Safety and Efficacy of Ceftolozane/Tazobactam Versus Meropenem in Neonates and Children With Complicated Urinary Tract Infection, Including Pyelonephritis: A Phase 2, Randomized Clinical Trial.

Autor: Roilides E; From the Third Department of Pediatrics, Infectious Diseases Unit, School of Medicine, Aristotle University and Hippokration General Hospital, Thessaloniki, Greece., Ashouri N; Division of Infectious Diseases, CHOC Children's Hospital, Orange, California., Bradley JS; Department of Pediatrics, University of California San Diego School of Medicine and Rady Children's Hospital of San Diego, San Diego, California., Johnson MG; Merck & Co., Inc., Rahway, New Jersey., Lonchar J; Merck & Co., Inc., Rahway, New Jersey., Su FH; Merck & Co., Inc., Rahway, New Jersey., Huntington JA; Merck & Co., Inc., Rahway, New Jersey., Popejoy MW; Merck & Co., Inc., Rahway, New Jersey., Bensaci M; Merck & Co., Inc., Rahway, New Jersey., De Anda C; Merck & Co., Inc., Rahway, New Jersey., Rhee EG; Merck & Co., Inc., Rahway, New Jersey., Bruno CJ; Merck & Co., Inc., Rahway, New Jersey.

Publikováno v: The Pediatric infectious disease journal [Pediatr Infect Dis J] 2023 Apr 01; Vol. 42 (4), pp. 292-298. Date of Electronic Publication: 2023 Jan 23.

A Phase 3, Randomized, Double-Blind Study Comparing Tedizolid Phosphate and Linezolid for Treatment of Ventilated Gram-Positive Hospital-Acquired or Ventilator-Associated Bacterial Pneumonia.

Autor: Wunderink RG; Department of Medicine, Division of Pulmonary and Critical Care, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA., Roquilly A; Université de Nantes, Centre Hospitalier Universitaire de Nantes, EA3826 Thérapeutiques Anti-Infectieuses, Service d'Anesthésie Réanimation Chirurgicale, Hôtel Dieu, Nantes, F-44000., Croce M; Regional One Health, Memphis, Tennessee, USA., Rodriguez Gonzalez D; Department of Intensive Care, Nuevo Hospital Civil de Guadalajara, Guadalajara, Jalisco, Mexico., Fujimi S; Department of Trauma, Critical Care, and Emergency Medicine, Osaka General Medical Center, Sumiyoshi-ku, Osaka, Japan., Butterton JR; Merck Research Laboratories, Merck & Co, Inc, Kenilworth, New Jersey, USA., Broyde N; Merck Research Laboratories, Merck & Co, Inc, Kenilworth, New Jersey, USA., Popejoy MW; Merck Research Laboratories, Merck & Co, Inc, Kenilworth, New Jersey, USA., Kim JY; Merck Research Laboratories, Merck & Co, Inc, Kenilworth, New Jersey, USA., De Anda C; Merck Research Laboratories, Merck & Co, Inc, Kenilworth, New Jersey, USA.

Publikováno v: Clinical infectious diseases : an official publication of the Infectious Diseases Society of America [Clin Infect Dis] 2021 Aug 02; Vol. 73 (3), pp. e710-e718.

Randomized Multicenter Study Comparing Safety and Efficacy of Daptomycin Versus Standard-of-care in Pediatric Patients With Staphylococcal Bacteremia.

Autor: Arrieta AC; From the Pediatric Infectious Disease, Children's Hospital of Orange County, Orange, California., Bradley JS; Division of Infectious Diseases, Rady Children's Hospital, San Diego, California., Popejoy MW; Merck Research Laboratories, Merck & Co., Inc., Kenilworth, New Jersey., Bensaci M; Merck Research Laboratories, Merck & Co., Inc., Kenilworth, New Jersey., Grandhi A; Merck Research Laboratories, Merck & Co., Inc., Kenilworth, New Jersey., Bokesch P; Merck Research Laboratories, Merck & Co., Inc., Kenilworth, New Jersey., Glasser C; Merck Research Laboratories, Merck & Co., Inc., Kenilworth, New Jersey., Du L; Merck Research Laboratories, Merck & Co., Inc., Kenilworth, New Jersey., Patino H; Merck Research Laboratories, Merck & Co., Inc., Kenilworth, New Jersey., Kartsonis NA; Merck Research Laboratories, Merck & Co., Inc., Kenilworth, New Jersey.

Publikováno v: The Pediatric infectious disease journal [Pediatr Infect Dis J] 2018 Sep; Vol. 37 (9), pp. 893-900.

Does moderate renal impairment affect clinical outcomes in complicated intra-abdominal and complicated urinary tract infections? Analysis of two randomized controlled trials with ceftolozane/tazobactam.

Autor: Kullar R; Merck Research Laboratories, Merck & Co, Inc., 2000 Galloping Hill Road, Kenilworth, NJ 07033, USA., Wagenlehner FM; Department of Urology, Pediatric Urology and Andrology, Justus Liebig University Gießen, Rudolf-Buchheim Str. 7, 35392 Gießen, Germany., Popejoy MW; Merck Research Laboratories, Merck & Co, Inc., 2000 Galloping Hill Road, Kenilworth, NJ 07033, USA., Long J; Merck Research Laboratories, Merck & Co, Inc., 2000 Galloping Hill Road, Kenilworth, NJ 07033, USA., Yu B; Merck Research Laboratories, Merck & Co, Inc., 2000 Galloping Hill Road, Kenilworth, NJ 07033, USA., Goldstein EJ; David Geffen School of Medicine, University of California Los Angeles, 10833 Le Conte Ave, Los Angeles, CA 90095, USA.; R. M. Alden Research Laboratory, 6133 Bristol Pkway #175, Santa Monica, CA 90230, USA.

Publikováno v: The Journal of antimicrobial chemotherapy [J Antimicrob Chemother] 2017 Mar 01; Vol. 72 (3), pp. 900-905.

Efficacy of ceftolozane/tazobactam against urinary tract and intra-abdominal infections caused by ESBL-producing Escherichia coli and Klebsiella pneumoniae: a pooled analysis of Phase 3 clinical trials.

Autor: Popejoy MW; Merck & Co., Inc., Kenilworth, NJ, USA myra.popejoy@merck.com., Paterson DL; Center for Clinical Research, University of Queensland, Brisbane, Australia., Cloutier D; Merck & Co., Inc., Kenilworth, NJ, USA., Huntington JA; Merck & Co., Inc., Kenilworth, NJ, USA., Miller B; Merck & Co., Inc., Kenilworth, NJ, USA., Bliss CA; Merck & Co., Inc., Kenilworth, NJ, USA., Steenbergen JN; Merck & Co., Inc., Kenilworth, NJ, USA., Hershberger E; Merck & Co., Inc., Kenilworth, NJ, USA., Umeh O; Merck & Co., Inc., Kenilworth, NJ, USA., Kaye KS; Detroit Medical Center and Department of Medicine, Wayne State University, Detroit, MI, USA.

Publikováno v: The Journal of antimicrobial chemotherapy [J Antimicrob Chemother] 2017 Jan; Vol. 72 (1), pp. 268-272. Date of Electronic Publication: 2016 Oct 05.