A breast cancer patient-derived xenograft and organoid platform for drug discovery and precision oncology

Autor: Ward Jh, Randy L. Jensen, Ling Zhao, Greenland Ja, Maihi Fujita, Rosenthal R, Saundra S. Buys, Anna C. Beck, Guoying Wang, Wadsworth Me, Emilio Cortes-Sanchez, Sandra D. Scherer, Chieh-Hsiang Yang, Katrin P. Guillen, Jeffrey H. Chuang, Cindy B. Matsen, Zheqi Li, Kristopher Berrett, Jeffery M. Vahrenkamp, David H. Lum, Alana L. Welm, Michael T. Lewis, Toner J, Jason Gertz, Chu Z, Poretta Jm, Yoko S. DeRose, Lacey E. Dobrolecki, Gabor T. Marth, Katherine E. Varley, Rachel E. Factor, Andrew Butterfield, Bryan E. Welm, Xiaomeng Huang, Edward W. Nelson, Matthew H. Bailey, Pathi Ss, Xing Yi Woo, Yi Qiao, Christos Vaklavas, Steffi Oesterreich, Kevin B. Jones

Model systems that recapitulate the complexity of human tumors and the reality of variable treatment responses are urgently needed to better understand cancer biology and to develop more effective cancer therapies. Here we report development and char

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::eb9f2dc64567b20d35abfdfca6812bd3
https://doi.org/10.1101/2021.02.28.433268

A human breast cancer-derived xenograft and organoid platform for drug discovery and precision oncology.

Autor: Guillen KP; Department of Oncological Sciences, University of Utah, Salt Lake City, UT, USA.; Huntsman Cancer Institute, University of Utah, Salt Lake City, UT, USA., Fujita M; Department of Oncological Sciences, University of Utah, Salt Lake City, UT, USA.; Huntsman Cancer Institute, University of Utah, Salt Lake City, UT, USA., Butterfield AJ; Department of Oncological Sciences, University of Utah, Salt Lake City, UT, USA.; Huntsman Cancer Institute, University of Utah, Salt Lake City, UT, USA., Scherer SD; Department of Oncological Sciences, University of Utah, Salt Lake City, UT, USA.; Huntsman Cancer Institute, University of Utah, Salt Lake City, UT, USA., Bailey MH; Huntsman Cancer Institute, University of Utah, Salt Lake City, UT, USA.; Eccles Institute of Human Genetics, University of Utah, Salt Lake City, UT, USA., Chu Z; Department of Oncological Sciences, University of Utah, Salt Lake City, UT, USA.; Huntsman Cancer Institute, University of Utah, Salt Lake City, UT, USA., DeRose YS; Department of Oncological Sciences, University of Utah, Salt Lake City, UT, USA.; Huntsman Cancer Institute, University of Utah, Salt Lake City, UT, USA., Zhao L; Department of Oncological Sciences, University of Utah, Salt Lake City, UT, USA.; Huntsman Cancer Institute, University of Utah, Salt Lake City, UT, USA., Cortes-Sanchez E; Department of Oncological Sciences, University of Utah, Salt Lake City, UT, USA.; Huntsman Cancer Institute, University of Utah, Salt Lake City, UT, USA., Yang CH; Department of Oncological Sciences, University of Utah, Salt Lake City, UT, USA.; Huntsman Cancer Institute, University of Utah, Salt Lake City, UT, USA., Toner J; Department of Oncological Sciences, University of Utah, Salt Lake City, UT, USA.; Huntsman Cancer Institute, University of Utah, Salt Lake City, UT, USA., Wang G; Department of Oncological Sciences, University of Utah, Salt Lake City, UT, USA.; Huntsman Cancer Institute, University of Utah, Salt Lake City, UT, USA., Qiao Y; Eccles Institute of Human Genetics, University of Utah, Salt Lake City, UT, USA., Huang X; Eccles Institute of Human Genetics, University of Utah, Salt Lake City, UT, USA., Greenland JA; Department of Oncological Sciences, University of Utah, Salt Lake City, UT, USA.; Huntsman Cancer Institute, University of Utah, Salt Lake City, UT, USA., Vahrenkamp JM; Department of Oncological Sciences, University of Utah, Salt Lake City, UT, USA.; Huntsman Cancer Institute, University of Utah, Salt Lake City, UT, USA., Lum DH; Huntsman Cancer Institute, University of Utah, Salt Lake City, UT, USA., Factor RE; Huntsman Cancer Institute, University of Utah, Salt Lake City, UT, USA.; Department of Pathology, University of Utah, Salt Lake City, UT, USA., Nelson EW; Huntsman Cancer Institute, University of Utah, Salt Lake City, UT, USA.; Department of Surgery, University of Utah, Salt Lake City, UT, USA., Matsen CB; Huntsman Cancer Institute, University of Utah, Salt Lake City, UT, USA.; Department of Surgery, University of Utah, Salt Lake City, UT, USA., Poretta JM; Huntsman Cancer Institute, University of Utah, Salt Lake City, UT, USA.; Department of Surgery, University of Utah, Salt Lake City, UT, USA., Rosenthal R; Huntsman Cancer Institute, University of Utah, Salt Lake City, UT, USA.; Department of Surgery, University of Utah, Salt Lake City, UT, USA., Beck AC; Huntsman Cancer Institute, University of Utah, Salt Lake City, UT, USA.; Department of Internal Medicine, Division of Medical Oncology, University of Utah, Salt Lake City, UT, USA., Buys SS; Huntsman Cancer Institute, University of Utah, Salt Lake City, UT, USA.; Department of Internal Medicine, Division of Medical Oncology, University of Utah, Salt Lake City, UT, USA., Vaklavas C; Huntsman Cancer Institute, University of Utah, Salt Lake City, UT, USA.; Department of Internal Medicine, Division of Medical Oncology, University of Utah, Salt Lake City, UT, USA., Ward JH; Huntsman Cancer Institute, University of Utah, Salt Lake City, UT, USA.; Department of Internal Medicine, Division of Medical Oncology, University of Utah, Salt Lake City, UT, USA., Jensen RL; Department of Oncological Sciences, University of Utah, Salt Lake City, UT, USA.; Huntsman Cancer Institute, University of Utah, Salt Lake City, UT, USA.; Department of Neurosurgery, University of Utah, Salt Lake City, UT, USA., Jones KB; Department of Oncological Sciences, University of Utah, Salt Lake City, UT, USA.; Huntsman Cancer Institute, University of Utah, Salt Lake City, UT, USA.; Department of Orthopaedics, University of Utah, Salt Lake City, UT, USA., Li Z; Department of Pharmacology and Chemical Biology, University of Pittsburgh, UPMC Hillman Cancer Center, Magee Womens Research Institute, Pittsburgh, PA, USA., Oesterreich S; Department of Pharmacology and Chemical Biology, University of Pittsburgh, UPMC Hillman Cancer Center, Magee Womens Research Institute, Pittsburgh, PA, USA., Dobrolecki LE; Lester and Sue Smith Breast Center, Baylor College of Medicine, Houston, TX, USA., Pathi SS; Department of Oncological Sciences, University of Utah, Salt Lake City, UT, USA.; Huntsman Cancer Institute, University of Utah, Salt Lake City, UT, USA., Woo XY; The Jackson Laboratory for Genomic Medicine, Farmington, CT, USA., Berrett KC; Department of Oncological Sciences, University of Utah, Salt Lake City, UT, USA.; Huntsman Cancer Institute, University of Utah, Salt Lake City, UT, USA., Wadsworth ME; Department of Oncological Sciences, University of Utah, Salt Lake City, UT, USA.; Huntsman Cancer Institute, University of Utah, Salt Lake City, UT, USA., Chuang JH; The Jackson Laboratory for Genomic Medicine, Farmington, CT, USA.; Department of Genetics and Genome Sciences, UCONN-Health, Farmington, CT, USA., Lewis MT; Lester and Sue Smith Breast Center, Baylor College of Medicine, Houston, TX, USA., Marth GT; Huntsman Cancer Institute, University of Utah, Salt Lake City, UT, USA.; Eccles Institute of Human Genetics, University of Utah, Salt Lake City, UT, USA., Gertz J; Department of Oncological Sciences, University of Utah, Salt Lake City, UT, USA.; Huntsman Cancer Institute, University of Utah, Salt Lake City, UT, USA., Varley KE; Department of Oncological Sciences, University of Utah, Salt Lake City, UT, USA.; Huntsman Cancer Institute, University of Utah, Salt Lake City, UT, USA., Welm BE; Huntsman Cancer Institute, University of Utah, Salt Lake City, UT, USA. bryan.welm@hci.utah.edu.; Department of Surgery, University of Utah, Salt Lake City, UT, USA. bryan.welm@hci.utah.edu., Welm AL; Department of Oncological Sciences, University of Utah, Salt Lake City, UT, USA. alana.welm@hci.utah.edu.; Huntsman Cancer Institute, University of Utah, Salt Lake City, UT, USA. alana.welm@hci.utah.edu.

Publikováno v: Nature cancer [Nat Cancer] 2022 Feb; Vol. 3 (2), pp. 232-250. Date of Electronic Publication: 2022 Feb 24.