DNA methylation signature of chronic low-grade inflammation and its role in cardio-respiratory diseases

Autor: Matthias Wielscher, Pooja R. Mandaviya, Brigitte Kuehnel, Roby Joehanes, Rima Mustafa, Oliver Robinson, Yan Zhang, Barbara Bodinier, Esther Walton, Pashupati P. Mishra, Pascal Schlosser, Rory Wilson, Pei-Chien Tsai, Saranya Palaniswamy, Riccardo E. Marioni, Giovanni Fiorito, Giovanni Cugliari, Ville Karhunen, Mohsen Ghanbari, Bruce M. Psaty, Marie Loh, Joshua C. Bis, Benjamin Lehne, Nona Sotoodehnia, Ian J. Deary, Marc Chadeau-Hyam, Jennifer A. Brody, Alexia Cardona, Elizabeth Selvin, Alicia K. Smith, Andrew H. Miller, Mylin A. Torres, Eirini Marouli, Xin Gào, Joyce B. J. van Meurs, Johanna Graf-Schindler, Wolfgang Rathmann, Wolfgang Koenig, Annette Peters, Wolfgang Weninger, Matthias Farlik, Tao Zhang, Wei Chen, Yujing Xia, Alexander Teumer, Matthias Nauck, Hans J. Grabe, Macus Doerr, Terho Lehtimäki, Weihua Guan, Lili Milani, Toshiko Tanaka, Krista Fisher, Lindsay L. Waite, Silva Kasela, Paolo Vineis, Niek Verweij, Pim van der Harst, Licia Iacoviello, Carlotta Sacerdote, Salvatore Panico, Vittorio Krogh, Rosario Tumino, Evangelia Tzala, Giuseppe Matullo, Mikko A. Hurme, Olli T. Raitakari, Elena Colicino, Andrea A. Baccarelli, Mika Kähönen, Karl-Heinz Herzig, Shengxu Li, BIOS consortium, Karen N. Conneely, Jaspal S. Kooner, Anna Köttgen, Bastiaan T. Heijmans, Panos Deloukas, Caroline Relton, Ken K. Ong, Jordana T. Bell, Eric Boerwinkle, Paul Elliott, Hermann Brenner, Marian Beekman, Daniel Levy, Melanie Waldenberger, John C. Chambers, Abbas Dehghan, Marjo-Riitta Järvelin

Publikováno v: Nature Communications, Vol 13, Iss 1, Pp 1-14 (2022)

Chronic inflammation, marked by C-reactive protein, has been associated with changes in methylation, but the causal relationship is unclear. Here, the authors perform a Epigenome-wide association meta-analysis for C-reactive protein levels and find t

Externí odkaz: https://doaj.org/article/715a1a2d6b1f44f19a7bcf745876ed05

An integrative cross-omics analysis of DNA methylation sites of glucose and insulin homeostasis

Autor: Jun Liu, Elena Carnero-Montoro, Jenny van Dongen, Samantha Lent, Ivana Nedeljkovic, Symen Ligthart, Pei-Chien Tsai, Tiphaine C. Martin, Pooja R. Mandaviya, Rick Jansen, Marjolein J. Peters, Liesbeth Duijts, Vincent W. V. Jaddoe, Henning Tiemeier, Janine F. Felix, Gonneke Willemsen, Eco J. C. de Geus, Audrey Y. Chu, Daniel Levy, Shih-Jen Hwang, Jan Bressler, Rahul Gondalia, Elias L. Salfati, Christian Herder, Bertha A. Hidalgo, Toshiko Tanaka, Ann Zenobia Moore, Rozenn N. Lemaitre, Min A Jhun, Jennifer A. Smith, Nona Sotoodehnia, Stefania Bandinelli, Luigi Ferrucci, Donna K. Arnett, Harald Grallert, Themistocles L. Assimes, Lifang Hou, Andrea Baccarelli, Eric A. Whitsel, Ko Willems van Dijk, Najaf Amin, André G. Uitterlinden, Eric J. G. Sijbrands, Oscar H. Franco, Abbas Dehghan, Tim D. Spector, Josée Dupuis, Marie-France Hivert, Jerome I. Rotter, James B. Meigs, James S. Pankow, Joyce B. J. van Meurs, Aaron Isaacs, Dorret I. Boomsma, Jordana T. Bell, Ayşe Demirkan, Cornelia M. van Duijn

Publikováno v: Nature Communications, Vol 10, Iss 1, Pp 1-11 (2019)

Our understanding of the functional link between differential DNA methylation and type 2 diabetes and obesity remains limited. Here the authors present a blood-based EWAS of fasting glucose and insulin among 4808 non-diabetic Europeans and identify n

Externí odkaz: https://doaj.org/article/19891659495247948d3d723f24545ddd

Differentially methylated regions in T cells identify kidney transplant patients at risk for de novo skin cancer

Autor: Fleur S. Peters, Annemiek M. A. Peeters, Pooja R. Mandaviya, Joyce B. J. van Meurs, Leo J. Hofland, Jacqueline van de Wetering, Michiel G. H. Betjes, Carla C. Baan, Karin Boer

Publikováno v: Clinical Epigenetics, Vol 10, Iss 1, Pp 1-11 (2018)

Abstract Background Cutaneous squamous cell carcinoma (cSCC) occurs 65–200 times more in immunosuppressed organ transplant patients than in the general population. T cells, which are targeted by the given immunosuppressive drugs, are involved in an

Externí odkaz: https://doaj.org/article/d94efa70bb4f40a79c4873b34ffbc533

Interaction between plasma homocysteine and the MTHFR c.677C > T polymorphism is associated with site-specific changes in DNA methylation in humans

Autor: Marie-Joe Dib, Joyce B. J. van Meurs, André G. Uitterlinden, Alexander J Nash, Pooja R. Mandaviya, Toby Andrew, Kourosh R. Ahmadi, Sandra G. Heil

Publikováno v: FASEB Journal, 33(1), 833-843. FASEB
Faseb Journal, 33(1), 833-843. FASEB

One-carbon metabolism provides a direct link among dietary folate/vitamin B-12 exposure, the activity of the enzyme methylenetetrahydrofolate reductase (MTHFR), and epigenetic regulation of the genome via DNA methylation. Previously, it has been show

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8242d5b41f147953ff86213728d6ee2a
https://doi.org/10.1096/fj.201800400r

Genomic and phenotypic insights from an atlas of genetic effects on DNA methylation

Autor: Giuseppe Matullo, John R. B. Perry, Meena Kumari, Gemma C Sharp, Tomáš Paus, E. Giralt-Steinhauer, Marta E. Alarcón-Riquelme, Koen F. Dekkers, F. Gagnon, Simonetta Guarrera, Cilla Söderhäll, Rosie M. Walker, Therese Tillin, M. Smarts, Juan E. Castillo-Fernandez, John M. Starr, Jean Shin, Dan Mason, T Esko, Christopher Shaw, Hannah R Elliott, Manon Bernard, David L. Corcoran, Yvonne Awaloff, Ahmad Al Khleifat, Bert Brunekreef, Clara Viberti, John Wright, Gibran Hemani, Kathryn L. Evans, Camilla Schmidt Morgen, Jouke J. Hottenga, Susan M. Ring, Terrie E. Moffitt, Silva Kasela, C. Hale, Idil Yet, Katri Räikkönen, René Luijk, Vanessa Schmoll, Kimberley Burrows, Annelot M. Dekker, D. VanHeemst, Jordana T. Bell, Jordi Jimenez-Conde, Carlotta Sacerdote, Salvatore Panico, Lili Milani, Nabila Kazmi, Torben Hansen, Aleksey Shatunov, J L Min, Richa Gupta, Henning Tiemeier, Grant W. Montgomery, Vincent W. V. Jaddoe, E.J.C. de Geus, Fernando Rivadeneira, Debbie A Lawlor, Carol A. Wang, Toni-Kim Clarke, Susanne Lucae, Nicholas J. Wareham, Jordi Sunyer, Felix R. Day, C. Soriano-Tarraga, Christoph Bock, Juan R. González, D. Aissi, J.B. van Meurs, Ian J. Deary, Ken K. Ong, Louise Arseneault, Eilis Hannon, Bastiaan T. Heijmans, Philip E. Melton, Ashok Kumar, Pierre-Emmanuel Morange, Zdenka Pausova, T.D. Spector, Nicholas G. Martin, J. Mill, Francesc Català-Moll, Alun D. Hughes, Leonard C. Schalkwyk, Giovanni Cugliari, Carlos Ruiz-Arenas, Elena Carnero-Montoro, Marine Germain, Yanni Zeng, Andrew M. McIntosh, Riccardo E. Marioni, Wilfried Karmaus, Ikram, Gonneke Willemsen, Miina Ollikainen, Karen M Ho, Craig E. Pennell, F.I. Rezwan, Darina Czamara, Ramona A. J. Zwamborn, Dorret I. Boomsma, Wendy L. McArdle, J. M. van Dongen, Guillermo Barturen, Matthew Suderman, Richie Poulton, Daniel Lawson, A. Metspalu, David-Alexandre Trégouët, Marian Beekman, Andrew D. Bretherick, Johanna Klughammer, Hongmei Zhang, M.H. van IJzendoorn, Nish Chaturvedi, Jari Lahti, Karen Sugden, Jan H. Veldink, Mariona Bustamante, Avshalom Caspi, Pooja R. Mandaviya, Judith M. Vonk, Tom R. Gaunt, Cheng-Jian Xu, John W. Holloway, Tian Lin, Tom G. Richardson, Caroline L Relton, Naomi R. Wray, Allan F. McRae, George Davey Smith, Erik Melén, Valentina Iotchkova, Ellen A. Nohr, Jaakko Kaprio, Göran Pershagen, Elisabeth B. Binder, A. al Chalabi, T.J. Gorrie-Stone, K. van Eijk, Gerard H. Koppelman, M. Lerro, Alexia Cardona, Sailalitha Bollepalli, P.E. Slagboom, Thorkild I. A. Sørensen, André G. Uitterlinden, Jaume Roquer, Peter M. Visscher, Janine F. Felix, Martin Kerick, Gail Davies, Rae-Chi Huang, Alfredo Iacoangeli, Alison D. Murray

Publikováno v: Nature Genetics
Digital.CSIC. Repositorio Institucional del CSIC
instname
Nature genetics, 53(9), 1311-1321. Nature Publishing Group
Nature Genetics, 53, 1311-1321. Nature Publishing Group
Nature Genetics, Nature Publishing Group, 2021, 53 (9), pp.1311-1321. ⟨10.1038/s41588-021-00923-x⟩
et al., Min, J L, Hemani, G, Hannon, E, dekkers, K, Castillo-Fernandez, J, Luijk, R, Carnero-Montoro, E, Lawson, D J, Burrows, K, Suderman, M J, Bretherick, A D, Richardson, T G, Klughammer, J, Lochkova, V, Sharp, G C, Al Khleifat, A, Shatunov, A, Lacoangeli, A, Mcardle, W L, Ho, K M, Kumar, A, Soderhall, C, Soriano-Tárraga, C, Giralt-Steinhauer, E, Kazmi, N, Mason, D, McRae, A F, Corcoran, D L, Elliott, H R, Ring, S M, Lawlor, D A, Sørensen, T I A, Davey Smith, G, Gaunt, T R & Relton, C L 2021, ' Genomic and phenotypic insights from an atlas of genetic effects on DNA methylation ', Nature Genetics, vol. 53, no. 9, pp. 1311-1321 . https://doi.org/10.1038/s41588-021-00923-x
Min, J L, Hemani, G, Hannon, E, Dekkers, K F, Castillo-Fernandez, J, Luijk, R, Carnero-Montoro, E, Lawson, D J, Burrows, K, Suderman, M, Bretherick, A D, Richardson, T G, Klughammer, J, Iotchkova, V, Sharp, G, Al Khleifat, A, Shatunov, A, Iacoangeli, A, McArdle, W L, Ho, K M, Kumar, A, Söderhäll, C, Soriano-Tárraga, C, Giralt-Steinhauer, E, Kazmi, N, Mason, D, McRae, A F, Corcoran, D L, Sugden, K, Kasela, S, Cardona, A, Day, F R, Cugliari, G, Viberti, C, Guarrera, S, Lerro, M, Gupta, R, Bollepalli, S, Mandaviya, P, Zeng, Y, Clarke, T K, Walker, R M, Schmoll, V, Czamara, D, Ruiz-Arenas, C, Elliott, H R, Nohr, E A, Sørensen, T I A, Hansen, T, Morgen, C S & BIOS Consortium 2021, ' Genomic and phenotypic insights from an atlas of genetic effects on DNA methylation ', Nature Genetics, vol. 53, no. 9, pp. 1311-1321 . https://doi.org/10.1038/s41588-021-00923-x
Min, J L, van Dongen, J, Hottenga, J J, Willemsen, G, de Geus, E J C, Boomsma, D I, Relton, C L & BIOS Consortium 2021, ' Genomic and phenotypic insights from an atlas of genetic effects on DNA methylation ', Nature genetics, vol. 53, no. 9, pp. 1311-1321 . https://doi.org/10.1038/s41588-021-00923-x
Min, J L, Hemani, G, Hannon, E, Dekkers, K F, Castillo-Fernandez, J, Luijk, R, Carnero-Montoro, E, Lawson, D J, Burrows, K, Suderman, M, Bretherick, A D, Richardson, T G, Klughammer, J, Iotchkova, V, Sharp, G, Al Khleifat, A, Shatunov, A, Iacoangeli, A, McArdle, W L, Ho, K M, Kumar, A, Söderhäll, C, Soriano-Tárraga, C, Giralt-Steinhauer, E, Kazmi, N, Mason, D, McRae, A F, Corcoran, D L, Sugden, K, Kasela, S, Cardona, A, Day, F R, Cugliari, G, Viberti, C, Guarrera, S, Lerro, M, Gupta, R, Bollepalli, S, Mandaviya, P, Zeng, Y, Clarke, T K, Walker, R M, Schmoll, V, Czamara, D, Ruiz-Arenas, C, Rezwan, F I, Marioni, R E, Nohr, E A, Sørensen, T I A, Morgen, C S & BIOS Consortium 2021, ' Genomic and phenotypic insights from an atlas of genetic effects on DNA methylation ', Nature Genetics, vol. 53, no. 9, pp. 1311-1321 . https://doi.org/10.1038/s41588-021-00923-x
Nature Genetics, 53(9), 1311-1321. NATURE PORTFOLIO
Nature Genetics, 2021, 53 (9), pp.1311-1321. ⟨10.1038/s41588-021-00923-x⟩
Nature Genetics, 53(9), 1311-1321. Nature Publishing Group

DNA methylation quantitative trait locus (mQTL) analyses on 32,851 participants identify genetic variants associated with DNA methylation at 420,509 sites in blood, resulting in a database of >270,000 independent mQTLs. Characterizing genetic influen

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c9f18b02f6a59803fa5fa39c1daf1e4d
https://pubmed.ncbi.nlm.nih.gov/34493871