Improving biophysical properties of a bispecific antibody scaffold to aid developability: quality by molecular design.

Autor: Von Kreudenstein TS; Zymeworks Inc.; Vancouver, BC Canada., Escobar-Carbrera E, Lario PI, D'Angelo I, Brault K, Kelly J, Durocher Y, Baardsnes J, Woods RJ, Xie MH, Girod PA, Suits MD, Boulanger MJ, Poon DK, Ng GY, Dixit SB

Publikováno v: MAbs [MAbs] 2013 Sep-Oct; Vol. 5 (5), pp. 646-54. Date of Electronic Publication: 2013 Jul 08.

NMR spectroscopic characterization of a beta-(1,4)-glycosidase along its reaction pathway: stabilization upon formation of the glycosyl-enzyme intermediate.

Autor: Poon DK; Department of Biochemistry and Molecular Biology, Department of Chemistry, The Protein Engineering Network of Centres of Excellence, and The Michael Smith Laboratory, University of British Columbia, Vancouver, British Columbia, Canada V6T 1Z3., Ludwiczek ML, Schubert M, Kwan EM, Withers SG, McIntosh LP

Publikováno v: Biochemistry [Biochemistry] 2007 Feb 20; Vol. 46 (7), pp. 1759-70. Date of Electronic Publication: 2007 Jan 25.

Gas phase noncovalent protein complexes that retain solution binding properties: Binding of xylobiose inhibitors to the beta-1, 4 exoglucanase from cellulomonas fimi.

Autor: Tesić M; Department of Chemistry, University of British Columbia, Vancouver, British Columbia, Canada., Wicki J, Poon DK, Withers SG, Douglas DJ

Publikováno v: Journal of the American Society for Mass Spectrometry [J Am Soc Mass Spectrom] 2007 Jan; Vol. 18 (1), pp. 64-73. Date of Electronic Publication: 2006 Sep 26.

Characterizing the pH-dependent stability and catalytic mechanism of the family 11 xylanase from the alkalophilic Bacillus agaradhaerens.

Autor: Poon DK; The Department of Chemistry, University of British Columbia, BC, V6T 1Z1, Vancouver, Canada., Webster P, Withers SG, McIntosh LP

Publikováno v: Carbohydrate research [Carbohydr Res] 2003 Feb 14; Vol. 338 (5), pp. 415-21.