Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Pontus Plaven-Sigray"'
Autor:
Gjertrud Louise Laurell, Pontus Plavén-Sigray, Claus Svarer, R. Todd Ogden, Gitte Moos Knudsen, Martin Schain
Publikováno v:
NeuroImage, Vol 263, Iss , Pp 119620- (2022)
Molecular neuroimaging is today considered essential for evaluation of novel CNS drugs; it is used to quantify blood-brain barrier permeability, verify interaction with key target and determine the drug dose resulting in 50% occupancy, IC50. In spite
Externí odkaz:
https://doaj.org/article/fb55ae1d3f5f487b9b947c6edd72b463
Autor:
Maria Lee, Helena Fatouros-Bergman, Pontus Plavén-Sigray, Pauliina Ikonen Victorsson, Carl M. Sellgren, Sophie Erhardt, Lena Flyckt, Lars Farde, Simon Cervenka
Publikováno v:
npj Schizophrenia, Vol 7, Iss 1, Pp 1-7 (2021)
Abstract Cognitive impairment is an important predictor of disability in schizophrenia. Dopamine neurotransmission in cortical brain regions has been suggested to be of importance for higher-order cognitive processes. The aim of this study was to exa
Externí odkaz:
https://doaj.org/article/97839361cd674a3f8ef26c888c06933c
Autor:
Jonas E. Svensson, Cecilia Svanborg, Pontus Plavén-Sigray, Viktor Kaldo, Christer Halldin, Martin Schain, Johan Lundberg
Publikováno v:
Translational Psychiatry, Vol 11, Iss 1, Pp 1-10 (2021)
Abstract Molecular imaging studies have shown low cerebral concentration of serotonin transporter in patients suffering from depression, compared to healthy control subjects. Whether or not this difference also is present before disease onset and aft
Externí odkaz:
https://doaj.org/article/2075c25720d34d31bcf236aafe21fcfd
Autor:
Nakul Ravi Raval, Arafat Nasser, Clara Aabye Madsen, Natalie Beschorner, Emily Eufaula Beaman, Morten Juhl, Szabolcs Lehel, Mikael Palner, Claus Svarer, Pontus Plavén-Sigray, Louise Møller Jørgensen, Gitte Moos Knudsen
Publikováno v:
Frontiers in Neuroscience, Vol 16 (2022)
Positron emission tomography (PET) has become an essential clinical tool for diagnosing neurodegenerative diseases with abnormal accumulation of proteins like amyloid-β or tau. Despite many attempts, it has not been possible to develop an appropriat
Externí odkaz:
https://doaj.org/article/f482c8b7afce44d5bff90eb3d037684f
Autor:
Nakul Ravi Raval, Frederik Gudmundsen, Morten Juhl, Ida Vang Andersen, Nikolaj Speth, Annesofie Videbæk, Ida Nymann Petersen, Jens D. Mikkelsen, Patrick MacDonald Fisher, Matthias Manfred Herth, Pontus Plavén-Sigray, Gitte Moos Knudsen, Mikael Palner
Publikováno v:
Frontiers in Synaptic Neuroscience, Vol 13 (2021)
Parkinson’s disease (PD) is caused by progressive neurodegeneration and characterised by motor dysfunction. Neurodegeneration of dopaminergic neurons also causes aberrations within the cortico-striato-thalamo-cortical (CSTC) circuit, which has been
Externí odkaz:
https://doaj.org/article/208306ca073a449cbd98aebf8b4617c7
Autor:
Tove Freiburghaus, Jonas E. Svensson, Granville J. Matheson, Pontus Plavén-Sigray, Johan Lundberg, Lars Farde, Simon Cervenka
Publikováno v:
NeuroImage, Vol 226, Iss , Pp 117523- (2021)
Dopamine D2 receptors (D2-R) in extrastriatal brain regions are of high interest for research in a wide range of psychiatric and neurologic disorders. Pharmacological competition studies and test–retest experiments have shown high validity and reli
Externí odkaz:
https://doaj.org/article/6490946b021843e5baa0c00c8c19b6cd
Autor:
Jonas E. Svensson, Martin Schain, Pontus Plavén-Sigray, Simon Cervenka, Mikael Tiger, Magdalena Nord, Christer Halldin, Lars Farde, Johan Lundberg
Publikováno v:
NeuroImage, Vol 207, Iss , Pp 116371- (2020)
Externí odkaz:
https://doaj.org/article/379cd0c998594c6ca4bf63ed6360619e
Autor:
Pontus Plavén-Sigray, Granville James Matheson, Zsolt Cselényi, Aurelija Jucaite, Lars Farde, Simon Cervenka
Publikováno v:
EJNMMI Research, Vol 8, Iss 1, Pp 1-10 (2018)
Abstract Purpose The PET radioligand (R)-[11C]PK11195 is used to quantify the 18-kDa translocator protein (TSPO), a marker for glial activation. Since there is no brain region devoid of TSPO, an arterial input function (AIF) is ideally required for q
Externí odkaz:
https://doaj.org/article/14a6295bda984b289ae7eb4a4d2b7d5c
Autor:
Granville J. Matheson, Pontus Plavén-Sigray, Anton Forsberg, Andrea Varrone, Lars Farde, Simon Cervenka
Publikováno v:
EJNMMI Research, Vol 7, Iss 1, Pp 1-6 (2017)
Abstract Purpose Kinetic modelling with metabolite-corrected arterial plasma is considered the gold standard for quantification of [11C]PBR28 binding to the translocator protein (TSPO), since there is no brain region devoid of TSPO that can serve as
Externí odkaz:
https://doaj.org/article/a7b5dc3081944cd7b695a346724dd527
Autor:
Kamilla Woznica Miskowiak, Viktoria Damgaard, Johanna Mariegaard Schandorff, Julian Macoveanu, Gitte Moos Knudsen, Annette Johansen, Pontus Plaven-Sigray, Claus Svarer, Caroline Bruun Fussing, Katrine Cramer, Martin Balslev Jørgensen, Lars Vedel Kessing, Hannelore Ehrenreich
Publikováno v:
Trials, Vol 25, Iss 1, Pp 1-15 (2024)
Abstract Background Cognitive impairment is prevalent across neuropsychiatric disorders but there is a lack of treatment strategies with robust, enduring effects. Emerging evidence indicates that altitude-like hypoxia cognition training may induce lo
Externí odkaz:
https://doaj.org/article/a626539da28d4ef0a67f3810f3c6e4d5