Zobrazeno 1 - 5
of 5
pro vyhledávání: '"Poppy A Gould"'
Autor:
Rocio Enriquez-Gasca, Poppy A. Gould, Hale Tunbak, Lucia Conde, Javier Herrero, Alexandra Chittka, Christine R. Beck, Robert Gifford, Helen M. Rowe
Publikováno v:
Cell Reports, Vol 42, Iss 6, Pp 112625- (2023)
Summary: Endogenous retroviruses (ERVs) have rewired host gene networks. To explore the origins of co-option, we employed an active murine ERV, IAPEz, and an embryonic stem cell (ESC) to neural progenitor cell (NPC) differentiation model. Transcripti
Externí odkaz:
https://doaj.org/article/6a9e0395bbad4b8485afd09c5158792b
Autor:
Hale Tunbak, Rocio Enriquez-Gasca, Christopher H. C. Tie, Poppy A. Gould, Petra Mlcochova, Ravindra K. Gupta, Liane Fernandes, James Holt, Annemarthe G. van der Veen, Evangelos Giampazolias, Kathleen H. Burns, Pierre V. Maillard, Helen M. Rowe
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-15 (2020)
The HUSH complex has been implicated in repressing LINE-1 elements. Here the authors reveal that the complex negatively regulates the type I IFN response in human cells through epigenetic regulation of LINE-1 elements
Externí odkaz:
https://doaj.org/article/ee339e70658d4865897566aa7c7f8a90
Publikováno v:
Viruses, Vol 12, Iss 10, p 1089 (2020)
The human genome has been under selective pressure to evolve in response to emerging pathogens and other environmental challenges. Genome evolution includes the acquisition of new genes or new isoforms of genes and changes to gene expression patterns
Externí odkaz:
https://doaj.org/article/ebe0d53d73cc46f5b3189ef487e7a9b4
Autor:
Liane Fernandes, Annemarthe G. van der Veen, Petra Mlcochova, Christopher H.C. Tie, Ravindra K. Gupta, Helen M. Rowe, Rocio Enriquez-Gasca, James Holt, Kathleen H. Burns, Hale Tunbak, Poppy A Gould, Pierre V. Maillard, Evangelos Giampazolias
Publikováno v:
Nature Communications
Nature Communications, Vol 11, Iss 1, Pp 1-15 (2020)
Nature Communications, 11(1). NATURE PORTFOLIO
Nature Communications, Vol 11, Iss 1, Pp 1-15 (2020)
Nature Communications, 11(1). NATURE PORTFOLIO
Funder: UKRI Future Leaders Fellowship (MR/S034498/1)
The Human Silencing Hub (HUSH) complex is necessary for epigenetic repression of LINE-1 elements. We show that HUSH-depletion in human cell lines and primary fibroblasts leads to induction of
The Human Silencing Hub (HUSH) complex is necessary for epigenetic repression of LINE-1 elements. We show that HUSH-depletion in human cell lines and primary fibroblasts leads to induction of
Autor:
Helen M. Rowe, Poppy A Gould
Publikováno v:
EMBO Rep
Understanding of the appropriate regulation of enzymatic activities of histone‐modifying enzymes remains poor. The lysine methyltransferase, SETDB1, is one of the enzymes responsible for the methylation of histone H3 at lysine 9 (H3K9) and plays a