Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Pooja, Srinivas"'
Autor:
Jeremy Monroe, Daniel E. Eyler, Lili Mitchell, Indrajit Deb, Abigail Bojanowski, Pooja Srinivas, Christine M. Dunham, Bijoyita Roy, Aaron T. Frank, Kristin S. Koutmou
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-11 (2024)
Abstract The ribosome utilizes hydrogen bonding between mRNA codons and aminoacyl-tRNAs to ensure rapid and accurate protein production. Chemical modification of mRNA nucleobases can adjust the strength and pattern of this hydrogen bonding to alter p
Externí odkaz:
https://doaj.org/article/50975c01401849b98fd36770145e907c
Autor:
Zachary D. Aron, Atousa Mehrani, Eric D. Hoffer, Kristie L. Connolly, Pooja Srinivas, Matthew C. Torhan, John N. Alumasa, Mynthia Cabrera, Divya Hosangadi, Jay S. Barbor, Steven C. Cardinale, Steven M. Kwasny, Lucas R. Morin, Michelle M. Butler, Timothy J. Opperman, Terry L. Bowlin, Ann Jerse, Scott M. Stagg, Christine M. Dunham, Kenneth C. Keiler
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-12 (2021)
Antibiotic-resistant bacterial pathogens pose a substantial threat to human health. Here, aided by structural analyses, the authors describe the molecular mechanism behind the activity of a series of compounds that inhibit trans-translation and are e
Externí odkaz:
https://doaj.org/article/65f0e506e42e4cd09c551a4db2d7e630
Autor:
Chetan Hasmukh Mehta, Poojary Pooja Srinivas, Anusha SB, Kirollos Bahaa Fathy Mahany, KB Koteshwara, Usha Yogendra Nayak
Publikováno v:
Research Journal of Pharmacy and Technology. :3709-3716
The present study is aimed at the design and development of aceclofenac co-crystals. Co-crystallization is one of the important techniques which helps to enhance the aqueous solubility of drugs by modifying the crystal structure using incorporation o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7e33c303017886ee65ed04da27df982c
https://doi.org/10.52711/0974-360x.2022.00622
https://doi.org/10.52711/0974-360x.2022.00622
Autor:
S. M. Basavarajaiah, G. Y. Nagesh, Mohammad Javeed, Rashmi Bhat, S. Nethravathi, Jeelan N. Basha, K. Ramakrishna Reddy, C. Nisarga, Pooja Srinivas
Publikováno v:
Molecular Diversity. 27:679-693
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e787538afe38f2eaf18cbb90675ac9c0
https://doi.org/10.1007/s11030-022-10448-y
https://doi.org/10.1007/s11030-022-10448-y
Autor:
Poojary Pooja Srinivas, Nishank Prabhu, Vasantharaju SG, Neel Patel, Aravind Pai, Vasudev Pai, Muddukrishna Badamane Sathyanarayana
Publikováno v:
RASAYAN Journal of Chemistry. 15:2417-2428
In this present study, a new co-crystal of azithromycin with nicotinamide and naringenin has been developed with improved solubility. Azithromycin is a class II drug with poor aqueous solubility; hence an attempt has been made to improve its solubili
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::fbc04c5d41c10b2a79746910a6d4fe9c
https://doi.org/10.31788/rjc.2022.1546985
https://doi.org/10.31788/rjc.2022.1546985
Autor:
Pooja Srinivas, Meisam Nosrati, Natalia Zelinskaya, Debayan Dey, Lindsay R. Comstock, Christine M. Dunham, Graeme L. Conn
Publikováno v:
bioRxiv
Acquired ribosomal RNA (rRNA) methylation has emerged as a significant mechanism of aminoglycoside resistance in pathogenic bacterial infections. Modification of a single nucleotide in the ribosome decoding center by the aminoglycoside-resistance 16S
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f36a7687d6663ee93546431136a6f16f
https://europepmc.org/articles/PMC10054953/
https://europepmc.org/articles/PMC10054953/
Publikováno v:
Bioessays
Bacteria use trans-translation to rescue stalled ribosomes and target incomplete proteins for proteolysis. Despite similarities between tRNAs and transfer-messenger RNA (tmRNA), the key molecule for trans-translation, new structural and biochemical d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a715a5c46d827bcdd8602200c388fecc
https://europepmc.org/articles/PMC9308750/
https://europepmc.org/articles/PMC9308750/
Autor:
Zane T, Laughlin, Suparno, Nandi, Debayan, Dey, Natalia, Zelinskaya, Marta A, Witek, Pooja, Srinivas, Ha An, Nguyen, Emily G, Kuiper, Lindsay R, Comstock, Christine M, Dunham, Graeme L, Conn
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America. 119(14)
Changes in bacterial ribosomal RNA (rRNA) methylation status can alter the activity of diverse groups of ribosome-targeting antibiotics. These modifications are typically incorporated by a single methyltransferase that acts on one nucleotide target a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::08fd42be2df7e73cd6d00fa51f067dd0
https://pubmed.ncbi.nlm.nih.gov/35357969
https://pubmed.ncbi.nlm.nih.gov/35357969
Autor:
Michael Ibba, Ian J Pavelich, Ricardo C. Guerrero-Ferreira, Pooja Srinivas, Christine M. Dunham, Puneet Juneja, Rebecca E. Steiner
Publikováno v:
Nucleic Acids Research
High fidelity during protein synthesis is accomplished by aminoacyl-tRNA synthetases (aaRSs). These enzymes ligate an amino acid to a cognate tRNA and have proofreading and editing capabilities that ensure high fidelity. Phenylalanyl-tRNA synthetase
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1ef967c81ab07d882b60f5498794d0a1
https://pubmed.ncbi.nlm.nih.gov/34581811
https://pubmed.ncbi.nlm.nih.gov/34581811
Autor:
Atousa Mehrani, Mynthia Cabrera, Kenneth C. Keiler, Michelle M. Butler, Steven M. Kwasny, Pooja Srinivas, Lucas R. Morin, Divya Hosangadi, John N. Alumasa, Jay S. Barbor, Steven C. Cardinale, Scott M. Stagg, Zachary D. Aron, Christine M. Dunham, Ann E. Jerse, Matthew C. Torhan, Timothy J. Opperman, Eric D. Hoffer, Terry L. Bowlin, Kristie L. Connolly
Publikováno v:
Nature Communications
Nature Communications, Vol 12, Iss 1, Pp 1-12 (2021)
Nature Communications, Vol 12, Iss 1, Pp 1-12 (2021)
Bacterial ribosome rescue pathways that remove ribosomes stalled on mRNAs during translation have been proposed as novel antibiotic targets because they are essential in bacteria and are not conserved in humans. We previously reported the discovery o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::411f83145a0e100fbdf1e585bbf3dfa6
https://doi.org/10.1038/s41467-021-22012-7
https://doi.org/10.1038/s41467-021-22012-7