Výsledky vyhledávání - "Pooja Singhmar"

Akademický článek

Bexarotene normalizes chemotherapy-induced myelin decompaction and reverses cognitive and sensorimotor deficits in mice

Autor: Angie C. A. Chiang, Alexandre V. Seua, Pooja Singhmar, Luis D. Arroyo, Rajasekaran Mahalingam, Jian Hu, Annemieke Kavelaars, Cobi J. Heijnen

Publikováno v: Acta Neuropathologica Communications, Vol 8, Iss 1, Pp 1-15 (2020)

Abstract Frequently reported neurotoxic sequelae of cancer treatment include cognitive deficits and sensorimotor abnormalities that have long-lasting negative effects on the quality of life of an increasing number of cancer survivors. The underlying

Externí odkaz: https://doaj.org/article/033168cd016a49eb8c3097d800f1b85f

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Akademický článek

Angelman syndrome protein UBE3A interacts with primary microcephaly protein ASPM, localizes to centrosomes and regulates chromosome segregation.

Autor: Pooja Singhmar, Arun Kumar

Publikováno v: PLoS ONE, Vol 6, Iss 5, p e20397 (2011)

Many proteins associated with the phenotype microcephaly have been localized to the centrosome or linked to it functionally. All the seven autosomal recessive primary microcephaly (MCPH) proteins localize at the centrosome. Microcephalic osteodysplas

Externí odkaz: https://doaj.org/article/c35bf980f0314af5a73a205991785518

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Bexarotene normalizes chemotherapy-induced myelin decompaction and reverses cognitive and sensorimotor deficits in mice

Autor: Annemieke Kavelaars, Pooja Singhmar, Luis D. Arroyo, Jian Hu, Cobi J. Heijnen, Rajasekaran Mahalingam, Alexandre V. Seua, Angie C.A. Chiang

Publikováno v: Acta Neuropathologica Communications, Vol 8, Iss 1, Pp 1-15 (2020)
Acta Neuropathologica Communications

Frequently reported neurotoxic sequelae of cancer treatment include cognitive deficits and sensorimotor abnormalities that have long-lasting negative effects on the quality of life of an increasing number of cancer survivors. The underlying mechanism

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b06ed3ba9a0e7d4b0d6696b8216514c9
http://link.springer.com/article/10.1186/s40478-020-01061-x

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The fibroblast-derived protein PI16 controls neuropathic pain

Autor: Pooja Singhmar, Ronnie The Phong Trinh, Jiacheng Ma, XiaoJiao Huo, Bo Peng, Cobi J. Heijnen, Annemieke Kavelaars

Publikováno v: Proc Natl Acad Sci U S A

Chronic pain is a major clinical problem of which the mechanisms are incompletely understood. Here, we describe the concept that PI16, a protein of unknown function mainly produced by fibroblasts, controls neuropathic pain. The spared nerve injury (S

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c4c1be5bfa576cb0a229273fe53fb9cd
https://doi.org/10.1073/pnas.1913444117

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Corrigendum to 'TTI-101: A competitive inhibitor of STAT3 that spares oxidative phosphorylation and reverses mechanical allodynia in mouse models of neuropathic pain' [Biochem. Pharmacol. 192 (2021) 114688]

Autor: Moses M. Kasembeli, Pooja Singhmar, Jiacheng Ma, Jules Edralin, Yongfu Tang, Clydell Adams, Cobi J. Heijnen, Annemieke Kavelaars, David J. Tweardy

Publikováno v: Biochemical Pharmacology. 195:114860

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::39f788019ad593fbbe3108051deecec6
https://doi.org/10.1016/j.bcp.2021.114860

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Orally active Epac inhibitor reverses mechanical allodynia and loss of intraepidermal nerve fibers in a mouse model of chemotherapy-induced peripheral neuropathy

Autor: Pooja Singhmar, Fang C Mei, Annemieke Kavelaars, Yan Li, Xiao Jiao Huo, Xiaodong Cheng, Patrick M. Dougherty, Cobi J. Heijnen

Publikováno v: Pain. 159:884-893

Chemotherapy-induced peripheral neuropathy (CIPN) is a major side effect of cancer treatment that significantly compromises quality of life of cancer patients and survivors. Identification of targets for pharmacological intervention to prevent or rev

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1adc9a8825336617c7c9db91dc69a32c
https://doi.org/10.1097/j.pain.0000000000001160

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TTI-101: A competitive inhibitor of STAT3 that spares oxidative phosphorylation and reverses mechanical allodynia in mouse models of neuropathic pain

Autor: Pooja Singhmar, Jules D. Edralin, Yongfu Tang, Jiacheng Ma, Annemieke Kavelaars, Clydell Adams, Moses M. Kasembeli, David J. Tweardy, Cobi J. Heijnen

Publikováno v: Biochemical pharmacology
Biochem Pharmacol

Signal Transducer and Activator of Transcription (STAT) 3 emerged rapidly as a high-value target for treatment of cancer. However, small-molecule STAT3 inhibitors have been slow to enter the clinic due, in part, to serious adverse events (SAE), inclu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2aa807068e2e1093abb446c312997d19
https://doi.org/10.1016/j.bcp.2021.114688

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Epac1 interacts with importin β1 and controls neurite outgrowth independently of cAMP and Rap1

Autor: Annemieke Kavelaars, Xiaodong Cheng, Yong Zhou, John F. Hancock, Faiza Baameur, Cobi Jacoba Johanna Heijnen, Pooja Singhmar

Publikováno v: Scientific Reports

Exchange protein directly activated by cAMP-1 (Epac1) is a cAMP sensor that regulates multiple cellular functions including cellular migration, proliferation and differentiation. Classically, Epac1 is thought to exert its effects through binding of c

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b8fa354f4cf4033e0f4ccf2e1e59dd59
https://doi.org/10.1038/srep36370

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Critical role for Epac1 in inflammatory pain controlled by GRK2-mediated phosphorylation of Epac1

Autor: Annemieke Kavelaars, Xiao Jiao Huo, Federico Mayor, Susana Rojo Berciano, Cristina Murga, Yingmin Zhu, Niels Eijkelkamp, Pooja Singhmar, Fang C Mei, Cobi J. Heijnen, David H. Hawke, Xiaodong Cheng, Faiza Baameur

Publikováno v: Biblos-e Archivo. Repositorio Institucional de la UAM
instname
Digital.CSIC. Repositorio Institucional del CSIC
Repositorio Institucional de la Consejería de Sanidad de la Comunidad de Madrid
Consejería de Sanidad de la Comunidad de Madrid
Proceedings of the National Academy of Sciences of the United States of America, 113(11), 3036

cAMP signaling plays a key role in regulating pain sensitivity. Here, we uncover a previously unidentified molecular mechanism in which direct phosphorylation of the exchange protein directly activated by cAMP 1 (EPAC1) by G protein kinase 2 (GRK2) s

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dcc2e7c9128b2510c87b077c949f7ed2
https://dspace.library.uu.nl/handle/1874/333959

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