Výsledky vyhledávání - "Poorna Piyathilaka"

Identification of 3-O-α-l-arabinosyl oleanolic acid, a triterpenoid saponin, as a new breast cancer stem cell growth inhibitor

Autor: Meran Keshawa Ediriweera, Sameera R. Samarakoon, Umapriyatharshini Rajagopalan, Poorna Piyathilaka, Dennis Kariuki Muthoni, Kamani H. Tennekoon

Publikováno v: Natural Product Research. 36:2923-2926

This study was conducted to determine the anti-cancer activity of 3-O-α-L-arabinosyl oleanolic acid (3-O-L-AO), a triterpenoid saponin, isolated from the leaves of Schumacheria castaneifolia Vahl in breast cancer stem cells (bCSCs) grown in hypoxia.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::fc859cdd64c762c721c524dddd390ae3
https://doi.org/10.1080/14786419.2021.1933971

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Hexane Extract of

Autor: Varuni, Colamba Pathiranage, Jesiska Nirmalee, Lowe, Umapriyatharshini, Rajagopalan, Meran Keshawa, Ediriweera, Kanishka, Senathilake, Poorna, Piyathilaka, Kamani Hemamala, Tennekoon, Sameera Ranganath, Samarakoon

Publikováno v: Nutrition and cancer. 73(5)

Development of therapy resistance is a major clinical issue in breast cancer treatments. Breast cancer stem cells (bCSCs) have a clearly defined role in the development of breast cancer therapy resistance and tumor recurrence. Therefore, discovery of

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::ffb01a14cba9dddd7cac50b47c3d03fd
https://pubmed.ncbi.nlm.nih.gov/32482103

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A Study on Cytotoxic and Apoptotic Potential of a Triterpenoid Saponin (3-O-α-L-Arabinosyl Oleanolic Acid) Isolated fromSchumacheria castaneifoliaVahl in Human Non-Small-Cell Lung Cancer (NCI-H292) Cells

Autor: Veranja Karunaratne, Chukwumaobim Daniel Uzochukwuwulu Nwokwu, Chamara Janaka Bandara, Meran Keshawa Ediriweera, Kamani H. Tennekoon, Poorna Piyathilaka, Sameera R. Samarakoon, D. Nedra Karunaratne

Publikováno v: BioMed Research International. 2017:1-8

Lung cancer is the major cause of cancer death among men. A number of natural compounds have proven to be useful in the treatmet of lung cancer. This study was aimed to determine cytotoxic and apoptotoic effects of a natural compound 3-O-α-L-arabino

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::3d0e58451e373938753af21f94587602
https://doi.org/10.1155/2017/9854083

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Screening of Fifteen Mangrove Plants Found in Sri Lanka for in-vitro Cytotoxic Properties on Breast (MCF-7) and Hepatocellular Carcinoma (HepG2) Cells

Autor: Ira Thabrew, Sameera R. Samarakoon, Meran Keshawa Ediriweera, Kamani H. Tennekoon, Poorna Piyathilaka, Chanthirika Shanmuganathan

Publikováno v: European Journal of Medicinal Plants. 14:1-11

Aims: Evaluation of cytotoxic potential on the leaves and stem bark extracts of 15 mangrove plants grown in Sri Lanka on breast cancer (MCF -7) and hepatocellular carcinoma (HepG2) cells. Place and Duration of Study: At the Institute of Biochemistry,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::2fd9924f127b1a81fe0cbf0243888416
https://doi.org/10.9734/ejmp/2016/26107

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A Study on Cytotoxic and Apoptotic Potential of a Triterpenoid Saponin (3-O

Autor: Sameera R, Samarakoon, Meran K, Ediriweera, Chukwumaobim Daniel Uzochukwuwulu, Nwokwu, Chamara Janaka, Bandara, Kamani H, Tennekoon, Poorna, Piyathilaka, D Nedra, Karunaratne, Veranja, Karunaratne

Publikováno v: BioMed Research International

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::6ad1a692a7f23af2b7129aebf092b5e0
https://pubmed.ncbi.nlm.nih.gov/29259993

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A Study on Cytotoxic and Apoptotic Potential of a Triterpenoid Saponin (3-O-α-L-Arabinosyl Oleanolic Acid) Isolated from Schumacheria castaneifolia Vahl in Human Non-Small-Cell Lung Cancer (NCI-H292) Cells

Autor: Sameera R. Samarakoon, Meran K. Ediriweera, Chukwumaobim Daniel Uzochukwuwulu Nwokwu, Chamara Janaka Bandara, Kamani H. Tennekoon, Poorna Piyathilaka, D. Nedra Karunaratne, Veranja Karunaratne

Publikováno v: BioMed Research International, Vol 2017 (2017)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::2c292b3199db5eb46844e87c26a533f7

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In Vitro Anticancer Effect of Gedunin on Human Teratocarcinomal (NTERA-2) Cancer Stem-Like Cells

Autor: Kanishka Senathilake, Ira Thabrew, Umapriyatharshini Rajagopalan, Sameera R. Samarakoon, Prasanna B Galhena, Luxmiga Tharmarajah, Kamani H. Tennekoon, Poorna Piyathilaka, Meran Keshawa Ediriweera

Publikováno v: BioMed Research International, Vol 2017 (2017)
BioMed Research International

Gedunin is one of the major compounds found in the neem tree(Azadirachta indica). In the present study, antiproliferative potential of gedunin was evaluated in human embryonal carcinoma cells (NTERA-2, a cancer stem cell model) and peripheral blood m

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8b9e5dea26f117d755e59a91742adaee
https://doaj.org/article/a7b0dec323e24c7893a63d90ae1ecd50

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Evaluation of the Impact of Natural Microcystin-LR Extract on Brine Shrimp as an Invertebrate Bioassay Model

Autor: Poorna Piyathilaka, Pathmalal M. Manage

Publikováno v: Proceedings of International Forestry and Environment Symposium. 18

Frequent occurrences of toxic cyanobacteria dominantly Microcystis aeruginosa bloom arebecoming a nuisance problem in Sri Lankan reservoirs in conformity with its globalenvironmental and health issues. Most of cyanobacteria produce heat stable cyanot

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::d05f3a89d251ff3ec796469f943f05fe
https://doi.org/10.31357/fesympo.v18i0.1895

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