Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Poorval Joshi"'
Autor:
Giulia Biancon, Emma Busarello, Poorval Joshi, Bluma J. Lesch, Stephanie Halene, Toma Tebaldi
Publikováno v:
STAR Protocols, Vol 3, Iss 4, Pp 101823- (2022)
Summary: Thousands of RNA-binding proteins orchestrate RNA processing and altered protein-RNA interactions frequently lead to disease. Here, we present experimental and computational analysis pipelines of fractionated eCLIP-seq (freCLIP-seq), a modif
Externí odkaz:
https://doaj.org/article/56bb40d7be52447cafee6d5ba7f682c0
Autor:
Giulia Biancon, Poorval Joshi, Joshua T. Zimmer, Torben Hunck, Yimeng Gao, Mark D. Lessard, Edward Courchaine, Andrew E.S. Barentine, Martin Machyna, Valentina Botti, Ashley Qin, Rana Gbyli, Amisha Patel, Yuanbin Song, Lea Kiefer, Gabriella Viero, Nils Neuenkirchen, Haifan Lin, Joerg Bewersdorf, Matthew D. Simon, Karla M. Neugebauer, Toma Tebaldi, Stephanie Halene
Publikováno v:
Mol Cell
Splicing factor mutations are common among cancers, recently emerging as drivers of myeloid malignancies. U2AF1 carries hotspot mutations in its RNA-binding motifs; however, how they affect splicing and promote cancer remain unclear. The U2AF1/U2AF2
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a9732eb1548edc00558760338c886ade
https://europepmc.org/articles/PMC8988922/
https://europepmc.org/articles/PMC8988922/
Autor:
Toma Tebaldi, Mark D. Lessard, Joshua T. Zimmer, Gabriella Viero, Poorval Joshi, Valentina Botti, Ashley Qin, Karla M. Neugebauer, Giulia Biancon, Torben Hunck, Rana Gbyli, Lea Kiefer, Andrew Es Barentine, Joerg Bewersdorf, Edward M. Courchaine, Yuanbin Song, Matthew D. Simon, Nils Neuenkirchen, Stephanie Halene, Martin Machyna, Haifan Lin, Amisha Patel, Yimeng Gao
Somatic mutations in splicing factors are of significant interest in myeloid malignancies and other cancers. U2AF1, together with U2AF2, is essential for 3’ splice site recognition. U2AF1 mutations result in aberrant splicing, but the molecular mec
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ee3ecf3e301da6963e53d2e34aaabe26
https://doi.org/10.1101/2021.04.22.441020
https://doi.org/10.1101/2021.04.22.441020
Autor:
Giulia Biancon, Poorval Joshi, Joshua T Zimmer, Torben Hunck, Yimeng Gao, Mark D Lessard, Edward Courchaine, Andrew ES Barentine, Martin Machyna, Valentina Botti, Ashley Qin, Rana Gbyli, Amisha Patel, Yuanbin Song, Lea Kiefer, Gabriella Viero, Nils Neuenkirchen, Haifan Lin, Joerg Bewersdorf, Matthew D Simon, Karla M Neugebauer, Toma Tebaldi, Stephanie Halene
Publikováno v:
Blood. 138:321-321
Somatic mutations in splicing factor genes are drivers of myelodysplastic syndromes (MDS) and acute myeloid leukemia (AML). The splicing factors U2AF1 and U2AF2 form the U2AF heterodimer that is critical in the 3' splice site (3'SS) recognition and i
Autor:
Torben Hunck, Giulia Biancon, Rana Gbyli, Toma Tebaldi, Anastasia Ardasheva, Nils Neuenkirchen, Xiaoying Fu, Haifan Lin, Valentina Botti, Karla M. Neugebauer, Josh Zimmer, Matthew D. Simon, Amisha Patel, Martin Machyna, Gabriella Viero, Poorval Joshi, Stephanie Halene, Yimeng Gao, Ashley Taylor, Ashley Qin
Publikováno v:
Blood. 136:3-4
Spliceosomal gene mutations function as drivers of hematologic malignancies and other cancers with an occurrence of more than 50% in myelodysplastic syndromes and secondary acute myeloid leukemia. Hotspot mutations S34F and Q157R in the two zinc fing
Autor:
Yimeng, Gao, Radovan, Vasic, Yuanbin, Song, Rhea, Teng, Chengyang, Liu, Rana, Gbyli, Giulia, Biancon, Raman, Nelakanti, Kirsten, Lobben, Eriko, Kudo, Wei, Liu, Anastasia, Ardasheva, Xiaoying, Fu, Xiaman, Wang, Poorval, Joshi, Veronica, Lee, Burak, Dura, Gabriella, Viero, Akiko, Iwasaki, Rong, Fan, Andrew, Xiao, Richard A, Flavell, Hua-Bing, Li, Toma, Tebaldi, Stephanie, Halene
Publikováno v:
Immunity
N(6) methyladenosine (m(6)A) is the most abundant RNA modification, but little is known about its role in mammalian hematopoietic development. Here, we show that conditional deletion of the m(6)A writer METTL3 in murine fetal liver resulted in hemato
Mutations in RNA splicing factors are the single most common class of genetic alterations in myelodysplastic syndrome (MDS) patients. Although much has been learned about how these mutations affect splicing at a global- and transcript-specific level,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::57e8f8638084fa20fcddc0147a89ad5b
https://europepmc.org/articles/PMC5418633/
https://europepmc.org/articles/PMC5418633/
Autor:
Kai Rejeski, Radovan Vasic, Poorval Joshi, Anastasia Ardasheva, Stephanie Halene, Kunthavai Balasubramanian, Yuanbin Song, Yang Liang, Alessandro Quattrone, Giovanni Stefani, Ashley Taylor, Jamie Maziarz, Alicia Ding, Toma Tebaldi
Publikováno v:
Leukemia
Recurrent mutations in the splicing factor SRSF2 are associated with poor clinical outcomes in myelodysplastic syndromes (MDS). Their high frequency suggests these mutations drive oncogenesis, yet the molecular explanation for this process is unclear
Our laboratory was one of the first to engineer a live fluorescent tag, enhanced green fluorescent protein (eGFP), that marked the capsid of herpes simplex virus type 1 (HSV-1) and subsequently maturing virus as the particle made its way to the cell
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::973b9f5e46d3fe86c17af839dd156b26
https://europepmc.org/articles/PMC5661875/
https://europepmc.org/articles/PMC5661875/
Autor:
Valentina Botti, Toma Tebaldi, Ashley Qin, Giulia Biancon, Anastasia Ardasheva, Stephanie Halene, Clara L. Kielkopf, Ashley Taylor, Xiaoying Fu, Karla M. Neugebauer, Gabriella Viero, Manoj M. Pillai, Mukhtar Sadykov, Poorval Joshi, Yimeng Gao, Nils Neuenkirchen, Xiaman Wang, Torben Hunck, Haifan Lin, Jane Huang
Publikováno v:
Blood. 134:1230-1230
Among genetic aberrations responsible for ineffective hematopoiesis in myelodysplastic syndromes (MDS) and acute myeloid leukemia, somatic mutations in splicing factors such as U2AF1 are of significant interest as they are recurrent, mutually exclusi