Zobrazeno 1 - 10 of 1 014 pro vyhledávání: '"Poortinga, G."'
1
Akademický článek
CX-5461 Preferentially Induces Top2α-Dependent DNA Breaks at Ribosomal DNA Loci.
Autor: Cameron DP; ACRF Department of Cancer Biology and Therapeutics, Division of Genome Sciences and Cancer, The John Curtin School of Medical Research, The College of Health and Medicine, The Australian National University, Canberra, ACT 2601, Australia.; Division of Cancer Research, Peter MacCallum Cancer Centre, Melbourne, VIC 3000, Australia., Sornkom J; Division of Cancer Research, Peter MacCallum Cancer Centre, Melbourne, VIC 3000, Australia.; Sir Peter MacCallum Department of Oncology, University of Melbourne, Melbourne, VIC 3000, Australia., Alsahafi S; School of Biological Sciences, Queen's University Belfast, Belfast BT9 5DL, UK., Drygin D; Pimera Therapeutics, 7875 Highland Village Place, Suite 412, San Diego, CA 92129, USA., Poortinga G; Division of Cancer Research, Peter MacCallum Cancer Centre, Melbourne, VIC 3000, Australia., McArthur GA; Sir Peter MacCallum Department of Oncology, University of Melbourne, Melbourne, VIC 3000, Australia., Hein N; ACRF Department of Cancer Biology and Therapeutics, Division of Genome Sciences and Cancer, The John Curtin School of Medical Research, The College of Health and Medicine, The Australian National University, Canberra, ACT 2601, Australia., Hannan R; ACRF Department of Cancer Biology and Therapeutics, Division of Genome Sciences and Cancer, The John Curtin School of Medical Research, The College of Health and Medicine, The Australian National University, Canberra, ACT 2601, Australia.; Division of Cancer Research, Peter MacCallum Cancer Centre, Melbourne, VIC 3000, Australia.; Department of Biochemistry and Molecular Biology, University of Melbourne, Parkville, VIC 3053, Australia.; Department of Biochemistry and Molecular Biology, Monash University, Clayton, VIC 3800, Australia.; School of Biomedical Sciences, University of Queensland, St Lucia, QLD 4072, Australia., Panov KI; School of Biological Sciences, Queen's University Belfast, Belfast BT9 5DL, UK.; Patrick G Johnston Centre for Cancer Research, Queen's University Belfast, Belfast BT9 7AE, UK.
Publikováno v: Biomedicines [Biomedicines] 2024 Jul 08; Vol. 12 (7). Date of Electronic Publication: 2024 Jul 08.
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2
Akademický článek
Targeting the ribosome to treat multiple myeloma.
Autor: Maclachlan KH; Cancer Research Division, Peter MacCallum Cancer Centre, Melbourne, VIC, Australia.; Sir Peter MacCallum Department of Oncology, University of Melbourne, Melbourne, VIC, Australia.; Clinical Hematology, Peter MacCallum Cancer Centre, Melbourne, VIC, Australia., Gitareja K; St Vincent's Institute of Medical Research, Melbourne, VIC, Australia.; Department of Medicine- St Vincent's Hospital, University of Melbourne, Melbourne, VIC, Australia., Kang J; St Vincent's Institute of Medical Research, Melbourne, VIC, Australia.; Department of Medicine- St Vincent's Hospital, University of Melbourne, Melbourne, VIC, Australia., Cuddihy A; Cancer Research Division, Peter MacCallum Cancer Centre, Melbourne, VIC, Australia., Cao Y; Cancer Research Division, Peter MacCallum Cancer Centre, Melbourne, VIC, Australia.; Sir Peter MacCallum Department of Oncology, University of Melbourne, Melbourne, VIC, Australia.; Clinical Hematology, Peter MacCallum Cancer Centre, Melbourne, VIC, Australia., Hein N; The ACRF Department of Cancer Biology and Therapeutics, The John Curtin School of Medical Research, Australian National University, Canberra, ACT, Australia., Cullinane C; Cancer Research Division, Peter MacCallum Cancer Centre, Melbourne, VIC, Australia., Ang CS; The Bio21 Institute of Molecular Science and Biotechnology Institute, University of Melbourne, Melbourne, VIC, Australia., Brajanovski N; Cancer Research Division, Peter MacCallum Cancer Centre, Melbourne, VIC, Australia., Pearson RB; Cancer Research Division, Peter MacCallum Cancer Centre, Melbourne, VIC, Australia.; Sir Peter MacCallum Department of Oncology, University of Melbourne, Melbourne, VIC, Australia.; Department of Biochemistry and Molecular Biology, Monash University, Melbourne, VIC, Australia., Khot A; Sir Peter MacCallum Department of Oncology, University of Melbourne, Melbourne, VIC, Australia.; Clinical Hematology, Peter MacCallum Cancer Centre, Melbourne, VIC, Australia., Sanij E; Cancer Research Division, Peter MacCallum Cancer Centre, Melbourne, VIC, Australia.; Sir Peter MacCallum Department of Oncology, University of Melbourne, Melbourne, VIC, Australia.; St Vincent's Institute of Medical Research, Melbourne, VIC, Australia.; Department of Medicine- St Vincent's Hospital, University of Melbourne, Melbourne, VIC, Australia.; Department of Biochemistry and Molecular Biology, Monash University, Melbourne, VIC, Australia., Hannan RD; The ACRF Department of Cancer Biology and Therapeutics, The John Curtin School of Medical Research, Australian National University, Canberra, ACT, Australia.; Department of Biochemistry and Molecular Biology, Monash University, Melbourne, VIC, Australia., Poortinga G; Cancer Research Division, Peter MacCallum Cancer Centre, Melbourne, VIC, Australia.; Sir Peter MacCallum Department of Oncology, University of Melbourne, Melbourne, VIC, Australia., Harrison SJ; Cancer Research Division, Peter MacCallum Cancer Centre, Melbourne, VIC, Australia.; Sir Peter MacCallum Department of Oncology, University of Melbourne, Melbourne, VIC, Australia.; Clinical Hematology, Peter MacCallum Cancer Centre, Melbourne, VIC, Australia.
Publikováno v: Molecular therapy. Oncology [Mol Ther Oncol] 2024 Feb 07; Vol. 32 (1), pp. 200771. Date of Electronic Publication: 2024 Feb 07 (Print Publication: 2024).
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3
Akademický článek
Targeting RNA polymerase I to treat MYC-driven cancer.
Autor: Poortinga, G1, Quinn, L M2, Hannan, R D3
Publikováno v: Oncogene. 1/22/2015, Vol. 34 Issue 4, p403-412. 10p. 3 Diagrams, 1 Chart.
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4
Reprogrammed mRNA translation drives metabolic response to therapeutic targeting of ribosome biogenesis
Autor: Kusnadi, E. P., Trigos, A. S., Cullinane, C., Goode, D. L., Larsson, O., Devlin, J. R., Chan, K. T., De Souza, D. P., McConville, M. J., McArthur, G. A., Thomas, G., Sanij, E., Poortinga, G., Hannan, R. D., Hannan, K. M., Kang, J., Pearson, R. B.
Elevated ribosome biogenesis in oncogene-driven cancers is commonly targeted by DNA-damaging cytotoxic drugs. Our first-in-human trial of CX-5461, a novel, less genotoxic agent that specifically inhibits ribosome biogenesis via suppression of RNA Pol
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=sharebioRxiv::c4627638ea534f337b36f1b9eca00164
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5
Akademický článek
Modeling the consequences of age-linked rDNA hypermethylation with dCas9-directed DNA methylation in human cells.
Autor: Blokhina, Yana1 (AUTHOR), Buchwalter, Abigail1 (AUTHOR) abigail.buchwalter@ucsf.edu
Publikováno v: PLoS ONE. 12/12/2024, Vol. 19 Issue 12, p1-20. 20p.
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6
Akademický článek
The Interplay Between the MYC Oncogene and Ribosomal Proteins in Osteosarcoma Onset and Progression: Potential Mechanisms and Indication of Candidate Therapeutic Targets.
Autor: Guerrieri, Ania Naila1 (AUTHOR) anianaila.guerrieri@ior.it, Hattinger, Claudia Maria1 (AUTHOR) claudia.hattinger@ior.it, Marchesini, Federica2 (AUTHOR) federica.marchesini9@unibo.it, Melloni, Martina2 (AUTHOR) martina.melloni6@studio.unibo.it, Serra, Massimo1 (AUTHOR) toni.ibrahim@ior.it, Ibrahim, Toni1 (AUTHOR), Penzo, Marianna2,3 (AUTHOR) claudia.hattinger@ior.it
Publikováno v: International Journal of Molecular Sciences. Nov2024, Vol. 25 Issue 22, p12031. 22p.
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7
Akademický článek
Oral administration of Sophora Flavescens-derived exosomes-like nanovesicles carrying CX5461 ameliorates DSS-induced colitis in mice.
Autor: Zhang, Manqi1 (AUTHOR), Xu, Xichao2,3 (AUTHOR), Su, Liqian2,4 (AUTHOR), Zeng, Yuqing1 (AUTHOR), Lin, Jingxiong1 (AUTHOR), Li, Wenwen2 (AUTHOR), Zou, Yigui2 (AUTHOR), Li, Sicong2 (AUTHOR), Lin, Boxian2 (AUTHOR), Li, Ziyuan2 (AUTHOR), Chen, Hu2 (AUTHOR), Huang, Yuheng1 (AUTHOR), Xu, Quanle4 (AUTHOR), Chen, Hongbo1 (AUTHOR) chenhb7@mail.sysu.edu.cn, Cheng, Fang1 (AUTHOR) chengf9@mail.sysu.edu.cn, Dai, Dongling2 (AUTHOR) daidong3529@sina.com
Publikováno v: Journal of Nanobiotechnology. 10/8/2024, Vol. 22 Issue 1, p1-17. 17p.
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8
Akademický článek
Honey Targets Ribosome Biogenesis Components to Suppress the Growth of Human Pancreatic Cancer Cells.
Autor: Bangash, Aun Ali1,2 (AUTHOR) aun.bangash01@utrgv.edu, Alvi, Sahir Sultan1,2 (AUTHOR) muhammad.bangash01@utrgv.edu, Bangash, Muhammad Ali1,2 (AUTHOR) haider.ahsan01@utrgv.edu, Ahsan, Haider1,2 (AUTHOR) shiza.khan01@utrgv.edu, Khan, Shiza1,2 (AUTHOR) rida.shareef01@utrgv.edu, Shareef, Rida1,2 (AUTHOR) georgina.villanueva01@utrgv.edu, Villanueva, Georgina1,2 (AUTHOR) mudassier.ahmad@utrgv.edu, Bansal, Divyam3 (AUTHOR) db65@rice.edu, Ahmad, Mudassier1,2 (AUTHOR) dae.kim@utrgv.edu, Kim, Dae Joon1,2 (AUTHOR) subhash.chauhan@utrgv.edu, Chauhan, Subhash C.1,2 (AUTHOR), Hafeez, Bilal Bin1,2 (AUTHOR) sahir.alvi@utrgv.edu
Publikováno v: Cancers. Oct2024, Vol. 16 Issue 19, p3431. 21p.
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9
Akademický článek
Reprogrammed mRNA translation drives resistance to therapeutic targeting of ribosome biogenesis.
Autor: Kusnadi EP; Peter MacCallum Cancer Centre, Melbourne, Vic, Australia.; Sir Peter MacCallum Department of Oncology, The University of Melbourne, Parkville, Vic, Australia., Trigos AS; Peter MacCallum Cancer Centre, Melbourne, Vic, Australia.; Sir Peter MacCallum Department of Oncology, The University of Melbourne, Parkville, Vic, Australia., Cullinane C; Peter MacCallum Cancer Centre, Melbourne, Vic, Australia.; Sir Peter MacCallum Department of Oncology, The University of Melbourne, Parkville, Vic, Australia., Goode DL; Peter MacCallum Cancer Centre, Melbourne, Vic, Australia.; Sir Peter MacCallum Department of Oncology, The University of Melbourne, Parkville, Vic, Australia., Larsson O; Department of Oncology-Pathology, Science for Life Laboratory, Karolinska Institutet, Solna, Sweden., Devlin JR; Peter MacCallum Cancer Centre, Melbourne, Vic, Australia.; Sir Peter MacCallum Department of Oncology, The University of Melbourne, Parkville, Vic, Australia., Chan KT; Peter MacCallum Cancer Centre, Melbourne, Vic, Australia.; Sir Peter MacCallum Department of Oncology, The University of Melbourne, Parkville, Vic, Australia., De Souza DP; Metabolomics Australia, Bio21 Molecular Science and Biotechnology Institute, Parkville, Vic, Australia., McConville MJ; Metabolomics Australia, Bio21 Molecular Science and Biotechnology Institute, Parkville, Vic, Australia.; Department of Biochemistry and Molecular Biology, The University of Melbourne, Parkville, Vic, Australia., McArthur GA; Peter MacCallum Cancer Centre, Melbourne, Vic, Australia.; Sir Peter MacCallum Department of Oncology, The University of Melbourne, Parkville, Vic, Australia., Thomas G; Metabolism and Cancer Group, Molecular Mechanisms and Experimental Therapy In Oncology Program, Bellvitge Biomedical Research Institute, IDIBELL, Barcelona, Spain., Sanij E; Peter MacCallum Cancer Centre, Melbourne, Vic, Australia.; Sir Peter MacCallum Department of Oncology, The University of Melbourne, Parkville, Vic, Australia.; Department of Clinical Pathology, The University of Melbourne, Parkville, Vic, Australia., Poortinga G; Peter MacCallum Cancer Centre, Melbourne, Vic, Australia.; Sir Peter MacCallum Department of Oncology, The University of Melbourne, Parkville, Vic, Australia., Hannan RD; Peter MacCallum Cancer Centre, Melbourne, Vic, Australia.; Sir Peter MacCallum Department of Oncology, The University of Melbourne, Parkville, Vic, Australia.; Department of Biochemistry and Molecular Biology, The University of Melbourne, Parkville, Vic, Australia.; ACRF Department of Cancer Biology and Therapeutics, The John Curtin School of Medical Research, Acton, ACT, Australia.; Department of Biochemistry and Molecular Biology, Monash University, Clayton, Vic, Australia.; School of Biomedical Sciences, University of Queensland, Brisbane, Qld, Australia., Hannan KM; Department of Biochemistry and Molecular Biology, The University of Melbourne, Parkville, Vic, Australia.; ACRF Department of Cancer Biology and Therapeutics, The John Curtin School of Medical Research, Acton, ACT, Australia., Kang J; Peter MacCallum Cancer Centre, Melbourne, Vic, Australia.; Sir Peter MacCallum Department of Oncology, The University of Melbourne, Parkville, Vic, Australia., Pearson RB; Peter MacCallum Cancer Centre, Melbourne, Vic, Australia.; Sir Peter MacCallum Department of Oncology, The University of Melbourne, Parkville, Vic, Australia.; Department of Biochemistry and Molecular Biology, The University of Melbourne, Parkville, Vic, Australia.; Department of Biochemistry and Molecular Biology, Monash University, Clayton, Vic, Australia.
Publikováno v: The EMBO journal [EMBO J] 2020 Nov 02; Vol. 39 (21), pp. e105111. Date of Electronic Publication: 2020 Sep 18.
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10
Akademický článek
rDNA Chromatin Activity Status as a Biomarker of Sensitivity to the RNA Polymerase I Transcription Inhibitor CX-5461.
Autor: Son J; Peter MacCallum Cancer Centre, Melbourne, VIC, Australia.; Sir Peter MacCallum Department of Oncology, The University of Melbourne, Parkville, VIC, Australia., Hannan KM; ACRF Department of Cancer Biology and Therapeutics, The John Curtin School of Medical Research, Australian National University, Canberra, ACT, Australia.; Department of Biochemistry and Molecular Biology, The University of Melbourne, Parkville, VIC, Australia., Poortinga G; Peter MacCallum Cancer Centre, Melbourne, VIC, Australia.; Sir Peter MacCallum Department of Oncology, The University of Melbourne, Parkville, VIC, Australia.; Department of Medicine, St. Vincent's Hospital, The University of Melbourne, Parkville, VIC, Australia., Hein N; ACRF Department of Cancer Biology and Therapeutics, The John Curtin School of Medical Research, Australian National University, Canberra, ACT, Australia., Cameron DP; ACRF Department of Cancer Biology and Therapeutics, The John Curtin School of Medical Research, Australian National University, Canberra, ACT, Australia., Ganley ARD; School of Biological Sciences, The University of Auckland, Auckland, New Zealand., Sheppard KE; Peter MacCallum Cancer Centre, Melbourne, VIC, Australia.; Sir Peter MacCallum Department of Oncology, The University of Melbourne, Parkville, VIC, Australia.; Department of Biochemistry and Molecular Biology, The University of Melbourne, Parkville, VIC, Australia., Pearson RB; Peter MacCallum Cancer Centre, Melbourne, VIC, Australia.; Sir Peter MacCallum Department of Oncology, The University of Melbourne, Parkville, VIC, Australia.; Department of Biochemistry and Molecular Biology, The University of Melbourne, Parkville, VIC, Australia.; Department of Biochemistry and Molecular Biology, Monash University, Clayton, VIC, Australia., Hannan RD; Peter MacCallum Cancer Centre, Melbourne, VIC, Australia.; Sir Peter MacCallum Department of Oncology, The University of Melbourne, Parkville, VIC, Australia.; ACRF Department of Cancer Biology and Therapeutics, The John Curtin School of Medical Research, Australian National University, Canberra, ACT, Australia.; Department of Biochemistry and Molecular Biology, The University of Melbourne, Parkville, VIC, Australia.; Department of Biochemistry and Molecular Biology, Monash University, Clayton, VIC, Australia.; School of Biomedical Sciences, The University of Queensland, Brisbane, QLD, Australia., Sanij E; Peter MacCallum Cancer Centre, Melbourne, VIC, Australia.; Sir Peter MacCallum Department of Oncology, The University of Melbourne, Parkville, VIC, Australia.; Department of Clinical Pathology, The University of Melbourne, Parkville, VIC, Australia.
Publikováno v: Frontiers in cell and developmental biology [Front Cell Dev Biol] 2020 Jul 03; Vol. 8, pp. 568. Date of Electronic Publication: 2020 Jul 03 (Print Publication: 2020).
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