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Exploring the Impact of Intestinal Fluid Components on the Solubility and Supersaturation of Danazol

Autor: Thomas Rades, Anette Müllertz, Jakob Plum, Patrick Augustijns, Bart Hens, Cecilie Maria Madsen

Publikováno v: Madsen, C M, Plum, J, Hens, B, Augustijns, P, Mullertz, A & Rades, T 2021, ' Exploring the Impact of Intestinal Fluid Components on the Solubility and Supersaturation of Danazol ', Journal of Pharmaceutical Sciences, vol. 110, no. 6, pp. 2479-2488 . https://doi.org/10.1016/j.xphs.2020.12.039

Eleven simulated intestinal fluids (SIF) were designed using a Design of Experiment (DoE) approach. The DoE SIF covered a range of compositions of fasted state human intestinal fluid (FaHIF) with regard to pH, bile salt (BS), and phospholipid (PL). U

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f916e21b57cc57594492747b792eded3
https://doi.org/10.1016/j.xphs.2020.12.039

Novel Thermosensitive Polymer-Modified Liposomes as Nano-Carrier of Hydrophobic Antitumor Drugs

Autor: Yuandou Wang, Suming Li, Yanling Gong, Laishun Xi, Feng Su, Chenglong Li

Publikováno v: Journal of Pharmaceutical Sciences
Journal of Pharmaceutical Sciences, Wiley, 2020, 109 (8), pp.2544-2552. ⟨10.1016/j.xphs.2020.05.006⟩

International audience; Thermo-sensitive polymer-modified liposomes are able to achieve site-specific delivery of drugs. In this work, thermo-sensitive polymers were synthesized by atomic transfer radical polymerization of N-isopropyl acrylamide (NIP

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::462dd2e816143af23012cb5e32e57477
https://hal.archives-ouvertes.fr/hal-03093011/document

Fabrication of Submicrometer-Sized Meloxicam Particles Using Femtosecond Laser Ablation in Gas and Liquid Environments

Autor: Zoltán Bozóki, Fruzsina Kun-Szabó, Rita Ambrus, Béla Hopp, Tamás Smausz, Tibor Ajtai, Judit Kopniczky, Attila Andrásik, Eszter Nagy, Piroska Szabó-Révész

Publikováno v: Nanomaterials
Volume 11
Issue 4
Nanomaterials, Vol 11, Iss 996, p 996 (2021)

In pharmaceutical development, more and more drugs are classified as poorly water-soluble or insoluble. Particle size reduction is a common way to fight this trend by improving dissolution rate, transport characteristics and bioavailability. Pulsed l

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::01cb1afb84ed227f099702ec9638d5b5
https://doi.org/10.3390/nano11040996