Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Poonam Rath"'
Publikováno v:
PLoS ONE, Vol 13, Iss 10, p e0200147 (2018)
When we get sick, we want to be resilient and recover our original health. To measure resilience, we need to quantify a host's position along its disease trajectory. Here we present Looper, a computational method to analyze longitudinally gathered da
Externí odkaz:
https://doaj.org/article/c5fb8b95c197480d942459dd8740b81e
Autor:
Brenda Y Torres, Jose Henrique M Oliveira, Ann Thomas Tate, Poonam Rath, Katherine Cumnock, David S Schneider
Publikováno v:
PLoS Biology, Vol 14, Iss 4, p e1002436 (2016)
Infected hosts differ in their responses to pathogens; some hosts are resilient and recover their original health, whereas others follow a divergent path and die. To quantitate these differences, we propose mapping the routes infected individuals tak
Externí odkaz:
https://doaj.org/article/416477899d5241109ed8810b2d51ded3
Autor:
Aimee M Beaulieu, Poonam Rath, Marianne Imhof, Mark E Siddall, Julia Roberts, Dirk Schnappinger, Carl F Nathan
Publikováno v:
PLoS ONE, Vol 5, Iss 12, p e15120 (2010)
In spite of its highly immunogenic properties, Mycobacterium tuberculosis (Mtb) establishes persistent infection in otherwise healthy individuals, making it one of the most widespread and deadly human pathogens. Mtb's prolonged survival may reflect p
Externí odkaz:
https://doaj.org/article/928683ad08f44e719a5cf82b82d7400c
Publikováno v:
PLoS ONE
PLoS ONE, Vol 13, Iss 10, p e0200147 (2018)
PLoS ONE, Vol 13, Iss 10, p e0200147 (2018)
When we get sick, we want to be resilient and recover our original health. To measure resilience, we need to quantify a host's position along its disease trajectory. Here we present Looper, a computational method to analyze longitudinally gathered da
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::46d919febf710494c16a9fb5334c61ce
https://pubmed.ncbi.nlm.nih.gov/30296270
https://pubmed.ncbi.nlm.nih.gov/30296270
Autor:
J. Fraser Glickman, Carl Nathan, Ouathek Ouerfelli, Crystal M. Darby, Xiuju Jiang, Poonam Rath, Julia Roberts, Eric L. Nuermberger, Tamutenda Chidawanyika, Maneesh Pingle, J. David Warren, Selin Somersan, Haiteng Deng, Aditya Venugopal, Ronald Realubit, Ben Gold, Steven J. Brickner, Amy Cunningham-Bussel, Thulasi Warrier, Mark Rundell, Joseph Fernandez, Nilesh Shah, W. Clay Bracken
Publikováno v:
Proceedings of the National Academy of Sciences. 109:16004-16011
Existing drugs are slow to eradicate Mycobacterium tuberculosis (Mtb) in patients and have failed to control tuberculosis globally. One reason may be that host conditions impair Mtb’s replication, reducing its sensitivity to most antiinfectives. We
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::84b9194f8d497320900ae78e6197c007
https://doi.org/10.1073/pnas.1214188109
https://doi.org/10.1073/pnas.1214188109
Autor:
Kang Chen, Norman W. Miller, Paul A. Santini, Andrea Cerutti, Weifeng Xu, Kristian Riesbeck, Poonam Rath, Marco Cattalini, Jiri Litzman, Melanie Wilson, Eva-Stina Edholm, Eva Bengtén, Bihui Huang, James B. Bussel, Charlotte Cunningham-Rundles, Bing He, Alessandro Plebani, April Chiu, Antonella Meini
Publikováno v:
Nature immunology
Immunoglobulin D (IgD) is an enigmatic antibody isotype that mature B cells express together with IgM through alternative RNA splicing. Here we report active T cell-dependent and T cell-independent IgM-to-IgD class switching in B cells of the human u
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9a2aee2dc2efd00a289aa3f7fb860d52
http://europepmc.org/articles/PMC2785232
http://europepmc.org/articles/PMC2785232
Autor:
Tao Wang, Olivier Elemento, Chengdong Huang, Tianzhi Wang, Huilin Li, Arturo Casadevall, Carl Nathan, Rafael Prados-Rosales, Poonam Rath
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America. 110(49)
Significance Bacteria stimulate host cells in part via secreted products, some of which are packaged in membrane vesicles (MV). MV released by the major human pathogen Mycobacterium tuberculosis (Mtb) carry lipoprotein LpqH, a major agonist for host
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::576acb4e861f7d102c50e06f35117593
https://pubmed.ncbi.nlm.nih.gov/24248369
https://pubmed.ncbi.nlm.nih.gov/24248369
Autor:
Katherine Cumnock, David Schneider, Jose Henrique M. Oliveira, Brenda Y. Torres, Poonam Rath, Ann T. Tate
Publikováno v:
PLoS Biology
PLoS Biology, Vol 14, Iss 4, p e1002436 (2016)
PLoS Biology, Vol 14, Iss 4, p e1002436 (2016)
Infected hosts differ in their responses to pathogens; some hosts are resilient and recover their original health, whereas others follow a divergent path and die. To quantitate these differences, we propose mapping the routes infected individuals tak
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::db1daac53dc0fbf41974e6d8890a0b4d
https://doi.org/10.1371/journal.pbio.1002436
https://doi.org/10.1371/journal.pbio.1002436
Autor:
Carl Nathan, Ruslana Bryk, Dirk Schnappinger, Shuangping Shi, Aditya Venugopal, Kyu Y. Rhee, Sabine Ehrt, Poonam Rath
Publikováno v:
Cell hostmicrobe. 9(1)
SummaryMycobacterium tuberculosis (Mtb) adapts to persist in a nutritionally limited macrophage compartment. Lipoamide dehydrogenase (Lpd), the third enzyme (E3) in Mtb's pyruvate dehydrogenase complex (PDH), also serves as E1 of peroxynitrite reduct
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b273e27763d0d2a544ec31ee8d8cbe0a
https://pubmed.ncbi.nlm.nih.gov/21238944
https://pubmed.ncbi.nlm.nih.gov/21238944