Trans-ancestry genome-wide association meta-analysis of prostate cancer identifies new susceptibility loci and informs genetic risk prediction

Autor: Paul A. Townsend, Edward J. Saunders, Hidewaki Nakagawa, Manuel R. Teixeira, Graham Casey, Demetrius Albanes, Christine Neslund-Dudas, Sara Lindström, William S. Bush, Maren Weischer, Lisa A. Cannon-Albright, Rick A. Kittles, Peggy Wan, Martin Eklund, Stephen N. Thibodeau, Burcu F. Darst, Fredrik Wiklund, Nicholas Mancuso, Jeri Kim, Jong Y. Park, Johanna Schleutker, Maureen Sanderson, Samantha E.T. Larkin, Radka Kaneva, Hongwei Zhang, Daniel J. Schaid, Luc Multigner, Marie-Élise Parent, Robert Szulkin, Fredrick R. Schumacher, Geraldine Cancel-Tassin, Jianfeng Xu, Gill Barnett, Melissa C. Southey, Yuan Chun Ding, Alexander Lubwama, Maria Elena Martinez, Manolis Kogevinas, Linda Steele, Laurent Brureau, Shiv Srivastava, Maya Ghoussaini, Alison M. Dunning, Adam B. Murphy, Kenneth Muir, Edward Giovannucci, Mitchell J. Machiela, James L. Mohler, Jack A. Taylor, Robert N. Hoover, Sandeep Singhal, Chavdar Slavov, Guido Jenster, Frank Claessens, Neil Fleshner, Sara Benlloch, Gert De Meerleer, Michael B. Cook, Zan Sun, Harry Ostrer, Pascal Blanchet, Lynne R. Wilkens, Ali Amin Al Olama, Sue A. Ingles, Markus Aly, Jay H. Fowke, Agnieszka Michael, Yves Akoli Koudou, Victoria L. Stevens, Kathryn L. Penney, Ana Vega, Xin Sheng, Ron H.N. van Schaik, Zsofia Kote-Jarai, Kim De Ruyck, Christopher A. Haiman, Atushi Takahashi, Florence Menegaux, Judith A. Clements, Stephen K. Van Den Eeden, Brian D. Carter, Wayne D. Tilley, Antonio Finelli, Jennifer J. Hu, Hermann Brenner, Thomas Van den Broeck, Shan Chao Zhao, Azad Hassan Abdul Razack, Edward D. Yeboah, Sonja I. Berndt, Barbara Nemesure, Mark N. Brook, David V. Conti, Katarina Cuk, Teuvo L.J. Tammela, Ali Sahimi, Stephen J. Chanock, Loic Le Marchand, Gemma Castaño-Vinyals, Sune F. Nielsen, Sara S. Strom, Ann W. Hsing, Roberta McKean-Cowdin, David J. Hunter, Ian M. Thompson, Børge G. Nordestgaard, Jyotsna Batra, Paula Paulo, Masashi Fujita, Jennifer Cullen, Susan M. Gapstur, Sarah L. Kerns, Lorelei A. Mucci, Neil G. Burnet, Xueying Mao, Hui Yi Lin, Rohit Varma, Marija Gamulin, Wei Zheng, Thomas A. Sellers, Adam S. Kibel, Robert J. Hamilton, Leire Moya, Ninghan Feng, Laura E. Beane Freeman, James E. Mensah, Catherine M. Tangen, Shannon K. McDonnell, Matthew Parliament, Davor Lessel, Gail P. Risbridger, Mina Torres, Janet L. Stanford, Bettina F. Drake, Soo-Hwang Teo, Robert J. MacInnis, Stig E. Bojesen, Jeannette T. Bensen, William J. Blot, Stella Koutros, Robin J. Leach, Graham G. Giles, Piet Ost, Artitaya Lophatananon, Laura Fachal, Tomislav Kuliš, Peter Kraft, Monique J. Roobol, Elaine A. Ostrander, Niclas Håkansson, Anselm Hennis, Yukihide Momozawa, Anssi Auvinen, Koichi Matsuda, Steven Joniau, Lisa G. Horvath, Javier Llorca, Claire Aukim-Hastie, Bernd Holleczek, Daniel W. Lin, Gerald L. Andriole, John D. Carpten, Eli Marie Grindedal, Rosalind A. Eeles, Elio Riboli, Constance Turman, Martin Andreas Røder, Yong-Jie Lu, Tobias Nordström, Kai Uwe Saum, Esther M. John, Melinda C. Aldrich, Peter Iversen, Henrik Grönberg, John S. Witte, Andreia Brandão, Eric A. Klein, Olivier Cussenot, Barry S. Rosenstein, Stephen Watya, Jan Lubinski, Douglas F. Easton, Dana C. Crawford, Gyorgy Petrovics, Thomas J. Schnoeller, Richard M. Martin, Stephanie J. Weinstein, Jose Esteban Castelao, Suzanne K. Chambers, Tokhir Dadaev, Karina Dalsgaard Sørensen, Antonio Gómez-Caamaño, Lisa F. Newcomb, Csilla Sipeky, Lovise Maehle, Brandi Weaver, Susan L. Neuhausen, Christiane Maier, Alicja Wolk, Vanio Mitev, Thérèse Truong, Manuel Luedeke, Jenny L Donovan, Mariana C. Stern, Catharine M L West, Manuela Gago-Dominguez, Elizabeth T. H. Fontham, William B. Isaacs, David E. Neal, Christopher J. Logothetis, Alisha Chou, Jasmine Lim, Benjamin A. Rybicki, Kay-Tee Khaw, Meir J. Stampfer, Chad D. Huff, Thomas J. Hoffmann, Michael Borre, Freddie C. Hamdy, Nawaid Usmani, Cezary Cybulski, Craig C. Teerlink, Milan S. Geybels, Nora Pashayan, Timothy J. Key, Phyllis J. Goodman, Hardev Pandha, Ruth C. Travis, Yudong Wu, Dominika Wokołorczyk, Lilit C. Moss

Publikováno v: Conti, D V, Darst, B F, Moss, L C, Saunders, E J, Sheng, X, Chou, A, Schumacher, F R, Olama, A A A, Benlloch, S, Dadaev, T, Brook, M N, Sahimi, A, Hoffmann, T J, Takahashi, A, Matsuda, K, Momozawa, Y, Fujita, M, Muir, K, Lophatananon, A, Wan, P, Le Marchand, L, Wilkens, L R, Stevens, V L, Gapstur, S M, Carter, B D, Schleutker, J, Tammela, T L J, Sipeky, C, Auvinen, A, Giles, G G, Southey, M C, MacInnis, R J, Cybulski, C, Wokołorczyk, D, Lubiński, J, Neal, D E, Donovan, J L, Hamdy, F C, Martin, R M, Nordestgaard, B G, Nielsen, S F, Weischer, M, Bojesen, S E, Røder, M A, Iversen, P, Batra, J, Chambers, S, Moya, L, Horvath, L, Clements, J A, Tilley, W, Risbridger, G P, Gronberg, H, Aly, M, Szulkin, R, Eklund, M, Nordström, T, Pashayan, N, Dunning, A M, Ghoussaini, M, Travis, R C, Key, T J, Riboli, E, Park, J Y, Sellers, T A, Lin, H-Y, Albanes, D, Weinstein, S J, Mucci, L A, Giovannucci, E, Lindstrom, S, Kraft, P, Hunter, D J, Penney, K L, Turman, C, Tangen, C M, Goodman, P J, Thompson, I M, Hamilton, R J, Fleshner, N E, Finelli, A, Parent, M-É, Stanford, J L, Ostrander, E A, Geybels, M S, Koutros, S, Freeman, L E B, Stampfer, M, Wolk, A, Håkansson, N, Andriole, G L, Hoover, R N, Machiela, M J, Sørensen, K D, Borre, M, Blot, W J, Zheng, W, Yeboah, E D, Mensah, J E, Lu, Y-J, Zhang, H-W, Feng, N, Mao, X, Wu, Y, Zhao, S-C, Sun, Z, Thibodeau, S N, McDonnell, S K, Schaid, D J, West, C M L, Burnet, N, Barnett, G, Maier, C, Schnoeller, T, Luedeke, M, Kibel, A S, Drake, B F, Cussenot, O, Cancel-Tassin, G, Menegaux, F, Truong, T, Koudou, Y A, John, E M, Grindedal, E M, Maehle, L, Khaw, K-T, Ingles, S A, Stern, M C, Vega, A, Gómez-Caamaño, A, Fachal, L, Rosenstein, B S, Kerns, S L, Ostrer, H, Teixeira, M R, Paulo, P, Brandão, A, Watya, S, Lubwama, A, Bensen, J T, Fontham, E T H, Mohler, J, Taylor, J A, Kogevinas, M, Llorca, J, Castaño-Vinyals, G, Cannon-Albright, L, Teerlink, C C, Huff, C D, Strom, S S, Multigner, L, Blanchet, P, Brureau, L, Kaneva, R, Slavov, C, Mitev, V, Leach, R J, Weaver, B, Brenner, H, Cuk, K, Holleczek, B, Saum, K-U, Klein, E A, Hsing, A W, Kittles, R A, Murphy, A B, Logothetis, C J, Kim, J, Neuhausen, S L, Steele, L, Ding, Y C, Isaacs, W B, Nemesure, B, Hennis, A J M, Carpten, J, Pandha, H, Michael, A, De Ruyck, K, De Meerleer, G, Ost, P, Xu, J, Razack, A, Lim, J, Teo, S-H, Newcomb, L F, Lin, D W, Fowke, J H, Neslund-Dudas, C, Rybicki, B A, Gamulin, M, Lessel, D, Kulis, T, Usmani, N, Singhal, S, Parliament, M, Claessens, F, Joniau, S, Van den Broeck, T, Gago-Dominguez, M, Castelao, J E, Martinez, M E, Larkin, S, Townsend, P A, Aukim-Hastie, C, Bush, W S, Aldrich, M C, Crawford, D C, Srivastava, S, Cullen, J C, Petrovics, G, Casey, G, Roobol, M J, Jenster, G, van Schaik, R H N, Hu, J J, Sanderson, M, Varma, R, McKean-Cowdin, R, Torres, M, Mancuso, N, Berndt, S I, Van Den Eeden, S K, Easton, D F, Chanock, S J, Cook, M B, Wiklund, F, Nakagawa, H, Witte, J S, Eeles, R A, Kote-Jarai, Z & Haiman, C A 2021, ' Trans-ancestry genome-wide association meta-analysis of prostate cancer identifies new susceptibility loci and informs genetic risk prediction ', Nature Genetics, vol. 53, no. 1, pp. 65-75 . https://doi.org/10.1038/s41588-020-00748-0
Nature Genetics
Nature Genetics, Nature Publishing Group, 2021, 53 (1), pp.65-75. ⟨10.1038/s41588-020-00748-0⟩
Nature Genetics, 2021, 53 (1), pp.65-75. ⟨10.1038/s41588-020-00748-0⟩
Conti, D V, Donovan, J L, Martin, R M, Haiman, C A & al., E 2021, ' Trans-ancestry genome-wide association meta-analysis of prostate cancer identifies new susceptibility loci and informs genetic risk prediction ', Nature Genetics, vol. 53, no. 1, pp. 65–75 . https://doi.org/10.1038/s41588-020-00748-0
Nature Genetics, 53(1), 65-75. Nature Publishing Group
Conti, D V, Darst, B F, Moss, L C, Saunders, E J, Sheng, X, Chou, A, Schumacher, F R, Olama, A A A, Benlloch, S, Dadaev, T, Brook, M N, Sahimi, A, Hoffmann, T J, Takahashi, A, Matsuda, K, Momozawa, Y, Fujita, M, Muir, K, Lophatananon, A, Wan, P, Le Marchand, L, Wilkens, L R, Stevens, V L, Gapstur, S M, Carter, B D, Schleutker, J, Tammela, T L J, Sipeky, C, Auvinen, A, Giles, G G, Southey, M C, MacInnis, R J, Cybulski, C, Wokołorczyk, D, Lubiński, J, Neal, D E, Donovan, J L, Hamdy, F C, Martin, R M, Nordestgaard, B G, Nielsen, S F, Weischer, M, Bojesen, S E, Røder, M A, Iversen, P, Batra, J, Chambers, S, Moya, L, Horvath, L, Clements, J A, Tilley, W, Risbridger, G P, Gronberg, H, Aly, M, Szulkin, R, Eklund, M, Nordström, T, Pashayan, N, Dunning, A M, Ghoussaini, M, Travis, R C, Key, T J, Riboli, E, Park, J Y, Sellers, T A, Lin, H Y, Albanes, D, Weinstein, S J, Mucci, L A, Giovannucci, E, Lindstrom, S, Kraft, P, Hunter, D J, Penney, K L, Turman, C, Tangen, C M, Goodman, P J, Thompson, I M, Hamilton, R J, Fleshner, N E, Finelli, A, Parent, M É, Stanford, J L, Ostrander, E A, Geybels, M S, Koutros, S, Freeman, L E B, Stampfer, M, Wolk, A, Håkansson, N, Andriole, G L, Hoover, R N, Machiela, M J, Sørensen, K D, Borre, M, Blot, W J, Zheng, W, Yeboah, E D, Mensah, J E, Lu, Y J, Zhang, H W, Feng, N, Mao, X, Wu, Y, Zhao, S C, Sun, Z, Thibodeau, S N, McDonnell, S K, Schaid, D J, West, C M L, Burnet, N, Barnett, G, Maier, C, Schnoeller, T, Luedeke, M, Kibel, A S, Drake, B F, Cussenot, O, Cancel-Tassin, G, Menegaux, F, Truong, T, Koudou, Y A, John, E M, Grindedal, E M, Maehle, L, Khaw, K T, Ingles, S A, Stern, M C, Vega, A, Gómez-Caamaño, A, Fachal, L, Rosenstein, B S, Kerns, S L, Ostrer, H, Teixeira, M R, Paulo, P, Brandão, A, Watya, S, Lubwama, A, Bensen, J T, Fontham, E T H, Mohler, J, Taylor, J A, Kogevinas, M, Llorca, J, Castaño-Vinyals, G, Cannon-Albright, L, Teerlink, C C, Huff, C D, Strom, S S, Multigner, L, Blanchet, P, Brureau, L, Kaneva, R, Slavov, C, Mitev, V, Leach, R J, Weaver, B, Brenner, H, Cuk, K, Holleczek, B, Saum, K U, Klein, E A, Hsing, A W, Kittles, R A, Murphy, A B, Logothetis, C J, Kim, J, Neuhausen, S L, Steele, L, Ding, Y C, Isaacs, W B, Nemesure, B, Hennis, A J M, Carpten, J, Pandha, H, Michael, A, De Ruyck, K, De Meerleer, G, Ost, P, Xu, J, Razack, A, Lim, J, Teo, S H, Newcomb, L F, Lin, D W, Fowke, J H, Neslund-Dudas, C, Rybicki, B A, Gamulin, M, Lessel, D, Kulis, T, Usmani, N, Singhal, S, Parliament, M, Claessens, F, Joniau, S, Van den Broeck, T, Gago-Dominguez, M, Castelao, J E, Martinez, M E, Larkin, S, Townsend, P A, Aukim-Hastie, C, Bush, W S, Aldrich, M C, Crawford, D C, Srivastava, S, Cullen, J C, Petrovics, G, Casey, G, Roobol, M J, Jenster, G, van Schaik, R H N, Hu, J J, Sanderson, M, Varma, R, McKean-Cowdin, R, Torres, M, Mancuso, N, Berndt, S I, Van Den Eeden, S K, Easton, D F, Chanock, S J, Cook, M B, Wiklund, F, Nakagawa, H, Witte, J S, Eeles, R A, Kote-Jarai, Z & Haiman, C A 2021, ' Trans-ancestry genome-wide association meta-analysis of prostate cancer identifies new susceptibility loci and informs genetic risk prediction ', Nature Genetics, vol. 53, no. 1, pp. 65-75 . https://doi.org/10.1038/s41588-020-00748-0
Nature genetics

International audience; Prostate cancer is a highly heritable disease with large disparities in incidence rates across ancestry populations. We conducted a multiancestry meta-analysis of prostate cancer genome-wide association studies (107,247 cases

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1a27e581a69c75f35d954ecb341f4f49
http://hdl.handle.net/10230/52213

Novel genetic associations for blood pressure identified via gene-alcohol interaction in up to 570K individuals across multiple ancestries

Autor: Rico Rueedi, Yuri Milaneschi, Brenda W.J.H. Penninx, Neil Poulter, Karen Schwander, Marco Brumat, Kenneth Rice, Yize Li, Veronique Vitart, Ioanna Ntalla, Michele K. Evans, Jeffrey R. O'Connell, Nilesh J. Samani, Colleen M. Sitlani, W. James Gauderman, Xuan Deng, Paul M. Ridker, Yun J. Sung, Yukihide Momozawa, Archie Campbell, Tin Louie, Nona Sotoodehnia, Yii-Der Ida Chen, Cornelia M. van Duijn, Tanika N. Kelly, Peter S. Sever, André G. Uitterlinden, Brigitte Kühnel, John M. Starr, Lawrence F. Bielak, Christopher P. Nelson, Wanqing Wen, Stephan B. Felix, Stefan Weiss, Daniel Levy, Nicholette D. Palmer, Alisa K. Manning, Salman M. Tajuddin, Jill M. Norris, Marie Loh, M. Abdullah Said, Alena Stančáková, Anuradhani Kasturiratne, John M. C. Connell, Jian'an Luan, Tuomas O. Kilpeläinen, Amy R. Bentley, Stephen Sidney, Alan B. Zonderman, Karin Leander, David J. Porteous, Jianjun Liu, Tin Aung, Charles B. Eaton, Sharon L.R. Kardia, Rajkumar Dorajoo, Stephen Turner, Michael Boehnke, Diane M. Becker, Cora E. Lewis, Ozren Polasek, Mickaël Canouil, Kurt Lohman, Georg Ehret, Sarah E. Harris, Robert A. Scott, Claude Bouchard, Lynne E. Wagenknecht, Mohsen Ghanbari, Stephen B. Kritchevsky, Jin-Fang Chai, Gregory L. Burke, Jiang He, Federica Laguzzi, Michael R. Brown, Walter Palmas, Lili Milani, Thomas T. Perls, Tibor V. Varga, José Eduardo Krieger, Erin B. Ware, Tamara B. Harris, Tomohiro Katsuya, Nicole Schupf, Mika Kähönen, Nana Matoba, Hugues Aschard, Ilaria Gandin, Jennifer A. Smith, Traci M. Bartz, James Scott, Tuomo Rankinen, Yuan Shi, Meian He, Timo A. Lakka, Helen R. Warren, Mike A. Nalls, Kent D. Taylor, Woon-Puay Koh, Ya Xing Wang, Muhammad Riaz, Sandosh Padmanabhan, Mary F. Feitosa, Jost B. Jonas, Paul Elliott, Christian Gieger, Terho Lehtimäki, Kaare Christensen, Maris Alver, Pirjo Komulainen, Pamela J. Schreiner, M. Arfan Ikram, David R. Weir, Charles Kooperberg, Oscar H. Franco, Yongmei Liu, Lisa de las Fuentes, Nancy L. Pedersen, Thomas W. Winkler, Bruna Gigante, Göran Hallmans, Ingrid B. Borecki, Shiow Lin, Ian J. Deary, Wei Zheng, Yajuan Wang, Bernardo L. Horta, Heather M. Stringham, Bruce M. Psaty, Paul W. Franks, Weihua Zhang, Nora Franceschini, Adolfo Correa, Nita G. Forouhi, Xiuqing Guo, Fumihiko Takeuchi, L. Adrienne Cupples, William R. Scott, Zoltán Kutalik, He Gao, Nicholas J. Wareham, E. Shyong Tai, Aravinda Chakravarti, C. Charles Gu, Paolo Gasparini, Albertine J. Oldehinkel, Xueling Sim, Norihiro Kato, Evangelos Evangelou, Philippe Froguel, Colin A. McKenzie, Qing Duan, Aldi T. Kraja, Carsten Oliver Schmidt, Bamidele O. Tayo, Xiaofeng Zhu, Thomas Meitinger, Mary K. Wojczynski, Markku Laakso, Mark J. Caulfield, Carl D. Langefeld, Jingzhong Ding, Yechiel Friedlander, Tien Yin Wong, Virginia Fisher, Raymond Noordam, Caizheng Yu, Pim van der Harst, Yik Ying Teo, Ervin R. Fox, Sabanayagam Charumathi, Jonathan Marten, Nicholas Y.Q. Tan, Jerome I. Rotter, Harold Snieder, Karen L. Mohlke, Christine Williams, Olli T. Raitakari, Renée de Mutsert, Lihua Wang, Kathryn Roll, Jingmin Liu, Dongfeng Gu, Wei Zhao, Lynda M. Rose, Michael A. Province, Fernando Pires Hartwig, Rob M. van Dam, Barry I. Freedman, Andres Metspalu, Donald W. Bowden, Andrea R. V. R. Horimoto, Martin Farrall, Frits R. Rosendaal, Rainer Rauramaa, Konstantin Strauch, Albert V. Smith, Yanick Hagemeijer, Michiaki Kubo, Ilja M. Nolte, Tõnu Esko, Yih Chung Tham, Cathy C. Laurie, Antonietta Robino, Anne U. Jackson, Chuan Gao, Dabeeru C. Rao, Xiao-Ou Shu, H. Janaka de Silva, Morris J. Brown, Alanna C. Morrison, Peter J. van der Most, Jian-Min Yuan, Melanie Waldenberger, Leslie J. Raffel, Ulrich John, Fang-Chi Hsu, Reedik Mägi, Solomon K. Musani, Chiea Chuen Khor, Mario Sims, Ruben N. Eppinga, Melissa A. Richard, Yoichiro Kamatani, Changwei Li, Qiuyin Cai, Daniel I. Chasman, Mathilde Boissel, Claudia Langenberg, Sami Heikkinen, Jasmin Divers, Saima Afaq, Wen Bin Wei, Jaspal S. Kooner, Terrence Forrester, Hua Tang, Charles N. Rotimi, Anuj Goel, Annette Peters, Tangchun Wu, Dennis O. Mook-Kanamori, Caroline Hayward, Ching-Yu Cheng, Lisa R. Yanek, Ananda R. Wickremasinghe, Chew-Kiat Heng, Myriam Fornage, Dina Vojinovic, Najaf Amin, Lenore J. Launer, Hugh Watkins, Johanna Kuusisto, Jing Hua Zhao, Barbara V. Howard, Vilmundur Gudnason, Ulrich Broeckel, Eric Boerwinkle, Saskia P. Hagenaars, Dan E. Arking, Peter Vollenweider, Alexandre C. Pereira, Jie Yao, Makoto Hirata, Patricia B. Munroe, Patricia A. Peyser, Jessica D. Faul, Xu Chen, Patrik K. E. Magnusson, John C. Chambers, Tamar Sofer, Marzyeh Amini, Benjamin Lehne

Publikováno v: Feitosa, M F, Kraja, A T, Chasman, D I, Sung, Y J, Winkler, T W, Ntalla, I, Guo, X, Franceschini, N, Cheng, C-Y, Sim, X, Vojinovic, D, Marten, J, Musani, S K, Li, C, Bentley, A R, Brown, M R, Schwander, K, Richard, M A, Noordam, R, Aschard, H, Bartz, T M, Bielak, L F, Dorajoo, R, Fisher, V, Hartwig, F P, Horimoto, A R V R, Lohman, K K, Manning, A K, Rankinen, T, Smith, A V, Tajuddin, S M, Wojczynski, M K, Alver, M, Boissel, M, Cai, Q, Campbell, A, Chai, J F, Chen, X, Divers, J, Gao, C, Goel, A, Hagemeijer, Y, Harris, S E, He, M, Hsu, F-C, Jackson, A U, Kähönen, M, Zhao, J H, Kilpeläinen, T O, Christensen, K & V Varga, T 2018, ' Novel genetic associations for blood pressure identified via gene-alcohol interaction in up to 570K individuals across multiple ancestries ', PLoS ONE, vol. 13, no. 6, e0198166, pp. 1-36 . https://doi.org/10.1371/journal.pone.0198166
Feitosa, M F, Kraja, A T, Chasman, D I, Sung, Y J, Winkler, T W, Ntalla, I, Guo, X, Franceschini, N, Cheng, C Y, Sim, X, Vojinovic, D, Marten, J, Musani, S K, Li, C, Bentley, A R, Brown, M R, Schwander, K, Richard, M A, Noordam, R, Aschard, H, Bartz, T M, Bielak, L F, Dorajoo, R, Fisher, V, Hartwig, F P, Horimoto, A R V R, Lohman, K K, Manning, A K, Rankinen, T, Smith, A V, Tajuddin, S M, Wojczynski, M K, Alver, M, Boissel, M, Cai, Q, Campbell, A, Chai, J F, Chen, X, Divers, J, Gao, C, Goel, A, Hagemeijer, Y, Harris, S E, He, M, Hsu, F C, Jackson, A U, Kähönen, M, Kasturiratne, A, Komulainen, P, Kühnel, B, Laguzzi, F, Luan, JA, Matoba, N, Nolte, I M, Padmanabhan, S, Riaz, M, Rueedi, R, Robino, A, Said, M A, Scott, R A, Sofer, T, Stančáková, A, Takeuchi, F, Tayo, B O, Van Der Most, P J, Varga, T V, Vitart, V, Wang, Y, Ware, E B, Warren, H R, Weiss, S, Wen, W, Yanek, L R, Zhang, W, Zhao, J H, Afaq, S, Amin, N, Amini, M, Arking, D E, Aung, T, Boerwinkle, E, Borecki, I, Broeckel, U, Brown, M, Brumat, M, Burke, G L, Canouil, M, Chakravarti, A, Charumathi, S, Chen, Y D I, Connell, J M, Correa, A, De Las Fuentes, L, De Mutsert, R, De Silva, H J, Deng, X, Ding, J, Duan, Q, Eaton, C B, Ehret, G, Eppinga, R N, Evangelou, E, Faul, J D, Felix, S B, Forouhi, N G, Forrester, T, Franco, O H, Friedlander, Y, Gandin, I, Gao, H, Ghanbari, M, Gigante, B, Gu, C C, Gu, D, Hagenaars, S P, Hallmans, G, Harris, T B, He, J, Heikkinen, S, Heng, C K, Hirata, M, Howard, B V, Ikram, M A, John, U, Katsuya, T, Khor, C C, Kilpeläinen, T O, Koh, W P, Krieger, J E, Kritchevsky, S B, Kubo, M, Kuusisto, J, Lakka, T A, Langefeld, C D, Langenberg, C, Launer, L J, Lehne, B, Lewis, C E, Li, Y, Lin, S, Liu, J, Liu, J, Loh, M, Louie, T, Mägi, R, McKenzie, C A, Meitinger, T, Metspalu, A, Milaneschi, Y, Milani, L, Mohlke, K L, Momozawa, Y, Nalls, M A, Nelson, C P, Sotoodehnia, N, Norris, J M, O'Connell, J R, Palmer, N D, Perls, T, Pedersen, N L, Peters, A, Peyser, P A, Poulter, N, Raffel, L J, Raitakari, O T, Roll, K, Rose, L M, Rosendaal, F R, Rotter, J I, Schmidt, C O, Schreiner, P J, Schupf, N, Scott, W R, Sever, P S, Shi, Y, Sidney, S, Sims, M, Sitlani, C M, Smith, J A, Snieder, H, Starr, J M, Strauch, K, Stringham, H M, Tan, N Y Q, Tang, H, Taylor, K D, Teo, Y Y, Tham, Y C, Turner, S T, Uitterlinden, A G, Vollenweider, P, Waldenberger, M, Wang, L, Wang, Y X, Wei, W B, Williams, C, Yao, J, Yu, C, Yuan, J M, Zhao, W, Zonderman, A B, Becker, D M, Boehnke, M, Bowden, D W, Chambers, J C, Deary, I J, Esko, T, Farrall, M, Franks, P W, Freedman, B I, Froguel, P, Gasparini, P, Gieger, C, Jonas, J B, Kamatani, Y, Kato, N, Kooner, J S, Kutalik, Z, Laakso, M, Laurie, C C, Leander, K, Lehtimäki, T, Magnusson, P K E, Oldehinkel, A J, Penninx, B W J H, Polasek, O, Porteous, D J, Rauramaa, R, Samani, N J, Scott, J, Shu, X O, Van Der Harst, P, Wagenknecht, L E, Wareham, N J, Watkins, H, Weir, D R, Wickremasinghe, A R, Wu, T, Zheng, W, Bouchard, C, Christensen, K, Evans, M K, Gudnason, V, Horta, B L, Kardia, S L R, Liu, Y, Pereira, A C, Psaty, B M, Ridker, P M, Van Dam, R M, Gauderman, W J, Zhu, X, Mook-Kanamori, D O, Fornage, M, Rotimi, C N, Cupples, L A, Kelly, T N, Fox, E R, Hayward, C, Van Duijn, C M, Tai, E S, Wong, T Y, Kooperberg, C, Palmas, W, Rice, K, Morrison, A C, Elliott, P, Caulfield, M J, Munroe, P B, Rao, D C, Province, M A & Levy, D 2018, ' Novel genetic associations for blood pressure identified via gene-alcohol interaction in up to 570K individuals across multiple ancestries ', PLoS ONE, vol. 13, no. 6, e0198166 . https://doi.org/10.1371/journal.pone.0198166
Feitosa, M F, Kraja, A T, Chasman, D I, Sung, Y J, Winkler, T W, Ntalla, I, Guo, X, Franceschini, N, Cheng, C, Sim, X, Vojinovic, D, Marten, J, Musani, S K, Li, C, Bentley, A R, Brown, M R, Schwander, K, Richard, M A, Noordam, R, Aschard, H, Bartz, T M, Bielak, L F, Dorajoo, R, Fisher, V, Hartwig, F P, Horimoto, A R V R, Lohman, K K, Manning, A K, Rankinen, T, Smith, A V, Tajuddin, S M, Wojczynski, M K, Alver, M, Boissel, M, Cai, Q, Campbell, A, Chai, J F, Chen, X, Divers, J, Gao, C, Goel, A, Hagemeijer, Y, Harris, S E, He, M, Hsu, F, Jackson, A U, Kähönen, M, Kasturiratne, A, Komulainen, P, Kühnel, B, Laguzzi, F, Luan, J, Matoba, N, Nolte, I M, Padmanabhan, S, Riaz, M, Rueedi, R, Robino, A, Said, M A, Scott, R A, Sofer, T, Stančáková, A, Takeuchi, F, Tayo, B O, Van Der Most, P J, Varga, T V, Vitart, V, Wang, Y, Ware, E B, Warren, H R, Weiss, S, Wen, W, Yanek, L R, Zhang, W, Zhao, J H, Afaq, S, Amin, N, Amini, M, Arking, D E, Aung, T, Boerwinkle, E, Borecki, I, Broeckel, U, Brown, M, Brumat, M, Burke, G L, Canouil, M, Chakravarti, A, Charumathi, S, Ida Chen, Y, Connell, J M, Correa, A, De Las Fuentes, L, De Mutsert, R, De Silva, H J, Deng, X, Ding, J, Duan, Q, Eaton, C B, Ehret, G, Eppinga, R N, Evangelou, E, Faul, J D, Felix, S B, Forouhi, N G, Forrester, T, Franco, O H, Friedlander, Y, Gandin, I, Gao, H, Ghanbari, M, Gigante, B, Gu, C C, Gu, D, Hagenaars, S P, Hallmans, G, Harris, T B, He, J, Heikkinen, S, Heng, C, Hirata, M, Howard, B V, Ikram, M A, John, U, Katsuya, T, Khor, C C, Kilpeläinen, T O, Koh, W, Krieger, J E, Kritchevsky, S B, Kubo, M, Kuusisto, J, Lakka, T A, Langefeld, C D, Langenberg, C, Launer, L J, Lehne, B, Lewis, C E, Li, Y, Lin, S, Liu, J, Liu, J, Loh, M, Louie, T, Mägi, R, Mckenzie, C A, Meitinger, T, Metspalu, A, Milaneschi, Y, Milani, L, Mohlke, K L, Momozawa, Y, Nalls, M A, Nelson, C P, Sotoodehnia, N, Norris, J M, O'connell, J R, Palmer, N D, Perls, T, Pedersen, N L, Peters, A, Peyser, P A, Poulter, N, Raffel, L J, Raitakari, O T, Roll, K, Rose, L M, Rosendaal, F R, Rotter, J I, Schmidt, C O, Schreiner, P J, Schupf, N, Scott, W R, Sever, P S, Shi, Y, Sidney, S, Sims, M, Sitlani, C M, Smith, J A, Snieder, H, Starr, J M, Strauch, K, Stringham, H M, Tan, N Y Q, Tang, H, Taylor, K D, Teo, Y Y, Tham, Y C, Turner, S T, Uitterlinden, A G, Vollenweider, P, Waldenberger, M, Wang, L, Wang, Y X, Wei, W B, Williams, C, Yao, J, Yu, C, Yuan, J, Zhao, W, Zonderman, A B, Becker, D M, Boehnke, M, Bowden, D W, Chambers, J C, Deary, I J, Esko, T, Farrall, M, Franks, P W, Freedman, B I, Froguel, P, Gasparini, P, Gieger, C, Jonas, J B, Kamatani, Y, Kato, N, Kooner, J S, Kutalik, Z, Laakso, M, Laurie, C C, Leander, K, Lehtimäki, T, Study, L C, Magnusson, P K E, Oldehinkel, A J, Penninx, B W J H, Polasek, O, Porteous, D J, Rauramaa, R, Samani, N J, Scott, J, Shu, X, Van Der Harst, P, Wagenknecht, L E, Wareham, N J, Watkins, H, Weir, D R, Wickremasinghe, A R, Wu, T, Zheng, W, Bouchard, C, Christensen, K, Evans, M K, Gudnason, V, Horta, B L, Kardia, S L R, Liu, Y, Pereira, A C, Psaty, B M, Ridker, P M, Van Dam, R M, Gauderman, W J, Zhu, X, Mook-kanamori, D O, Fornage, M, Rotimi, C N, Cupples, L A, Kelly, T N, Fox, E R, Hayward, C, Van Duijn, C M, Tai, E S, Wong, T Y, Kooperberg, C, Palmas, W, Rice, K, Morrison, A C, Elliott, P, Caulfield, M J, Munroe, P B, Rao, D C, Province, M A, Levy, D & Kuivaniemi, H 2018, ' Novel genetic associations for blood pressure identified via gene-alcohol interaction in up to 570K individuals across multiple ancestries ', PLoS ONE, vol. 13, no. 6, pp. e0198166 . https://doi.org/10.1371/journal.pone.0198166
PLoS One (online), 13(6):e0198166. Public Library of Science
PLoS ONE, 13(6):0198166. PUBLIC LIBRARY SCIENCE
PLoS ONE
PLoS ONE, Public Library of Science, 2018, 13 (6), pp.e0198166. ⟨10.1371/journal.pone.0198166⟩
PloS one, vol. 13, no. 6, pp. e0198166
PLoS ONE, Vol 13, Iss 6, p e0198166 (2018)
InterAct Consortium 2018, ' Novel genetic associations for blood pressure identified via gene-alcohol interaction in up to 570K individuals across multiple ancestries ', PLOS ONE, vol. 13, no. 6, e0198166 . https://doi.org/10.1371/journal.pone.0198166
PLOS ONE
PLoS ONE 13:e0198166 (2018)
Feitosa, M F & Levy, D 2018, ' Novel genetic associations for blood pressure identified via gene-alcohol interaction in up to 570K individuals across multiple ancestries ', PLoS ONE, vol. 13, no. 6, e0198166 . https://doi.org/10.1371/journal.pone.0198166
PLoS ONE, 2018, 13 (6), pp.e0198166. ⟨10.1371/journal.pone.0198166⟩
PLoS ONE, 13(6)
Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual)
Universidade de São Paulo (USP)
instacron:USP
PLoS ONE, 13(6):e0198166. Public Library of Science
PLOS ONE, Vol. 13, No 6 (2018) P. e0198166

Publisher's version (útgefin grein).
Heavy alcohol consumption is an established risk factor for hypertension; the mechanism by which alcohol consumption impact blood pressure (BP) regulation remains unknown. We hypothesized that a genome-wide

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::766b707c74cf4663079aeb5681d2aef7
https://curis.ku.dk/portal/da/publications/novel-genetic-associations-for-blood-pressure-identified-via-genealcohol-interaction-in-up-to-570k-individuals-across-multiple-ancestries(bab90887-86d2-4a0e-810d-0e7f854caeb2).html

New genetic loci link adipose and insulin biology to body fat distribution

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Publikováno v: Nature, vol. 518, no. 7538, pp. 187-196
Nature
Nature, 2015, 518 (7538), pp.187-96. ⟨10.1038/nature14132⟩
Nature 518(7538), 187-196 (2015). doi:10.1038/nature14132
Nature, 518(7538), 187-U378. Nature Publishing Group
Nature, Nature Publishing Group, 2015, 518 (7538), pp.187-96. ⟨10.1038/nature14132⟩
Nature, 518(7538), 187-196. Nature Publishing Group
Nature, 518(7538), 187. Nature Publishing Group
Nature, 518(7538), 187-U378
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Nature, Nature Publishing Group, 2015, 518 (7538), pp.187-96. 〈10.1038/nature14132〉
Repositorio Institucional de la Consejería de Sanidad de la Comunidad de Madrid
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Body fat distribution is a heritable trait and a well-established predictor of adverse metabolic outcomes, independent of overall adiposity. To increase our understanding of the genetic basis of body fat distribution and its molecular links to cardio

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