Perturbation biology: inferring signaling networks in cellular systems.

Autor: Evan J Molinelli, Anil Korkut, Weiqing Wang, Martin L Miller, Nicholas P Gauthier, Xiaohong Jing, Poorvi Kaushik, Qin He, Gordon Mills, David B Solit, Christine A Pratilas, Martin Weigt, Alfredo Braunstein, Andrea Pagnani, Riccardo Zecchina, Chris Sander

Publikováno v: PLoS Computational Biology, Vol 9, Iss 12, p e1003290 (2013)

We present a powerful experimental-computational technology for inferring network models that predict the response of cells to perturbations, and that may be useful in the design of combinatorial therapy against cancer. The experiments are systematic

Externí odkaz: https://doaj.org/article/b42abf9d37ee45299b42ecb7866bb94f

Spatial normalization of reverse phase protein array data

Autor: Evan J Molinelli, Yiling Lu, Gordon B. Mills, Weiqing Wang, Wenbin Liu, Zhenlin Ju, Poorvi Kaushik, Chris Sander, Anil Korkut, Martin L. Miller

Publikováno v: PLoS ONE, Vol 9, Iss 12, p e97213 (2014)
PLoS ONE

Reverse phase protein arrays (RPPA) are an efficient, high-throughput, cost-effective method for the quantification of specific proteins in complex biological samples. The quality of RPPA data may be affected by various sources of error. One of these

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::01f108dccf421d0fba9829036076e3b1

Integrative Genomic Profiling of Human Prostate Cancer

Autor: Yonghong Xiao, Yevgeniy Antipin, Charles L. Sawyers, Anuradha Gopalan, Igor Dolgalev, John E. Major, Chris Sander, Nikolaus Schultz, William L. Gerald, Poorvi Kaushik, Victor E. Reuter, Nicholas Mitsiades, Howard I. Scher, Nicholas D. Socci, Alex E. Lash, Thomas Landers, Peter T. Scardino, Vivek K. Arora, Adriana Heguy, Ethan Cerami, Barry S. Taylor, Brett S. Carver, Haley Hieronymus, Manda Wilson, Boris Reva, James A. Eastham

Publikováno v: Cancer Cell. 18:11-22

Annotation of prostate cancer genomes provides a foundation for discoveries that can impact disease understanding and treatment. Concordant assessment of DNA copy number, mRNA expression, and focused exon resequencing in 218 prostate cancer tumors id

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::44b1d0860133994745311386dd7792b1
https://doi.org/10.1016/j.ccr.2010.05.026

Perturbation Biology: inferring signaling networks in cellular systems

Autor: Riccardo Zecchina, Gordon B. Mills, Andrea Pagnani, Xiaohong Jing, David B. Solit, Alfredo Braunstein, Nicholas P. Gauthier, Qin He, Poorvi Kaushik, Chris Sander, Anil Korkut, Christine A. Pratilas, Martin Weigt, Martin L. Miller, Weiqing Wang, Evan J Molinelli

Publikováno v: PLoS Computational Biology
PLoS Computational Biology, 2013, 9 (12), pp.e1003290. ⟨10.1371/journal.pcbi.1003290⟩
PLoS Computational Biology, Public Library of Science, 2013, 9 (12), pp.e1003290. ⟨10.1371/journal.pcbi.1003290⟩
PLoS Computational Biology, Vol 9, Iss 12, p e1003290 (2013)

We present a powerful experimental-computational technology for inferring network models that predict the response of cells to perturbations, and that may be useful in the design of combinatorial therapy against cancer. The experiments are systematic

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7cd849c1d5bd8255e0e35ee2b7ff01e0
http://arxiv.org/abs/1308.5193

Abstract A24: Network models of signaling and drug response in melanoma

Autor: Chris Sander, Nick Gauthier, Poorvi Kaushik, Xiaohong Jing, Martin Miller, Weiqing Wang, Arman Aksoy, Evan J Molinelli, Anil Korkut

Publikováno v: Molecular Cancer Therapeutics. 12:A24-A24

Novel combination therapies are potentially key to preventing emergence of resistance to initially successful single agent therapies such as RAF inhibitors in melanoma. In order to systematically nominate novel and effective drug combinations, we hav

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::f612ba0d38cdbc8bd0d7d6027fed39d8
https://doi.org/10.1158/1535-7163.targ-13-a24