Zobrazeno 1 - 10
of 26
pro vyhledávání: '"Pornwaratt, Niyomrattanakit"'
Autor:
Ujjini H. Manjunatha, Cynthia S. Dowd, Helena I. Boshoff, Jo Ann Tay, Amit Nayyar, Pornwaratt Niyomrattanakit, Yong Sok Lee, Clifton E. Barry, Tathagata Mukherjee, Meera Gurumurthy, Ramandeep Singh, Thomas Dick, Joseph Cherian
Publikováno v:
FEBS Journal. 279:113-125
The bicyclic 4-nitroimidazoles PA-824 and OPC-67683 represent a promising novel class of therapeutics for tuberculosis (TB) and are currently in phase II clinical development. Both compounds are pro-drugs that are reductively activated by a deazaflav
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2def10bb9ca6854b1bd8d5b72eaba72e
https://doi.org/10.1111/j.1742-4658.2011.08404.x
https://doi.org/10.1111/j.1742-4658.2011.08404.x
Autor:
Yong Sok Lee, Clifton E. Barry, Young Hwan Ha, Jan Jiricek, Thomas H. Keller, Pornwaratt Niyomrattanakit, Sindhu Ravindran, Thomas Dick, Michael Goodwin, Véronique Dartois, Tathagata Mukherjee, Suresh B. Lakshminarayana, Ujjini H. Manjunatha, Helena I. Boshoff, Joseph Cherian, Inhee Choi, Ramandeep Singh, Amit Nayyar
Publikováno v:
Journal of Medicinal Chemistry. 54:5639-5659
The (S)-2-nitro-6-(4-(trifluoromethoxy)benzyloxy)-6,7-dihydro-5H-imidazo[2,1-b][1,3]oxazine named PA-824 (1) has demonstrated antitubercular activity in vitro and in animal models and is currently in clinical trials. We synthesized derivatives at thr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::99931f461d7a119cb7d418b72de9bac0
https://doi.org/10.1021/jm1010644
https://doi.org/10.1021/jm1010644
Autor:
Dieter Mueller, Pornwaratt Niyomrattanakit, J. Frasier Glickman, Hongping Dong, Min Qing, Zheng Yin, Thomas H. Keller, Hans Voshol, Kai Lin, Joanne Y.H. Lim, Shahul Nilar, Pei Yong Shi, Yen Liang Chen
Publikováno v:
Journal of Virology. 84:5678-5686
Dengue virus (DENV) is the most prevalent mosquito-borne viral pathogen in humans. Neither vaccine nor antiviral therapy is currently available for DENV. We report here that N -sulfonylanthranilic acid derivatives are allosteric inhibitors of DENV RN
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f35a87282c18b8224c152f1b84312701
https://doi.org/10.1128/jvi.02451-09
https://doi.org/10.1128/jvi.02451-09
Autor:
Wai Ling Chan, Bo Zhang, Thomas H. Keller, Wouter Schul, Min Qing, Pei Yong Shi, Andy Yip, Kristen A. Bernard, Gang Zou, Hao Ying Xu, Suresh B. Lakshminarayana, Gang Wang, Anne Goh, Wei Liu, Min Dong, Boping Liu, Hui Pen Tan, Handan He, Qing Yin Wang, Margaret Weaver, Feng Gu, Yen Liang Chen, Zheng Yin, Pornwaratt Niyomrattanakit, Chuan Young Ng, Arkadius Pichota, Christine E. Garrett, Véronique Dartois, Joanne Y.H. Lim, Ravinder Reddy Kondreddi, Jeyaraj Duraiswamy, Kai Lin, Chin Chin Lim, Karen Beltz
Publikováno v:
Proceedings of the National Academy of Sciences. 106:20435-20439
Dengue virus (DENV), a mosquito-borne flavivirus, is a major public health threat. The virus poses risk to 2.5 billion people worldwide and causes 50 to 100 million human infections each year. Neither a vaccine nor an antiviral therapy is currently a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a316c5d40ed9639ddcd32990e5f5a43e
https://doi.org/10.1073/pnas.0907010106
https://doi.org/10.1073/pnas.0907010106
Autor:
Wai Ling Chan, Shahul Nilar, Subhash G. Vasudevan, Wan Yen Lee, Sigmar Dressler, Gang Wang, Pei Yong Shi, Alex Chao, Ru Hui Ng, Hans Voshol, Thomas H. Keller, Daying Wen, Yen Liang Chen, J. Fraser Glickman, Joanne Y.H. Lim, Pornwaratt Niyomrattanakit, Zheng Yin, Ravinder Reddy Kondreddi, Duraiswamy Athisayamani Jeyaraj, Carsten Spanka, Dieter Mueller
Publikováno v:
Journal of Medicinal Chemistry. 52:7934-7937
A novel class of compounds containing N-sulfonylanthranilic acid was found to specifically inhibit dengue viral polymerase. The structural requirements for inhibition and a preliminary structure-activity relationship are described. A UV cross-linking
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1534d73bf76116a17290459e8861aca0
https://doi.org/10.1021/jm901044z
https://doi.org/10.1021/jm901044z
Publikováno v:
FEMS Microbiology Letters. 287:128-135
Dihydropteroate synthase (DHPS) is involved in de novo biosynthesis of the essential cofactor folate by catalyzing the condensation of para-aminobenzoic acid (pABA) and 6-hydroxymethyl-7,8-dihydropterin-pyrophosphate (H2PtPP). Mycobacterium tuberculo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::77b7101c236f932408d2a700a088f8df
https://doi.org/10.1111/j.1574-6968.2008.01302.x
https://doi.org/10.1111/j.1574-6968.2008.01302.x
Autor:
Ka Yan Chung, Pei Yong Shi, Hongping Dong, Pornwaratt Niyomrattanakit, David Beer, Siti Nurdiana Abas, Cheah Chen Seh, Kah Fei Wan, Chang Bok Lee, Siew Pheng Lim, Julien Lescar, Shahul Nilar, Chin Chin Lim, Alex Chao
Publikováno v:
Antiviral research. 119
Dengue virus (DENV) NS5 protein comprises an N-terminal methyltransferase domain and a C-terminal RNA-dependent RNA polymerase domain (RdRp). DENV RdRp is responsible for viral RNA synthesis via a de novo initiation mechanism and represents an attrac
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9209cdfa37cfd4c2099dcc30ed003190
https://pubmed.ncbi.nlm.nih.gov/25896272
https://pubmed.ncbi.nlm.nih.gov/25896272
Autor:
Peteris Prusis, Pornwaratt Niyomrattanakit, Jarl E. S. Wikberg, Gerd Katzenmeier, Ilze Mutule, Sviatlana Yahorava, Felikss Mutulis, Ramona Petrovska
Publikováno v:
Biochemical Journal. 397:203-211
The NS3 (dengue virus non-structural protein 3) serine protease of dengue virus is an essential component for virus maturation, thus representing an attractive target for the development of antiviral drugs directed at the inhibition of polyprotein pr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c1ab2c1b69745dffdd6748d1c6e30fe8
https://doi.org/10.1042/bj20051767
https://doi.org/10.1042/bj20051767
Autor:
Supa Hannongbua, Pornwaratt Niyomrattanakit, Chak Sangma, Santad Chanprapaph, Gerd Katzenmeier, Chanan Angsuthanasombat, Patchreenart Saparpakorn
Publikováno v:
Biochemical and Biophysical Research Communications. 330:1237-1246
The NS3 serine protease of dengue virus is required for the maturation of the viral polyprotein and consequently represents a promising target for the development of antiviral inhibitors. However, the substrate specificity of this enzyme has been cha
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2e3bf8934b79e5fb16c6c842cfcb195b
https://doi.org/10.1016/j.bbrc.2005.03.107
https://doi.org/10.1016/j.bbrc.2005.03.107
Autor:
Philipp Krastel, Srinivasa P. S. Rao, Douglas Jeffery, Luis R. Camacho, Christian Zwingelstein, Pornwaratt Niyomrattanakit, Jun Zheng, Kevin Pethe, Christian G. Noble, Vivian Lim, Silvio Roggo, Melvin Au, David Beer, Vasan K. Sambandamurthy, Esther K. Schmitt, Meliana Riwanto, Charlotte Miault
Publikováno v:
Angewandte Chemie. 123:6011-6013
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::35c5270e01c0de9bd72a2694f8984e1d
https://doi.org/10.1002/ange.201101740
https://doi.org/10.1002/ange.201101740