Human embryoid bodies as a novel system for genomic studies of functionally diverse cell types

Autor: Yoav Gilad, Kenneth Barr, Benjamin J. Strober, Popp Jm, Alexis Battle, Katherine Rhodes

Publikováno v: eLife, Vol 11 (2022)

Practically all studies of gene expression in humans to date have been performed in a relatively small number of adult tissues. Gene regulation is highly dynamic and context-dependent. In order to better understand the connection between gene regulat

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fa78476eeb4dec297773625113c1dfe2
https://doi.org/10.1101/2021.06.16.448714

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Single-cell allele-specific expression analysis reveals dynamic and cell-type-specific regulatory effects.

Autor: Qi G; Department of Biomedical Engineering, Johns Hopkins University, Baltimore, MD, 21218, USA.; Department of Biostatistics, University of Washington, Seattle, WA, 98195, USA., Strober BJ; Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA, 02115, USA., Popp JM; Department of Biomedical Engineering, Johns Hopkins University, Baltimore, MD, 21218, USA., Keener R; Department of Biomedical Engineering, Johns Hopkins University, Baltimore, MD, 21218, USA., Ji H; Department of Biostatistics, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, 21205, USA., Battle A; Department of Biomedical Engineering, Johns Hopkins University, Baltimore, MD, 21218, USA. ajbattle@jhu.edu.; Department of Computer Science, Johns Hopkins University, Baltimore, MD, 21218, USA. ajbattle@jhu.edu.; Department of Genetic Medicine, Johns Hopkins University, Baltimore, MD, 21205, USA. ajbattle@jhu.edu.

Publikováno v: Nature communications [Nat Commun] 2023 Oct 09; Vol. 14 (1), pp. 6317. Date of Electronic Publication: 2023 Oct 09.

Single-cell sequencing reveals lineage-specific dynamic genetic regulation of gene expression during human cardiomyocyte differentiation.

Autor: Elorbany R; Interdisciplinary Scientist Training Program, University of Chicago, Chicago, Illinois, United States of America., Popp JM; Department of Biomedical Engineering, Johns Hopkins University, Baltimore, Maryland, United States of America., Rhodes K; Department of Human Genetics, University of Chicago, Chicago, Illinois, United States of America., Strober BJ; Department of Biomedical Engineering, Johns Hopkins University, Baltimore, Maryland, United States of America., Barr K; Department of Human Genetics, University of Chicago, Chicago, Illinois, United States of America., Qi G; Department of Biomedical Engineering, Johns Hopkins University, Baltimore, Maryland, United States of America., Gilad Y; Department of Human Genetics, University of Chicago, Chicago, Illinois, United States of America.; Department of Medicine, University of Chicago, Chicago, Illinois, United States of America., Battle A; Department of Biomedical Engineering, Johns Hopkins University, Baltimore, Maryland, United States of America.; Department of Computer Science, Johns Hopkins University, Baltimore, Maryland, United States of America.; Department of Genetic Medicine, Johns Hopkins University, Baltimore, Maryland, United States of America.

Publikováno v: PLoS genetics [PLoS Genet] 2022 Jan 21; Vol. 18 (1), pp. e1009666. Date of Electronic Publication: 2022 Jan 21 (Print Publication: 2022).