Angiogenesis in Pediatric Malignancies - From Molecular Markers to Therapeutic Applications

Autor: Porkholm, Mikaela

Although most children with cancer can be cured, every fifth patient still succumb from their disease. The need for new treatments and more refined diagnostic methods are thus understandable. Angiogenesis, the formation of new blood vessels, is an es

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od______1593::d92f01cd077976561f28f18daa5cbbda
http://hdl.handle.net/10138/172340

Radiation therapy and concurrent topotecan followed by maintenance triple anti-angiogenic therapy with thalidomide, etoposide, and celecoxib for pediatric diffuse intrinsic pontine glioma

Autor: Porkholm, Mikaela, Valanne, Leena, Lönnqvist, Tuula, Holm, Stefan, Lannering, Birgitta, Riikonen, Pekka, Wojcik, Dorota, Sehested, Astrid, Clausen, Niels, Harila-Saari, Arja, Schomerus, Eckhard, Thorarinsdottir, Halldora K, Lähteenmäki, Päivi, Arola, Mikko, Thomassen, Harald, Saarinen-Pihkala, Ulla M, Kivivuori, Sanna-Maria

Publikováno v: Porkholm, M, Valanne, L, Lönnqvist, T, Holm, S, Lannering, B, Riikonen, P, Wojcik, D, Sehested, A, Clausen, N, Harila-Saari, A, Schomerus, E, Thorarinsdottir, H K, Lähteenmäki, P, Arola, M, Thomassen, H, Saarinen-Pihkala, U M & Kivivuori, S-M 2014, ' Radiation therapy and concurrent topotecan followed by maintenance triple anti-angiogenic therapy with thalidomide, etoposide, and celecoxib for pediatric diffuse intrinsic pontine glioma ', Pediatric Blood & Cancer, vol. 61, no. 9, pp. 1603-9 . https://doi.org/10.1002/pbc.25045

BACKGROUND: Despite major treatment attempts, the prognosis for pediatric diffuse intrinsic pontine gliomas (DIPGs) remains dismal. Gliomas are highly vascularized tumors, suggesting that the prevention of vessel formation by anti-angiogenic treatmen

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pure_au_____::acf120f521a2efe0d604522a21d74191
https://pure.au.dk/portal/da/publications/radiation-therapy-and-concurrent-topotecan-followed-by-maintenance-triple-antiangiogenic-therapy-with-thalidomide-etoposide-and-celecoxib-for-pediatric-diffuse-intrinsic-pontine-glioma(1de7f171-fcc7-4d9f-8a1c-e062eab70e1a).html

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