Zobrazeno 1 - 10
of 211
pro vyhledávání: '"Poonkuzhali Balasubramanian"'
Autor:
Kirti Prasad, Nivedhitha Devaraju, Anila George, Nithin Sam Ravi, Joshua Paul, Gokulnath Mahalingam, Vignesh Rajendiran, Lokesh Panigrahi, Vigneshwaran Venkatesan, Kartik Lakhotiya, Yogapriya Periyasami, Aswin Anand Pai, Yukio Nakamura, Ryo Kurita, Poonkuzhali Balasubramanian, Saravanabhavan Thangavel, Shaji R. Velayudhan, Gregory A. Newby, Srujan Marepally, Alok Srivastava, Kumarasamypet M. Mohankumar
Publikováno v:
Molecular Therapy: Nucleic Acids, Vol 35, Iss 2, Pp 102205- (2024)
β-thalassemia/HbE results from mutations in the β-globin locus that impede the production of functional adult hemoglobin. Base editors (BEs) could facilitate the correction of the point mutations with minimal or no indel creation, but its efficienc
Externí odkaz:
https://doaj.org/article/1c5f0f013cfe4f2da711f4e85aae51fa
Autor:
Smitha Ijee, Karthik Chambayil, Anurag Dutta Chaudhury, Abhirup Bagchi, Kirti Modak, Saswati Das, Esther Sathya Bama Benjamin, Sonam Rani, Daniel Zechariah Paul, Aneesha Nath, Debanjan Roy, Dhavapriya Palani, Sweety Priyanka, Rakshini Ravichandran, Betty K. Kumary, Yazhini Sivamani, Vijayanand S., Dinesh Babu, Yukio Nakamura, Vasanth Thamodaran, Poonkuzhali Balasubramanian, Shaji R. Velayudhan
Publikováno v:
Frontiers in Molecular Biosciences, Vol 10 (2024)
MicroRNAs (miRNAs) are short non-coding RNAs that play crucial roles in gene regulation, exerting post-transcriptional silencing, thereby influencing cellular function, development, and disease. Traditional loss-of-function methods for studying miRNA
Externí odkaz:
https://doaj.org/article/5312775f75e844e48f5507f1e9c2a7d8
Autor:
Vigneshwaran Venkatesan, Abisha Crystal Christopher, Manuel Rhiel, Manoj Kumar K. Azhagiri, Prathibha Babu, Kaivalya Walavalkar, Bharath Saravanan, Geoffroy Andrieux, Sumathi Rangaraj, Saranya Srinivasan, Karthik V. Karuppusamy, Annlin Jacob, Abhirup Bagchi, Aswin Anand Pai, Yukio Nakamura, Ryo Kurita, Poonkuzhali Balasubramanian, Rekha Pai, Srujan Kumar Marepally, Kumarasamypet Murugesan Mohankumar, Shaji R. Velayudhan, Melanie Boerries, Dimple Notani, Toni Cathomen, Alok Srivastava, Saravanabhavan Thangavel
Publikováno v:
Molecular Therapy: Nucleic Acids, Vol 32, Iss , Pp 671-688 (2023)
Reactivation of fetal hemoglobin (HbF) is a commonly adapted strategy to ameliorate β-hemoglobinopathies. However, the continued production of defective adult hemoglobin (HbA) limits HbF tetramer production affecting the therapeutic benefits. Here,
Externí odkaz:
https://doaj.org/article/444686798a7c40d7a355be2ff089b162
Autor:
Uday Prakash Kulkarni, Sushil Selvarajan, N. A. Fouzia, Sharon Lionel, Sukesh Chandran Nair, Poonkuzhali Balasubramanian, Thenmozhi Mani, Aby Abraham, Biju George, Vikram Mathews
Publikováno v:
Blood Cancer Journal, Vol 13, Iss 1, Pp 1-3 (2023)
Externí odkaz:
https://doaj.org/article/bc2f7a9ed64a4ad794afb96b27359654
Autor:
Uday Kulkarni, Arun Kumar Arunachalam, Hamenth Kumar Palani, Reeshma Radhakrishnan Nair, Nithya Balasundaram, Arvind Venkatraman, Anu Korula, Sushil Selvarajan, Sharon Lionel, Poonkuzhali Balasubramanian, Madhavi Maddali, Aby Abraham, Biju George, Vikram Mathews
Publikováno v:
Cell Transplantation, Vol 32 (2023)
Refractory acute myeloid leukemia (AML), defined as failure of two cycles of induction therapy at diagnosis or of one cycle at relapse, represents a subgroup with poor outcomes. Haploidentical natural killer cell (NK) therapy is a strategy that is be
Externí odkaz:
https://doaj.org/article/d4492367022c464e9341fd1d7b0aea08
Autor:
Abhirup Bagchi, Nivedhitha Devaraju, Karthik Chambayil, Vignesh Rajendiran, Vigneshwaran Venkatesan, Nilofer Sayed, Aswin Anand Pai, Aneesha Nath, Ernest David, Yukio Nakamura, Poonkuzhali Balasubramanian, Alok Srivastava, Saravanabhavan Thangavel, Kumarasamypet M. Mohankumar, Shaji R. Velayudhan
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-13 (2022)
Abstract Numerous genes exert multifaceted roles in hematopoiesis. Therefore, we generated novel lineage-specific RNA interference (RNAi) lentiviral vectors, H23B-Ery-Lin-shRNA and H234B-Ery-Lin-shRNA, to probe the functions of these genes in erythro
Externí odkaz:
https://doaj.org/article/63d72c82f4d747819d0e40736513dbbc
Autor:
Bharathi M. Rajamani, Raveen Stephen Stallon Illangeswaran, Esther Sathya Bama Benjamin, Balaji Balakrishnan, Daniel Zechariah Paul Jebanesan, Saswati Das, Aswin Anand Pai, Rakhi Thalayattu Vidhyadharan, Ajith Mohan, Sreeja Karathedath, Aby Abraham, Vikram Mathews, Shaji R. Velayudhan, Poonkuzhali Balasubramanian
Publikováno v:
Frontiers in Pharmacology, Vol 14 (2023)
Introduction: The ligand-activated transcription factors, nuclear hormone receptors (NHRs), remain unexplored in hematological malignancies except for retinoic acid receptor alpha (RARA).Methods: Here we profiled the expression of various NHRs and th
Externí odkaz:
https://doaj.org/article/819afb142194448295ce19c5008ae927
Autor:
Uday P. Kulkarni, Sushil Selvarajan, Sharon Lionel, Mithun A. Prakash, Hamenth Kumar Palani, Nithya Balasundaram, Arvind Venkataraman, Anu Korula, Anup J. Devasia, N. A. Fouzia, Nancy Beryl Janet, Sukesh Chandran Nair, Aby Abraham, Thenmozhi Mani, Jeyaseelan Lakshmanan, Arun Kumar Arunachalam, Poonkuzhali Balasubramanian, Biju George, Vikram Mathews
Publikováno v:
Blood Cancer Journal, Vol 12, Iss 1, Pp 1-4 (2022)
Externí odkaz:
https://doaj.org/article/25cb0d759bef4dba8c63d0c125449bb1
Publikováno v:
Türk Patoloji Dergisi, Vol 38, Iss 1, Pp 025-033 (2022)
Objective: Recent WHO 2017 guidelines mandates mutational analysis for the diagnosis of myeloproliferative disorders (MPN). JAK2V617F has been found in only 50-60% of Primary myelofibrosis (PMF) and Essential thrombocythaemia (ET). A recently discove
Externí odkaz:
https://doaj.org/article/9b6c57cf8cba4570936e1a9c174d4052
Autor:
Balaji Balakrishnan, Uday Prakash Kulkarni, Aswin Anand Pai, Raveen Stephen Stallon Illangeswaran, Ezhilpavai Mohanan, Vikram Mathews, Biju George, Poonkuzhali Balasubramanian
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
Hematopoietic cell transplantation is an established curative treatment option for various hematological malignant, and non-malignant diseases. However, the success of HCT is still limited by life-threatening early complications post-HCT, such as Gra
Externí odkaz:
https://doaj.org/article/40636592f0bb439b94d150821c626b10