Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Pooja Chandna"'
Publikováno v:
Pharmaceutical Research. 27:2296-2306
In order to improve drug delivery to drug-resistant ovarian tumors, we constructed a multifunctional polymer-peptide-drug conjugate (PPDC) system for effective treatment of primary and metastatic ovarian cancers.The PPDC consists of the poly(Ethylene
Publikováno v:
Journal of Pharmacology and Experimental Therapeutics. 316:992-998
Chemotherapeutic agents are known to induce programmed cell death or apoptosis. The activation of cellular antiapoptotic defense that prevents the translation of drug-induced damage into cell death is the key factor in cellular antiapoptotic resistan
Autor:
Mahesh L. Patil, Oleh Taratula, Min Zhang, Tamara Minko, Pooja Chandna, Jayant Khandare, Maha Saad
Publikováno v:
Methods in Molecular Biology ISBN: 9781607616085
Synthesis and evaluation of a novel cancer cell's receptor-targeted internally quaternized and surface neutral poly(amidoamine) (PAMAM) generation four dendrimer as well as PAMAM-paclitaxel conjugate are described. The advantages of developed nanocar
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::739773c499214b19038b8a905ebf0fec
https://doi.org/10.1007/978-1-60761-609-2_19
https://doi.org/10.1007/978-1-60761-609-2_19
Autor:
Tamara Minko, Vitaly P. Pozharov, Olga B. Garbuzenko, Maha Saad, Jayant Khandare, Elizabeth Ber, Pooja Chandna
To compare the influence of different characteristics of nanocarriers on the efficacy of chemotherapy and imaging, we designed, characterized, and evaluated three widely used nanocarriers: linear polymer, dendrimer and liposome in vitro and in vivo.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fe78609044cc5ea71266fcde68e7850b
https://europepmc.org/articles/PMC3590109/
https://europepmc.org/articles/PMC3590109/
Autor:
Tamara Minko, Alexandre A. Vetcher, Maha Saad, Jayant Khandare, Yang Wang, Elizabeth Ber, Pooja Chandna, Viatcheslav A. Soldatenkov
Publikováno v:
Molecular pharmaceutics. 4(5)
A novel targeted proapoptotic anticancer drug delivery system (DDS) was developed and evaluated both in vitro and in vivo. The system contains poly(ethylene glycol) polymer (PEG) as a carrier, camptothecin (CPT) as an anticancer drug/cell death induc
Autor:
Sreeja Jayant, Tamara Minko, Jayant Khandare, Nicholi Vorsa, Ajay P. Singh, Pooja Chandna, Yang Wang
Publikováno v:
Bioconjugate chemistry. 17(6)
The relative difference in polymeric architectures of dendrimer and linear bis(poly(ethylene glycol)) (PEG) polymer in conjugation with paclitaxel has been described. Paclitaxel, a poorly soluble anticancer drug, was covalently conjugated with PAMAM
Publikováno v:
The Journal of pharmacology and experimental therapeutics. 317(3)
We designed, synthesized, and evaluated in vitro and in vivo a novel targeted anticancer polymeric prodrug containing multiple copies of tumor targeting moiety [synthetic luteinizing hormone-releasing hormone (LHRH) peptide, analog of LHRH] and antic
Autor:
Stanley Stein, Patrick J. Sinko, Jayant Khandare, Yingzheng Wang, S. S. Dharap, Bo Qiu, Tamara Minko, A. Farmanfarmaian, Simi Gunaseelan, Pooja Chandna
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America. 102(36)
The central problem in cancer chemotherapy is the severe toxic side effects of anticancer drugs on healthy tissues. Invariably the side effects impose dose reduction, treatment delay, or discontinuance of therapy. To limit the adverse side effects of
Autor:
Virna Borowski, Zhihua Zhang, Yang Wang, Deshan Yu, Tamara Minko, Ping Peng, Hong Zhao, Gerrit Borchard, Pooja Chandna, Mary Mehlig, Karen Yang, David Filpula, S. S. Dharap
Publikováno v:
Journal of controlled release : official journal of the Controlled Release Society. 110(1)
Antitumor effect of poly(ethylene glycol)-camptothecin conjugate (PEG-CPT) was studied in the nude mouse model of human colon cancer xenografts. The animals were treated intravenously with 15 mg/kg of camptothecin (CPT) or PEG-CPT conjugate at equiva