Zobrazeno 1 - 10
of 143
pro vyhledávání: '"Poornima Bhat‐Nakshatri"'
Autor:
Adedeji K. Adebayo, Poornima Bhat-Nakshatri, Christopher Davis, Steven P. Angus, Cihat Erdogan, Hongyu Gao, Nick Green, Brijesh Kumar, Yunlong Liu, Harikrishna Nakshatri
Publikováno v:
iScience, Vol 27, Iss 6, Pp 110068- (2024)
Summary: Most cells in solid tumors are exposed to oxygen levels between 0.5% and 5%. We developed an approach that allows collection, processing, and evaluation of cancer and non-cancer cells under physioxia, while preventing exposure to ambient air
Externí odkaz:
https://doaj.org/article/b300f7aa46a649b784ca542379c4f5b4
Autor:
Brijesh Kumar, Aditi S. Khatpe, Jiang Guanglong, Katie Batic, Poornima Bhat-Nakshatri, Maggie M. Granatir, Rebekah Joann Addison, Megan Szymanski, Lee Ann Baldridge, Constance J. Temm, George Sandusky, Sandra K. Althouse, Michele L. Cote, Kathy D. Miller, Anna Maria Storniolo, Harikrishna Nakshatri
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-22 (2023)
Abstract The biologic basis of genetic ancestry-dependent variability in disease incidence and outcome is just beginning to be explored. We recently reported enrichment of a population of ZEB1-expressing cells located adjacent to ductal epithelial ce
Externí odkaz:
https://doaj.org/article/75421f2ad75f4636aa0061e39d6146f1
Autor:
Ruizhong Wang, Brijesh Kumar, Poornima Bhat-Nakshatri, Aditi S. Khatpe, Michael P. Murphy, Kristen E. Wanczyk, Edward Simpson, Duojiao Chen, Hongyu Gao, Yunlong Liu, Emma H. Doud, Amber L. Mosley, Harikrishna Nakshatri
Publikováno v:
iScience, Vol 26, Iss 4, Pp 106541- (2023)
Summary: Skeletal muscle dysfunction or reprogramming due to the effects of the cancer secretome is observed in multiple malignancies. Although mouse models are routinely used to study skeletal muscle defects in cancer, because of species specificity
Externí odkaz:
https://doaj.org/article/1438aa9d57ba4cedbd600e0d5b03d86c
Autor:
Ruizhong Wang, Brijesh Kumar, Poornima Bhat‐Nakshatri, Mayuri S. Prasad, Max H. Jacobsen, Gabriela Ovalle, Calli Maguire, George Sandusky, Trupti Trivedi, Khalid S. Mohammad, Theresa Guise, Narsimha R. Penthala, Peter A. Crooks, Jianguo Liu, Teresa Zimmers, Harikrishna Nakshatri
Publikováno v:
JCSM Rapid Communications, Vol 4, Iss 1, Pp 24-39 (2021)
Abstract Background Loss of skeletal muscle volume and functional limitations are poor prognostic markers in breast cancer patients. Several molecular defects in skeletal muscle including reduced myoblast determination protein 1 (MyoD) levels and inc
Externí odkaz:
https://doaj.org/article/a00e580af8d34f4daa2fee42e2201e27
Autor:
Poornima Bhat-Nakshatri, Natascia Marino, Hongyu Gao, Yunlong Liu, Anna Maria Storniolo, Harikrishna Nakshatri
Publikováno v:
STAR Protocols, Vol 3, Iss 1, Pp 101047- (2022)
Summary: The Komen Tissue Bank is the only biorepository in the world for normal breast tissues from women. Below we report the acquisition and processing of breast tissue from volunteer donors and describe an experimental and analysis pipeline to ge
Externí odkaz:
https://doaj.org/article/cbc19e52813c4bfabab587e5da1e5ff3
Autor:
Maria B. Padua, Poornima Bhat-Nakshatri, Manjushree Anjanappa, Mayuri S. Prasad, Yangyang Hao, Xi Rao, Sheng Liu, Jun Wan, Yunlong Liu, Kyle McElyea, Max Jacobsen, George Sandusky, Sandra Althouse, Susan Perkins, Harikrishna Nakshatri
Publikováno v:
Breast Cancer Research, Vol 20, Iss 1, Pp 1-18 (2018)
Abstract Background The majority of estrogen receptor-positive (ERα+) breast cancers respond to endocrine therapies. However, resistance to endocrine therapies is common in 30% of cases, which may be due to altered ERα signaling and/or enhanced pla
Externí odkaz:
https://doaj.org/article/6004230c8bc3416caaf80c8075bbf814
Autor:
Aditi S. Khatpe, Rebecca Dirks, Poornima Bhat-Nakshatri, Henry Mang, Katie Batic, Sarah Swiezy, Jacob Olson, Xi Rao, Yue Wang, Hiromi Tanaka, Sheng Liu, Jun Wan, Duojiao Chen, Yunlong Liu, Fang Fang, Sandra Althouse, Emily Hulsey, Maggie M. Granatir, Rebekah Addison, Constance J. Temm, George Sandusky, Audrey Lee-Gosselin, Kenneth Nephew, Kathy D. Miller, Harikrishna Nakshatri
Publikováno v:
Cancer Research. 83:1345-1360
Study of genomic aberrations leading to immortalization of epithelial cells has been technically challenging due to the lack of isogenic models. To address this, we used healthy primary breast luminal epithelial cells of different genetic ancestry an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d80bdbe8f7e3fd859b87ba6cb6728f30
https://doi.org/10.1158/0008-5472.can-22-3667
https://doi.org/10.1158/0008-5472.can-22-3667
Autor:
Brijesh Kumar, Katie Batic, Poornima Bhat-Nakshatri, Maggie Granatir, Rebekah Addison, Megan Szymanski, Lee Ann Baldridge, Constance Temm, George Sandusky, Sandra Althouse, Anna Maria Storniolo, Harikrishna Nakshatri
Publikováno v:
Cancer Research. 83:P2-26
The biologic basis of genetic ancestry-dependent variability in disease incidence and outcome is just beginning to be explored. We recently reported enrichment of a population of ZEB1-expressing cells located adjacent to the ductal epithelial cells i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f8ea1b1476e1debcdc6c7d05ca39d6c3
https://doi.org/10.1158/1538-7445.sabcs22-p2-26-08
https://doi.org/10.1158/1538-7445.sabcs22-p2-26-08
Autor:
Harikrishna Nakshatri, Kathy D. Miller, Kenneth Nephew, Audrey Lee-Gosselin, George Sandusky, Constance J. Temm, Rebekah Addison, Maggie M. Granatir, Emily Hulsey, Sandra Althouse, Fang Fang, Yunlong Liu, Duojiao Chen, Jun Wan, Sheng Liu, Hiromi Tanaka, Yue Wang, Xi Rao, Jacob Olson, Sarah Swiezy, Katie Batic, Henry Mang, Poornima Bhat-Nakshatri, Rebecca Dirks, Aditi S. Khatpe
Table S9: Results of ATAC-seq of primary and TONSL-immortalized cells.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2aebc890399e5bfe96f54d95a43428de
https://doi.org/10.1158/0008-5472.22633261.v1
https://doi.org/10.1158/0008-5472.22633261.v1
Autor:
Harikrishna Nakshatri, Kathy D. Miller, Kenneth Nephew, Audrey Lee-Gosselin, George Sandusky, Constance J. Temm, Rebekah Addison, Maggie M. Granatir, Emily Hulsey, Sandra Althouse, Fang Fang, Yunlong Liu, Duojiao Chen, Jun Wan, Sheng Liu, Hiromi Tanaka, Yue Wang, Xi Rao, Jacob Olson, Sarah Swiezy, Katie Batic, Henry Mang, Poornima Bhat-Nakshatri, Rebecca Dirks, Aditi S. Khatpe
Study of genomic aberrations leading to immortalization of epithelial cells has been technically challenging due to the lack of isogenic models. To address this, we used healthy primary breast luminal epithelial cells of different genetic ancestry an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6a02b10f9fff51b50bf5355116b3f214
https://doi.org/10.1158/0008-5472.c.6599674.v1
https://doi.org/10.1158/0008-5472.c.6599674.v1