Heat selection enables highly scalable methylome profiling in cell-free DNA for noninvasive monitoring of cancer patients.

Autor: Cheruba E; Department of Biomedical Engineering, Faculty of Engineering, National University of Singapore, Singapore 117583, Singapore.; Institute for Health Innovation and Technology, National University of Singapore, Singapore 117599, Singapore., Viswanathan R; Department of Biomedical Engineering, Faculty of Engineering, National University of Singapore, Singapore 117583, Singapore.; Institute for Health Innovation and Technology, National University of Singapore, Singapore 117599, Singapore., Wong PM; Genome Institute of Singapore, Agency for Science, Technology, and Research, Singapore 138672, Singapore., Womersley HJ; Department of Biomedical Engineering, Faculty of Engineering, National University of Singapore, Singapore 117583, Singapore.; Institute for Health Innovation and Technology, National University of Singapore, Singapore 117599, Singapore., Han S; Division of Medical Oncology, National Cancer Centre Singapore, Singapore 169610, Singapore., Tay B; Division of Medical Oncology, National Cancer Centre Singapore, Singapore 169610, Singapore., Lau Y; Genome Institute of Singapore, Agency for Science, Technology, and Research, Singapore 138672, Singapore., Gan A; Genome Institute of Singapore, Agency for Science, Technology, and Research, Singapore 138672, Singapore., Poon PSY; Genome Institute of Singapore, Agency for Science, Technology, and Research, Singapore 138672, Singapore., Skanderup A; Genome Institute of Singapore, Agency for Science, Technology, and Research, Singapore 138672, Singapore.; Division of Medical Oncology, National Cancer Centre Singapore, Singapore 169610, Singapore., Ng SB; Genome Institute of Singapore, Agency for Science, Technology, and Research, Singapore 138672, Singapore., Chok AY; Department of Colorectal Surgery, Singapore General Hospital, Singapore 169608, Singapore., Chong DQ; Division of Medical Oncology, National Cancer Centre Singapore, Singapore 169610, Singapore.; Duke-NUS Medical School, National University of Singapore, Singapore 169857, Singapore., Tan IB; Genome Institute of Singapore, Agency for Science, Technology, and Research, Singapore 138672, Singapore.; Division of Medical Oncology, National Cancer Centre Singapore, Singapore 169610, Singapore.; Duke-NUS Medical School, National University of Singapore, Singapore 169857, Singapore., Cheow LF; Department of Biomedical Engineering, Faculty of Engineering, National University of Singapore, Singapore 117583, Singapore.; Institute for Health Innovation and Technology, National University of Singapore, Singapore 117599, Singapore.

Publikováno v: Science advances [Sci Adv] 2022 Sep 09; Vol. 8 (36), pp. eabn4030. Date of Electronic Publication: 2022 Sep 09.

Genomic and epigenomic EBF1 alterations modulate TERT expression in gastric cancer.

Autor: Xing M; Cancer and Stem Cell Biology Program, Duke-NUS Medical School, Singapore.; Cancer Therapeutics and Stratified Oncology, Genome Institute of Singapore, Singapore.; NUS Graduate School for Integrative Sciences and Engineering, National University of Singapore, Singapore., Ooi WF; Cancer Therapeutics and Stratified Oncology, Genome Institute of Singapore, Singapore., Tan J; State Key Laboratory of Oncology in South China, Sun Yat-Sen University Cancer Center, Guangzhou, China.; Laboratory of Cancer Epigenome, Department of Medical Sciences, National Cancer Centre, Singapore., Qamra A; Cancer Therapeutics and Stratified Oncology, Genome Institute of Singapore, Singapore.; NUS Graduate School for Integrative Sciences and Engineering, National University of Singapore, Singapore., Lee PH; Cancer Science Institute of Singapore, National University of Singapore, Singapore., Li Z; Laboratory of Cancer Epigenome, Department of Medical Sciences, National Cancer Centre, Singapore., Xu C; Cancer and Stem Cell Biology Program, Duke-NUS Medical School, Singapore.; Cancer Science Institute of Singapore, National University of Singapore, Singapore., Padmanabhan N; Cancer and Stem Cell Biology Program, Duke-NUS Medical School, Singapore., Lim JQ; Lymphoma Genomic Translational Research Laboratory, Cellular and Molecular Research, National Cancer Centre Singapore, Singapore., Guo YA; Computational and Systems Biology, Agency for Science Technology and Research, Genome Institute of Singapore., Yao X; Institute of Molecular and Cell Biology, Singapore., Amit M; Cancer and Stem Cell Biology Program, Duke-NUS Medical School, Singapore., Ng LM; Cancer Science Institute of Singapore, National University of Singapore, Singapore., Sheng T; Cancer and Stem Cell Biology Program, Duke-NUS Medical School, Singapore.; Department of Biochemistry, National University of Singapore, Singapore., Wang J; Cancer and Stem Cell Biology Program, Duke-NUS Medical School, Singapore., Huang KK; Cancer and Stem Cell Biology Program, Duke-NUS Medical School, Singapore., Anene-Nzelu CG; Cardiovascular Research Institute, National University Health System, Singapore.; Human Genetics, Genome Institute of Singapore, Singapore., Ho SWT; Cancer and Stem Cell Biology Program, Duke-NUS Medical School, Singapore.; Cancer Science Institute of Singapore, National University of Singapore, Singapore., Ray M; Institute for Genomics and Systems Biology, University of Chicago, Chicago, Illinois, USA., Ma L; Institute for Genomics and Systems Biology, University of Chicago, Chicago, Illinois, USA., Fazzi G; Department of Pathology, GROW School for Oncology and Developmental Biology, Maastricht University Medical Center, Maastricht, Netherlands., Lim KJ; Cancer and Stem Cell Biology Program, Duke-NUS Medical School, Singapore., Wijaya GC; Laboratory of Cancer Epigenome, Department of Medical Sciences, National Cancer Centre, Singapore., Zhang S; Cancer and Stem Cell Biology Program, Duke-NUS Medical School, Singapore., Nandi T; Cancer Therapeutics and Stratified Oncology, Genome Institute of Singapore, Singapore., Yan T; Cancer and Stem Cell Biology Program, Duke-NUS Medical School, Singapore., Chang MM; Computational and Systems Biology, Agency for Science Technology and Research, Genome Institute of Singapore., Das K; Cancer and Stem Cell Biology Program, Duke-NUS Medical School, Singapore., Isa ZFA; Cancer Therapeutics and Stratified Oncology, Genome Institute of Singapore, Singapore., Wu J; Cancer and Stem Cell Biology Program, Duke-NUS Medical School, Singapore., Poon PSY; Cancer Therapeutics and Stratified Oncology, Genome Institute of Singapore, Singapore., Lam YN; Cancer Therapeutics and Stratified Oncology, Genome Institute of Singapore, Singapore., Lin JS; Cancer Therapeutics and Stratified Oncology, Genome Institute of Singapore, Singapore., Tay ST; Cancer and Stem Cell Biology Program, Duke-NUS Medical School, Singapore., Lee MH; Cancer and Stem Cell Biology Program, Duke-NUS Medical School, Singapore., Tan ALK; Cancer and Stem Cell Biology Program, Duke-NUS Medical School, Singapore., Ong X; Cancer and Stem Cell Biology Program, Duke-NUS Medical School, Singapore., White K; Institute for Genomics and Systems Biology, University of Chicago, Chicago, Illinois, USA.; Tempus Labs, Chicago, Illinois, USA., Rozen SG; Cancer and Stem Cell Biology Program, Duke-NUS Medical School, Singapore.; SingHealth/Duke-NUS Institute of Precision Medicine, National Heart Centre Singapore, Singapore., Beer M; McKusick-Nathans Institute of Genetic Medicine, Johns Hopkins Medicine, and.; Department of Biomedical Engineering, Johns Hopkins University, Baltimore, Maryland, USA., Foo RSY; Cardiovascular Research Institute, National University Health System, Singapore.; Human Genetics, Genome Institute of Singapore, Singapore., Grabsch HI; Department of Pathology, GROW School for Oncology and Developmental Biology, Maastricht University Medical Center, Maastricht, Netherlands.; Pathology and Data Analyticis, Leeds Institute of Medical Research at St. James's, University of Leeds, Leeds, United Kingdom., Skanderup AJ; Computational and Systems Biology, Agency for Science Technology and Research, Genome Institute of Singapore., Li S; Cancer and Stem Cell Biology Program, Duke-NUS Medical School, Singapore.; Department of Physiology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore., Teh BT; Cancer and Stem Cell Biology Program, Duke-NUS Medical School, Singapore.; Laboratory of Cancer Epigenome, Department of Medical Sciences, National Cancer Centre, Singapore.; Cancer Science Institute of Singapore, National University of Singapore, Singapore.; Institute of Molecular and Cell Biology, Singapore.; SingHealth/Duke-NUS Institute of Precision Medicine, National Heart Centre Singapore, Singapore.; Department of Physiology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore., Tan P; Cancer and Stem Cell Biology Program, Duke-NUS Medical School, Singapore.; Cancer Therapeutics and Stratified Oncology, Genome Institute of Singapore, Singapore.; Cancer Science Institute of Singapore, National University of Singapore, Singapore.; SingHealth/Duke-NUS Institute of Precision Medicine, National Heart Centre Singapore, Singapore.; Cellular and Molecular Research, National Cancer Centre, Singapore.; Singapore Gastric Cancer Consortium, Singapore.; Biomedical Research Council, Agency for Science, Technology and Research, Singapore.

Publikováno v: The Journal of clinical investigation [J Clin Invest] 2020 Jun 01; Vol. 130 (6), pp. 3005-3020.