer, Yusi Cui, Eric A. Armstrong, Porsha R. Howell, Maggie S. Burhans, Lingjun Li, John M. Denu, Joshua J. Coon, Rozalyn M. Anderson, Luigi Puglielli
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-11 (2019)
The Endoplasmic Reticulum acetylation machinery ensures proper quality control and disposal of newly folded proteins transiting the secretory pathway. Here, the authors show that this machinery acts as a metabolic regulator of acetyl-CoA homeostasis,
Externí odkaz:
https://doaj.org/article/0d4577b03c594bb194303bbedd2c9a54
Publikováno v:
EBioMedicine, Vol 21, Iss C, Pp 37-44 (2017)
Aging as a research pursuit is fairly new compared with traditional lines of medical research. A growing field of investigators is focused on understanding how changes in tissue biology, physiology, and systemic homeostasis, conspire to create increa
Externí odkaz:
https://doaj.org/article/2b3c2700336a420d868c9730664579df
Autor:
Priya Balasubramanian, Anne E Schaar, Grace E Gustafson, Alex B Smith, Porsha R Howell, Angela Greenman, Scott Baum, Ricki J Colman, Dudley W Lamming, Gary M Diffee, Rozalyn M Anderson
Publikováno v:
eLife, Vol 11 (2022)
The loss of skeletal muscle function with age, known as sarcopenia, significantly reduces independence and quality of life and can have significant metabolic consequences. Although exercise is effective in treating sarcopenia it is not always a viabl
Externí odkaz:
https://doaj.org/article/70070234940c48fc8d99e9a3f893e406
Autor:
Anne E Schaar, Priya Balasubramanian, Grace E Gustafson, Alex B Smith, Porsha R Howell, Angela Greenman, Scott Baum, Ricki J Colman, Dudley W Lamming, Gary M Diffee, Rozalyn M Anderson
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2fbeeecbde4d225780a916ad5b7254db
https://doi.org/10.7554/elife.71282.sa2
https://doi.org/10.7554/elife.71282.sa2
Autor:
Sehgal R, Perez-Matos Mc, William B. Mair, Hannah J. Smith, Mutlu As, Meeta Mistry, Porsha R. Howell, Anne Lanjuin, Sneha Dutta, Meng C. Wang, Arpit Sharma, Mary E. Piper, Caroline Heintz
Geroscience aims to target the aging process to extend healthspan. However, even isogenic individuals show heterogeneity in natural aging rate and responsiveness to pro-longevity interventions, limiting translational potential. Using in vivo mini gen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8b91c2b30e545cde54ca5814f2ebef4f
https://doi.org/10.1101/2021.11.01.466772
https://doi.org/10.1101/2021.11.01.466772
Autor:
Luigi Puglielli, John M. Denu, Yusi Cui, Porsha R. Howell, Qing Yu, Katherine A. Overmyer, Yajing Peng, Lingjun Li, Rozalyn M. Anderson, Alexis J. Lawton, Maggie S. Burhans, Inca A. Dieterich, Eric A. Armstrong, Timothy W. Rhoads, Joshua J. Coon
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-11 (2019)
Nature Communications
Nature Communications
AT-1/SLC33A1 is a key member of the endoplasmic reticulum (ER) acetylation machinery, transporting acetyl-CoA from the cytosol into the ER lumen where acetyl-CoA serves as the acetyl-group donor for Nε-lysine acetylation. Dysfunctional ER acetylatio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cd890c8b7ac5d183484e55a9e4282bad
http://link.springer.com/article/10.1038/s41467-019-11945-9
http://link.springer.com/article/10.1038/s41467-019-11945-9
Autor:
Karl N. Miller, Tyler M. DeMuth, Mary J. Lindstrom, Michael A. Polewski, Kevin W. Eliceiri, Josef P. Clark, James M. Ntambi, Porsha R. Howell, Rozalyn M. Anderson, Maggie S. Burhans
Publikováno v:
Aging Cell
Summary Adipose tissue expansion has been associated with system-wide metabolic dysfunction and increased vulnerability to diabetes, cancer, and cardiovascular disease. A reduction in adiposity is a hallmark of caloric restriction (CR), an interventi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e008b25892687bb881d92b0a41d323d3
https://doi.org/10.1111/acel.12575
https://doi.org/10.1111/acel.12575
Autor:
James M. Ntambi, Karl N. Miller, John M. Denu, Porsha R. Howell, Stephen A. Martin, Derek M. Pavelec, Rozalyn M. Anderson, Josef P. Clark, Avtar Roopra, Kevin W. Eliceiri, Maggie S. Burhans, Timothy W. Rhoads, Spencer A. Haws, Brian W. Parks, Nathan B. Johnson
Publikováno v:
Aging Cell
Deleterious changes in energy metabolism have been linked to aging and disease vulnerability, while activation of mitochondrial pathways has been linked to delayed aging by caloric restriction (CR). The basis for these associations is poorly understo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::37e7677d1e59097a7b0b2c38fd8e044f
https://doi.org/10.1111/acel.12999
https://doi.org/10.1111/acel.12999
Autor:
Bj K. Bryant, Jeffrey B. Arterburn, Samuel Kadavakollu, Chinnasamy Ramesh, Jon M. George, Rebecca Hirsch, Charles B. Shuster, Dennis L. Johnson, Porsha R. Howell, David Alexander, Lori Jo Wilmeth, Johnelle Montoya, Delany Rodriguez, Lauren H. Henson
Publikováno v:
Bioorganicmedicinal chemistry. 19(18)
Assembly of a bipolar mitotic spindle requires the action of class 5 kinesins, and inhibition or depletion of this motor results in mitotic arrest and apoptosis. S-Trityl-l-cysteine is an allosteric inhibitor of vertebrate Kinesin Spindle Protein (KS
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5d23ef059f19f861b13667581e538da4
https://pubmed.ncbi.nlm.nih.gov/21855351
https://pubmed.ncbi.nlm.nih.gov/21855351