Bystander Effects, Pharmacokinetics, and Linker-Payload Stability of EGFR-Targeting Antibody-Drug Conjugates Losatuxizumab Vedotin and Depatux-M in Glioblastoma Models.

Autor: Jain S; Department of Radiation Oncology, Mayo Clinic, Rochester, Minnesota., Griffith JI; Department of Pharmaceutics, University of Minnesota, Minneapolis, Minnesota., Porath KA; Department of Radiation Oncology, Mayo Clinic, Rochester, Minnesota., Rathi S; Department of Pharmaceutics, University of Minnesota, Minneapolis, Minnesota., Le J; Department of Pharmaceutics, University of Minnesota, Minneapolis, Minnesota., Pasa TI; Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, Minnesota., Decker PA; Department of Biomedical Statistics and Informatics, Mayo Clinic, Rochester, Minnesota., Gupta SK; Department of Radiation Oncology, Mayo Clinic, Rochester, Minnesota., Hu Z; Department of Radiation Oncology, Mayo Clinic, Rochester, Minnesota., Carlson BL; Department of Radiation Oncology, Mayo Clinic, Rochester, Minnesota., Bakken K; Department of Radiation Oncology, Mayo Clinic, Rochester, Minnesota., Burgenske DM; Department of Radiation Oncology, Mayo Clinic, Rochester, Minnesota., Feldsien TM; Development Sciences, AbbVie Inc., North Chicago, Illinois., Lefebvre DR; Development Sciences, AbbVie Inc., North Chicago, Illinois., Vaubel RA; Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, Minnesota., Eckel-Passow JE; Department of Biomedical Statistics and Informatics, Mayo Clinic, Rochester, Minnesota., Reilly EB; Discovery Oncology, AbbVie Inc., North Chicago, Illinois., Elmquist WF; Department of Pharmaceutics, University of Minnesota, Minneapolis, Minnesota., Sarkaria JN; Department of Radiation Oncology, Mayo Clinic, Rochester, Minnesota.

Publikováno v: Clinical cancer research : an official journal of the American Association for Cancer Research [Clin Cancer Res] 2024 Aug 01; Vol. 30 (15), pp. 3287-3297.

Convection enhanced delivery of EGFR targeting antibody-drug conjugates Serclutamab talirine and Depatux-M in glioblastoma patient-derived xenografts.

Autor: Porath KA; Department of Radiation Oncology, Mayo Clinic, Rochester, Minnesota, USA., Regan MS; Department of Neurosurgery, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA., Griffith JI; Brain Barriers Research Center, Department of Pharmaceutics, College of Pharmacy, University of Minnesota, Minneapolis, Minnesota, USA., Jain S; Department of Radiation Oncology, Mayo Clinic, Rochester, Minnesota, USA., Stopka SA; Department of Neurosurgery, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA.; Department of Radiology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA., Burgenske DM; Department of Radiation Oncology, Mayo Clinic, Rochester, Minnesota, USA., Bakken KK; Department of Radiation Oncology, Mayo Clinic, Rochester, Minnesota, USA., Carlson BL; Department of Radiation Oncology, Mayo Clinic, Rochester, Minnesota, USA., Decker PA; Department of Quantitative Health Sciences, Mayo Clinic, Rochester, Minnesota, USA., Vaubel RA; Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, Minnesota, USA., Dragojevic S; Department of Radiation Oncology, Mayo Clinic, Rochester, Minnesota, USA., Mladek AC; Department of Radiation Oncology, Mayo Clinic, Rochester, Minnesota, USA., Connors MA; Department of Radiation Oncology, Mayo Clinic, Rochester, Minnesota, USA., Hu Z; Department of Radiation Oncology, Mayo Clinic, Rochester, Minnesota, USA., He L; Department of Radiation Oncology, Mayo Clinic, Rochester, Minnesota, USA., Kitange GJ; Department of Radiation Oncology, Mayo Clinic, Rochester, Minnesota, USA., Gupta SK; Department of Radiation Oncology, Mayo Clinic, Rochester, Minnesota, USA., Feldsien TM; Development Sciences, AbbVie Inc., North Chicago, Illinois, USA., Lefebvre DR; Development Sciences, AbbVie Inc., North Chicago, Illinois, USA., Agar NYR; Department of Neurosurgery, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA.; Department of Radiology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.; Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, Massachusetts, USA., Eckel-Passow JE; Department of Quantitative Health Sciences, Mayo Clinic, Rochester, Minnesota, USA., Reilly EB; Discovery Oncology, AbbVie Inc., North Chicago, Illinois, USA., Elmquist WF; Brain Barriers Research Center, Department of Pharmaceutics, College of Pharmacy, University of Minnesota, Minneapolis, Minnesota, USA., Sarkaria JN; Department of Radiation Oncology, Mayo Clinic, Rochester, Minnesota, USA.

Publikováno v: Neuro-oncology advances [Neurooncol Adv] 2022 Aug 24; Vol. 4 (1), pp. vdac130. Date of Electronic Publication: 2022 Aug 24 (Print Publication: 2022).

Heterogeneous delivery across the blood-brain barrier limits the efficacy of an EGFR-targeting antibody drug conjugate in glioblastoma.

Autor: Marin BM; Department of Radiation Oncology, Mayo Clinic, Rochester, Minnesota, USA., Porath KA; Department of Radiation Oncology, Mayo Clinic, Rochester, Minnesota, USA., Jain S; Department of Radiation Oncology, Mayo Clinic, Rochester, Minnesota, USA., Kim M; Department of Pharmaceutics, University of Minnesota, Minneapolis, Minnesota, USA., Conage-Pough JE; Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, Massachusetts, USA.; David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, Massachusetts, USA.; Center for Precision Cancer Medicine, Massachusetts Institute of Technology, Cambridge, Massachusetts, USA., Oh JH; Department of Pharmaceutics, University of Minnesota, Minneapolis, Minnesota, USA., Miller CL; Department of Bioengineering, Stanford University, Stanford, California, USA., Talele S; Department of Pharmaceutics, University of Minnesota, Minneapolis, Minnesota, USA., Kitange GJ; Department of Radiation Oncology, Mayo Clinic, Rochester, Minnesota, USA., Tian S; Department of Biomedical Statistics and Informatics, Mayo Clinic, Rochester, Minnesota, USA., Burgenske DM; Department of Radiation Oncology, Mayo Clinic, Rochester, Minnesota, USA., Mladek AC; Department of Radiation Oncology, Mayo Clinic, Rochester, Minnesota, USA., Gupta SK; Department of Radiation Oncology, Mayo Clinic, Rochester, Minnesota, USA., Decker PA; Department of Biomedical Statistics and Informatics, Mayo Clinic, Rochester, Minnesota, USA., McMinn MH; Department of Neurosurgery, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA.; Department of Chemistry and Chemical Biology, Northeastern University, Boston, Massachusetts, USA., Stopka SA; Department of Neurosurgery, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA.; Department of Radiology, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA., Regan MS; Department of Neurosurgery, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA., He L; Department of Radiation Oncology, Mayo Clinic, Rochester, Minnesota, USA., Carlson BL; Department of Radiation Oncology, Mayo Clinic, Rochester, Minnesota, USA., Bakken K; Department of Radiation Oncology, Mayo Clinic, Rochester, Minnesota, USA., Burns TC; Department of Neurosurgery, Mayo Clinic, Rochester, Minnesota, USA., Parney IF; Department of Neurosurgery, Mayo Clinic, Rochester, Minnesota, USA., Giannini C; Department of Laboratory Medicine and Pathology; Mayo Clinic, Rochester, Minnesota, USA., Agar NYR; Department of Neurosurgery, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA.; Department of Radiology, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA.; Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, Massachusetts, USA., Eckel-Passow JE; Department of Biomedical Statistics and Informatics, Mayo Clinic, Rochester, Minnesota, USA., Cochran JR; Department of Bioengineering, Stanford University, Stanford, California, USA., Elmquist WF; Department of Pharmaceutics, University of Minnesota, Minneapolis, Minnesota, USA., Vaubel RA; Department of Laboratory Medicine and Pathology; Mayo Clinic, Rochester, Minnesota, USA., White FM; Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, Massachusetts, USA.; David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, Massachusetts, USA.; Center for Precision Cancer Medicine, Massachusetts Institute of Technology, Cambridge, Massachusetts, USA., Sarkaria JN; Department of Radiation Oncology, Mayo Clinic, Rochester, Minnesota, USA.

Publikováno v: Neuro-oncology [Neuro Oncol] 2021 Dec 01; Vol. 23 (12), pp. 2042-2053.