Epigenome wide association study of response to methotrexate in early rheumatoid arthritis patients.

Autor: Helen R Gosselt, Costanza L Vallerga, Pooja R Mandaviya, Erik Lubberts, Johanna M W Hazes, Robert de Jonge, Sandra G Heil

Publikováno v: PLoS ONE, Vol 16, Iss 3, p e0247709 (2021)

AimTo identify differentially methylated positions (DMPs) and regions (DMRs) that predict response to Methotrexate (MTX) in early rheumatoid arthritis (RA) patients.Materials and methodsDNA from baseline peripheral blood mononuclear cells was extract

Externí odkaz: https://doaj.org/article/736434ab899447cabb519e42f9e12903

Altered DNA methylation in children born to mothers with rheumatoid arthritis during pregnancy

Autor: Johanna M. W. Hazes, Radboud J E M Dolhain, Janine F. Felix, Pooja R. Mandaviya, Liesbeth Duijts, Joyce B. J. van Meurs, Hilal Ince-Askan

Publikováno v: Annals of the Rheumatic Diseases, 78(9), 1198-1204. BMJ Publishing Group
Annals of the Rheumatic Diseases

ObjectivesThe main objective of this study was to determine whether the DNA methylation profile of children born to mothers with rheumatoid arthritis (RA) is different from that of children born to mothers from the general population. In addition, we

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f530ee0e4d091b2d0f24d3ff6b2f3ede
https://pure.eur.nl/en/publications/8c8c39f6-bc6c-425d-9856-2bacb632453d

Association of maternal prenatal smoking GFI1-locus and cardio-metabolic phenotypes in 18,212 adultsResearch in context

Autor: Priyanka Parmar, Estelle Lowry, Giovanni Cugliari, Matthew Suderman, Rory Wilson, Ville Karhunen, Toby Andrew, Petri Wiklund, Matthias Wielscher, Simonetta Guarrera, Alexander Teumer, Benjamin Lehne, Lili Milani, Niek de Klein, Pashupati P. Mishra, Phillip E. Melton, Pooja R. Mandaviya, Silva Kasela, Jana Nano, Weihua Zhang, Yan Zhang, Andre G. Uitterlinden, Annette Peters, Ben Schöttker, Christian Gieger, Denise Anderson, Dorret I. Boomsma, Hans J. Grabe, Salvatore Panico, Jan H. Veldink, Joyce B.J. van Meurs, Leonard van den Berg, Lawrence J. Beilin, Lude Franke, Marie Loh, Marleen M.J. van Greevenbroek, Matthias Nauck, Mika Kähönen, Mikko A. Hurme, Olli T. Raitakari, Oscar H. Franco, P.Eline Slagboom, Pim van der Harst, Sonja Kunze, Stephan B. Felix, Tao Zhang, Wei Chen, Trevor A. Mori, Amelie Bonnefond, Bastiaan T. Heijmans, Taulant Muka, Jaspal S. Kooner, Krista Fischer, Melanie Waldenberger, Philippe Froguel, Rae-Chi Huang, Terho Lehtimäki, Wolfgang Rathmann, Caroline L. Relton, Giuseppe Matullo, Hermann Brenner, Niek Verweij, Shengxu Li, John C. Chambers, Marjo-Riitta Järvelin, Sylvain Sebert

Publikováno v: EBioMedicine, Vol 38, Iss, Pp 206-216 (2018)

Background: DNA methylation at the GFI1-locus has been repeatedly associated with exposure to smoking from the foetal period onwards. We explored whether DNA methylation may be a mechanism that links exposure to maternal prenatal smoking with offspri

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doajarticles::af76fa2aa532bfaf4a57a2128b227fe7
http://www.sciencedirect.com/science/article/pii/S2352396418304870

Genomic and phenotypic insights from an atlas of genetic effects on DNA methylation

Autor: Giuseppe Matullo, John R. B. Perry, Meena Kumari, Gemma C Sharp, Tomáš Paus, E. Giralt-Steinhauer, Marta E. Alarcón-Riquelme, Koen F. Dekkers, F. Gagnon, Simonetta Guarrera, Cilla Söderhäll, Rosie M. Walker, Therese Tillin, M. Smarts, Juan E. Castillo-Fernandez, John M. Starr, Jean Shin, Dan Mason, T Esko, Christopher Shaw, Hannah R Elliott, Manon Bernard, David L. Corcoran, Yvonne Awaloff, Ahmad Al Khleifat, Bert Brunekreef, Clara Viberti, John Wright, Gibran Hemani, Kathryn L. Evans, Camilla Schmidt Morgen, Jouke J. Hottenga, Susan M. Ring, Terrie E. Moffitt, Silva Kasela, C. Hale, Idil Yet, Katri Räikkönen, René Luijk, Vanessa Schmoll, Kimberley Burrows, Annelot M. Dekker, D. VanHeemst, Jordana T. Bell, Jordi Jimenez-Conde, Carlotta Sacerdote, Salvatore Panico, Lili Milani, Nabila Kazmi, Torben Hansen, Aleksey Shatunov, J L Min, Richa Gupta, Henning Tiemeier, Grant W. Montgomery, Vincent W. V. Jaddoe, E.J.C. de Geus, Fernando Rivadeneira, Debbie A Lawlor, Carol A. Wang, Toni-Kim Clarke, Susanne Lucae, Nicholas J. Wareham, Jordi Sunyer, Felix R. Day, C. Soriano-Tarraga, Christoph Bock, Juan R. González, D. Aissi, J.B. van Meurs, Ian J. Deary, Ken K. Ong, Louise Arseneault, Eilis Hannon, Bastiaan T. Heijmans, Philip E. Melton, Ashok Kumar, Pierre-Emmanuel Morange, Zdenka Pausova, T.D. Spector, Nicholas G. Martin, J. Mill, Francesc Català-Moll, Alun D. Hughes, Leonard C. Schalkwyk, Giovanni Cugliari, Carlos Ruiz-Arenas, Elena Carnero-Montoro, Marine Germain, Yanni Zeng, Andrew M. McIntosh, Riccardo E. Marioni, Wilfried Karmaus, Ikram, Gonneke Willemsen, Miina Ollikainen, Karen M Ho, Craig E. Pennell, F.I. Rezwan, Darina Czamara, Ramona A. J. Zwamborn, Dorret I. Boomsma, Wendy L. McArdle, J. M. van Dongen, Guillermo Barturen, Matthew Suderman, Richie Poulton, Daniel Lawson, A. Metspalu, David-Alexandre Trégouët, Marian Beekman, Andrew D. Bretherick, Johanna Klughammer, Hongmei Zhang, M.H. van IJzendoorn, Nish Chaturvedi, Jari Lahti, Karen Sugden, Jan H. Veldink, Mariona Bustamante, Avshalom Caspi, Pooja R. Mandaviya, Judith M. Vonk, Tom R. Gaunt, Cheng-Jian Xu, John W. Holloway, Tian Lin, Tom G. Richardson, Caroline L Relton, Naomi R. Wray, Allan F. McRae, George Davey Smith, Erik Melén, Valentina Iotchkova, Ellen A. Nohr, Jaakko Kaprio, Göran Pershagen, Elisabeth B. Binder, A. al Chalabi, T.J. Gorrie-Stone, K. van Eijk, Gerard H. Koppelman, M. Lerro, Alexia Cardona, Sailalitha Bollepalli, P.E. Slagboom, Thorkild I. A. Sørensen, André G. Uitterlinden, Jaume Roquer, Peter M. Visscher, Janine F. Felix, Martin Kerick, Gail Davies, Rae-Chi Huang, Alfredo Iacoangeli, Alison D. Murray

Publikováno v: Nature Genetics
Digital.CSIC. Repositorio Institucional del CSIC
instname
Nature genetics, 53(9), 1311-1321. Nature Publishing Group
Nature Genetics, 53, 1311-1321. Nature Publishing Group
Nature Genetics, Nature Publishing Group, 2021, 53 (9), pp.1311-1321. ⟨10.1038/s41588-021-00923-x⟩
et al., Min, J L, Hemani, G, Hannon, E, dekkers, K, Castillo-Fernandez, J, Luijk, R, Carnero-Montoro, E, Lawson, D J, Burrows, K, Suderman, M J, Bretherick, A D, Richardson, T G, Klughammer, J, Lochkova, V, Sharp, G C, Al Khleifat, A, Shatunov, A, Lacoangeli, A, Mcardle, W L, Ho, K M, Kumar, A, Soderhall, C, Soriano-Tárraga, C, Giralt-Steinhauer, E, Kazmi, N, Mason, D, McRae, A F, Corcoran, D L, Elliott, H R, Ring, S M, Lawlor, D A, Sørensen, T I A, Davey Smith, G, Gaunt, T R & Relton, C L 2021, ' Genomic and phenotypic insights from an atlas of genetic effects on DNA methylation ', Nature Genetics, vol. 53, no. 9, pp. 1311-1321 . https://doi.org/10.1038/s41588-021-00923-x
Min, J L, Hemani, G, Hannon, E, Dekkers, K F, Castillo-Fernandez, J, Luijk, R, Carnero-Montoro, E, Lawson, D J, Burrows, K, Suderman, M, Bretherick, A D, Richardson, T G, Klughammer, J, Iotchkova, V, Sharp, G, Al Khleifat, A, Shatunov, A, Iacoangeli, A, McArdle, W L, Ho, K M, Kumar, A, Söderhäll, C, Soriano-Tárraga, C, Giralt-Steinhauer, E, Kazmi, N, Mason, D, McRae, A F, Corcoran, D L, Sugden, K, Kasela, S, Cardona, A, Day, F R, Cugliari, G, Viberti, C, Guarrera, S, Lerro, M, Gupta, R, Bollepalli, S, Mandaviya, P, Zeng, Y, Clarke, T K, Walker, R M, Schmoll, V, Czamara, D, Ruiz-Arenas, C, Elliott, H R, Nohr, E A, Sørensen, T I A, Hansen, T, Morgen, C S & BIOS Consortium 2021, ' Genomic and phenotypic insights from an atlas of genetic effects on DNA methylation ', Nature Genetics, vol. 53, no. 9, pp. 1311-1321 . https://doi.org/10.1038/s41588-021-00923-x
Min, J L, van Dongen, J, Hottenga, J J, Willemsen, G, de Geus, E J C, Boomsma, D I, Relton, C L & BIOS Consortium 2021, ' Genomic and phenotypic insights from an atlas of genetic effects on DNA methylation ', Nature genetics, vol. 53, no. 9, pp. 1311-1321 . https://doi.org/10.1038/s41588-021-00923-x
Min, J L, Hemani, G, Hannon, E, Dekkers, K F, Castillo-Fernandez, J, Luijk, R, Carnero-Montoro, E, Lawson, D J, Burrows, K, Suderman, M, Bretherick, A D, Richardson, T G, Klughammer, J, Iotchkova, V, Sharp, G, Al Khleifat, A, Shatunov, A, Iacoangeli, A, McArdle, W L, Ho, K M, Kumar, A, Söderhäll, C, Soriano-Tárraga, C, Giralt-Steinhauer, E, Kazmi, N, Mason, D, McRae, A F, Corcoran, D L, Sugden, K, Kasela, S, Cardona, A, Day, F R, Cugliari, G, Viberti, C, Guarrera, S, Lerro, M, Gupta, R, Bollepalli, S, Mandaviya, P, Zeng, Y, Clarke, T K, Walker, R M, Schmoll, V, Czamara, D, Ruiz-Arenas, C, Rezwan, F I, Marioni, R E, Nohr, E A, Sørensen, T I A, Morgen, C S & BIOS Consortium 2021, ' Genomic and phenotypic insights from an atlas of genetic effects on DNA methylation ', Nature Genetics, vol. 53, no. 9, pp. 1311-1321 . https://doi.org/10.1038/s41588-021-00923-x
Nature Genetics, 53(9), 1311-1321. NATURE PORTFOLIO
Nature Genetics, 2021, 53 (9), pp.1311-1321. ⟨10.1038/s41588-021-00923-x⟩
Nature Genetics, 53(9), 1311-1321. Nature Publishing Group

DNA methylation quantitative trait locus (mQTL) analyses on 32,851 participants identify genetic variants associated with DNA methylation at 420,509 sites in blood, resulting in a database of >270,000 independent mQTLs. Characterizing genetic influen

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c9f18b02f6a59803fa5fa39c1daf1e4d
https://pubmed.ncbi.nlm.nih.gov/34493871

Differentially methylated regions in T cells identify kidney transplant patients at risk for de novo skin cancer

Autor: Leo J. Hofland, Michiel G. H. Betjes, Fleur S. Peters, Jacqueline van de Wetering, Carla C. Baan, Joyce B. J. van Meurs, Karin Boer, Annemiek M.A. Peeters, Pooja R. Mandaviya

Publikováno v: Clinical Epigenetics, Vol 10, Iss 1, Pp 1-11 (2018)
Clinical Epigenetics, 10:81. BioMed Central Ltd.
Clinical epigenetics, 10:81. BioMed Central Ltd
Clinical Epigenetics

Background Cutaneous squamous cell carcinoma (cSCC) occurs 65–200 times more in immunosuppressed organ transplant patients than in the general population. T cells, which are targeted by the given immunosuppressive drugs, are involved in anti-tumor

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ad2907e692409c94acae12774607e73f
http://link.springer.com/article/10.1186/s13148-018-0519-7