Zobrazeno 1 - 10
of 21
pro vyhledávání: '"Pornpen, Labthavikul"'
Autor:
Pornpen Labthavikul, William Hu, Shaughnessy M. Naughton, Youjun Yang, David Keeney, Beth A. Rasmussen, Craig E. Caufield, Koi Michele Morris, Peter Petersen, Guy Singh, Schuyler Adam Antane
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 16:176-180
Pulvinones were synthesized (>180) in arrays and evaluated as inhibitors of early stage cell wall biosynthesis enzymes MurA-MurD. Several pulvinones inhibited Mur enzymes with IC(50)'s in the 1-10 microg/mL range and demonstrated antibacterial activi
Autor:
Lee D, Jennings, Kenneth W, Foreman, Thomas S, Rush, Desiree H H, Tsao, Lidia, Mosyak, Scott L, Kincaid, Mohani N, Sukhdeo, Alan G, Sutherland, Weidong, Ding, Cynthia Hess, Kenny, Chantel L, Sabus, Hanlan, Liu, Elizabeth G, Dushin, Soraya L, Moghazeh, Pornpen, Labthavikul, Peter J, Petersen, Margareta, Tuckman, Steven A, Haney, Alexey V, Ruzin
Publikováno v:
Bioorganic & Medicinal Chemistry. 12:5115-5131
The ZipA–FtsZ protein–protein interaction is a potential target for antibacterial therapy. The design and parallel synthesis of a combinatorial library of small molecules, which target the FtsZ binding area on ZipA are described. Compounds were d
Autor:
Nancy H. Eudy, Yang-I Lin, Pornpen Labthavikul, Zhong Li, Peter Petersen, Guy Singh, Gerardo D. Francisco, Youjun Yang, Tarek S. Mansour, J.Donald Albright, Beth A. Rasmussen, Alan H. Katz
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 14:235-238
Over 50 phenyl thiazolyl urea and carbamate derivatives were synthesized for evaluation as new inhibitors of bacterial cell-wall biosynthesis. Many of them demonstrated good activity against MurA and MurB and gram-positive bacteria including MRSA, VR
Autor:
Pornpen Labthavikul, Peter Petersen, Tarek S. Mansour, Guy Singh, Beth A. Rasmussen, Jerauld S. Skotnicki, Gerardo D. Francisco, William Hu, Youjun Yang, Yang-I Lin, Zhong Li, Anatoly Severin
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 13:2591-2594
Twenty-five 2-phenyl-5,6-dihydro-2H-thieno[3,2-c]pyrazol-3-ol derivatives were synthesized for evaluation as new inhibitors of bacterial cell wall biosynthesis. Many of them demonstrated good inhibitory activity against Staphylococcus aureus MurB, Mu
Autor:
B. Feld, David M. Rothstein, L. McDonald, Russell Dushin, William Hu, Margareta Tuckman, Peter Petersen, M. McGlynn, Steven J. Projan, M. P. Singh, Pornpen Labthavikul, Patricia A. Bradford, P. Burgio, L. E. Alksne, L. Barbieri
Publikováno v:
Antimicrobial Agents and Chemotherapy. 44:1418-1427
Protein secretion is an essential process for bacterial growth, yet there are few if any antimicrobial agents which inhibit secretion. An in vivo, high-throughput screen to detect secretion inhibitors was developed based on the translational autoregu
Autor:
Karen L. Wheless, Desiree H.H. Tsao, Weidong Ding, Juan C. Alvarez, Alexey Ruzin, Kenneth Foreman, Alan G. Sutherland, Pornpen Labthavikul, Lidia Mosyak, Thomas S. Rush, Peter Petersen, Cynthia Hess Kenny
Publikováno v:
Org. Biomol. Chem.. 1:4138-4140
Structural features of two weak inhibitors of the ZipA-FtsZ protein-protein interaction which were found to bind to overlapping but different areas of the key binding site were combined in one new series of carboxybiphenyl-indoles with improved inhib
Autor:
Steven A. Haney, Soraya L. Moghazeh, Thomas S. Rush, Pornpen Labthavikul, Margareta Tuckman, Peter Petersen, Lidia Mosyak, Lee D. Jennings, Mohani N. Sukhdeo, Weidong Ding, Alexey Ruzin, Hanlan Liu, Desiree H.H. Tsao, Scott L. Kincaid, Alan G. Sutherland, Cynthia Hess Kenny, Elizabeth G. Dushin, Chantel L. Sabus, Kenneth Foreman
Publikováno v:
Bioorganic & Medicinal Chemistry. 13:5884
Autor:
David C. Brittain, M. Juliana McElrath, Harold C. Neu, Brian E. Scully, Pornpen Labthavikul, Richard C. Steinman
Publikováno v:
The Journal of Clinical Pharmacology. 25:82-88
Ciprofloxacin is an investigational quinolone agent possessing an impressive antibacterial spectrum. Its pharmacokinetics were studied in six volunteers after 250-mg and 500-mg single oral doses, and its bactericidal activity compared to that of trim
Autor:
Pornpen Labthavikul, Harold C. Neu
Publikováno v:
Journal of Antimicrobial Chemotherapy. 9:49-57
Autor:
Harold C. Neu, Pornpen Labthavikul
Publikováno v:
Journal of Antimicrobial Chemotherapy. 9:101-106