Loss of deacetylation enzymes Hdac6 and Sirt2 promotes acetylation of cytoplasmic tubulin, but suppresses axonemal acetylation in zebrafish cilia

Autor: Łysyganicz, P.K., Pooranachandran, N., Liu, X., Adamson, K.I., Zielonka, K., Elworthy, S., van Eeden, F.J., Grierson, A.J., Malicki, J.J.

Cilia are evolutionarily highly conserved organelles with important functions in many organs. The extracellular component of the cilium protruding from the plasma membrane comprises an axoneme composed of microtubule doublets, arranged in a 9 + 0 con

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Loss of Deacetylation Enzymes Hdac6 and Sirt2 Promotes Acetylation of Cytoplasmic Tubulin, but Suppresses Axonemal Acetylation in Zebrafish Cilia.

Autor: Łysyganicz PK; The Bateson Centre, The University of Sheffield, Sheffield, United Kingdom.; Department of Biomedical Science, University of Sheffield, Sheffield, United Kingdom., Pooranachandran N; Department of Biomedical Science, University of Sheffield, Sheffield, United Kingdom., Liu X; The School of Clinical Dentistry, The University of Sheffield, Sheffield, United Kingdom., Adamson KI; The Bateson Centre, The University of Sheffield, Sheffield, United Kingdom.; Sheffield Institute for Translational Neuroscience, University of Sheffield, Sheffield, United Kingdom., Zielonka K; The Bateson Centre, The University of Sheffield, Sheffield, United Kingdom.; Department of Biomedical Science, University of Sheffield, Sheffield, United Kingdom., Elworthy S; The Bateson Centre, The University of Sheffield, Sheffield, United Kingdom.; Department of Biomedical Science, University of Sheffield, Sheffield, United Kingdom., van Eeden FJ; The Bateson Centre, The University of Sheffield, Sheffield, United Kingdom.; Department of Biomedical Science, University of Sheffield, Sheffield, United Kingdom., Grierson AJ; The Bateson Centre, The University of Sheffield, Sheffield, United Kingdom.; Sheffield Institute for Translational Neuroscience, University of Sheffield, Sheffield, United Kingdom., Malicki JJ; The Bateson Centre, The University of Sheffield, Sheffield, United Kingdom.; Department of Biomedical Science, University of Sheffield, Sheffield, United Kingdom.

Publikováno v: Frontiers in cell and developmental biology [Front Cell Dev Biol] 2021 Jun 28; Vol. 9, pp. 676214. Date of Electronic Publication: 2021 Jun 28 (Print Publication: 2021).