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Genetically Modified Porcine Kidneys Have Sufficient Tissue Integrity for Use in Pig-to-Human Xenotransplantation.

Autor: Anderson DJ; Comprehensive Transplant Institute, University of Alabama at Birmingham, Birmingham, AL.; Department of Surgery, Division of Transplantation, Heersink School of Medicine, University of Alabama at Birmingham, Birmingham, AL., Jones-Carr M; Comprehensive Transplant Institute, University of Alabama at Birmingham, Birmingham, AL.; Department of Surgery, Division of Transplantation, Heersink School of Medicine, University of Alabama at Birmingham, Birmingham, AL., Perry J; Comprehensive Transplant Institute, University of Alabama at Birmingham, Birmingham, AL.; Department of Surgery, Division of Transplantation, Heersink School of Medicine, University of Alabama at Birmingham, Birmingham, AL., Kumar V; Comprehensive Transplant Institute, University of Alabama at Birmingham, Birmingham, AL.; Department of Medicine, Division of Nephrology, Heersink School of Medicine, University of Alabama at Birmingham, Birmingham, AL., Porrett PM; Comprehensive Transplant Institute, University of Alabama at Birmingham, Birmingham, AL.; Department of Surgery, Division of Transplantation, Heersink School of Medicine, University of Alabama at Birmingham, Birmingham, AL., Locke JE; Comprehensive Transplant Institute, University of Alabama at Birmingham, Birmingham, AL.; Department of Surgery, Division of Transplantation, Heersink School of Medicine, University of Alabama at Birmingham, Birmingham, AL.

Publikováno v: Annals of surgery [Ann Surg] 2024 Sep 01; Vol. 280 (3), pp. 374-382. Date of Electronic Publication: 2024 Jun 06.

HLA topography enforces shared and convergent immunodominant B cell and antibody alloresponses in transplant recipients.

Autor: Killian JT, Glenn King R, Lucander ACK, Kizziah JL, Fucile CF, Diaz-Avalos R, Qiu S, Silva-Sanchez A, Mousseau BJ, Macon KJ, Callahan AR, Yang G, Emon Hossain M, Akther J, Good DB, Kelso S, Houp JA, Rosenblum F, Porrett PM, Ong SC, Kumar V, Saphire EO, Kearney JF, Randall TD, Rosenberg AF, Green TJ, Lund FE

Publikováno v: BioRxiv : the preprint server for biology [bioRxiv] 2024 Jul 24. Date of Electronic Publication: 2024 Jul 24.

Spatiotemporal immune atlas of a clinical-grade gene-edited pig-to-human kidney xenotransplant.

Autor: Cheung MD; Department of Surgery, University of Alabama at Birmingham, Birmingham, AL, USA., Asiimwe R; Department of Surgery, University of Alabama at Birmingham, Birmingham, AL, USA., Erman EN; Department of Surgery, University of Alabama at Birmingham, Birmingham, AL, USA., Fucile CF; Informatics Institute, University of Alabama at Birmingham, Birmingham, AL, USA., Liu S; Department of Biochemistry and Molecular Genetics, University of Alabama at Birmingham, Birmingham, AL, USA.; Flow Cytometry & Single Cell Core Facility, University of Alabama at Birmingham, Birmingham, AL, USA., Sun CW; Department of Biochemistry and Molecular Genetics, University of Alabama at Birmingham, Birmingham, AL, USA.; Flow Cytometry & Single Cell Core Facility, University of Alabama at Birmingham, Birmingham, AL, USA., Hanumanthu VS; Flow Cytometry & Single Cell Core Facility, University of Alabama at Birmingham, Birmingham, AL, USA., Pal HC; Flow Cytometry & Single Cell Core Facility, University of Alabama at Birmingham, Birmingham, AL, USA., Wright ED; Department of Surgery, University of Alabama at Birmingham, Birmingham, AL, USA., Ghajar-Rahimi G; Department of Surgery, University of Alabama at Birmingham, Birmingham, AL, USA., Epstein D; Department of Surgery, University of Alabama at Birmingham, Birmingham, AL, USA., Orandi BJ; Department of Surgery, University of Alabama at Birmingham, Birmingham, AL, USA., Kumar V; Department of Medicine, University of Alabama at Birmingham, Birmingham, AL, USA., Anderson DJ; Department of Surgery, University of Alabama at Birmingham, Birmingham, AL, USA., Greene ME; Department of Surgery, University of Alabama at Birmingham, Birmingham, AL, USA., Bell M; Department of Surgery, University of Alabama at Birmingham, Birmingham, AL, USA., Yates S; Department of Surgery, University of Alabama at Birmingham, Birmingham, AL, USA., Moore KH; Department of Medicine, University of Alabama at Birmingham, Birmingham, AL, USA., LaFontaine J; Department of Surgery, University of Alabama at Birmingham, Birmingham, AL, USA., Killian JT Jr; Department of Surgery, University of Alabama at Birmingham, Birmingham, AL, USA., Baker G; Department of Surgery, University of Alabama at Birmingham, Birmingham, AL, USA., Perry J; Department of Surgery, University of Alabama at Birmingham, Birmingham, AL, USA., Khan Z; Department of Surgery, University of Alabama at Birmingham, Birmingham, AL, USA., Reed R; Department of Surgery, University of Alabama at Birmingham, Birmingham, AL, USA., Little SC; Department of Surgery, University of Alabama at Birmingham, Birmingham, AL, USA., Rosenberg AF; Informatics Institute, University of Alabama at Birmingham, Birmingham, AL, USA.; Department of Microbiology, University of Alabama at Birmingham, Birmingham, AL, USA., George JF; Department of Surgery, University of Alabama at Birmingham, Birmingham, AL, USA., Locke JE; Department of Surgery, University of Alabama at Birmingham, Birmingham, AL, USA., Porrett PM; Department of Surgery, University of Alabama at Birmingham, Birmingham, AL, USA. pmporrett@uabmc.edu.

Publikováno v: Nature communications [Nat Commun] 2024 Apr 11; Vol. 15 (1), pp. 3140. Date of Electronic Publication: 2024 Apr 11.