Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Pontus Klein"'
Autor:
Hyeongju Kim, Sophie Lenoir, Angela Helfricht, Taeyang Jung, Zhana K. Karneva, Yejin Lee, Wouter Beumer, Geert B. van der Horst, Herma Anthonijsz, Levi C.M. Buil, Frits van der Ham, Gerard J. Platenburg, Pasi Purhonen, Hans Hebert, Sandrine Humbert, Frédéric Saudou, Pontus Klein, Ji-Joon Song
Publikováno v:
JCI Insight, Vol 7, Iss 17 (2022)
Huntington’s disease (HD) is a late-onset neurological disorder for which therapeutics are not available. Its key pathological mechanism involves the proteolysis of polyglutamine-expanded (polyQ-expanded) mutant huntingtin (mHTT), which generates N
Externí odkaz:
https://doaj.org/article/4386a98caf404dd9a84e53f674710b00
Publikováno v:
PLoS Biology, Vol 8, Iss 4, p e1000349 (2010)
The mechanisms underlying the selective death of substantia nigra (SN) neurons in Parkinson disease (PD) remain elusive. While inactivation of DJ-1, an oxidative stress suppressor, causes PD, animal models lacking DJ-1 show no overt dopaminergic (DA)
Externí odkaz:
https://doaj.org/article/78f01b662edc40ecad99f2127499e886
Autor:
Hyeongju Kim, Sophie Lenoir, Angela Helfricht, Taeyang Jung, Zhana K. Karneva, Yejin Lee, Wouter Beumer, Geert B. van der Horst, Herma Anthonijsz, Levi C.M. Buil, Frits van der Ham, Gerard J. Platenburg, Pasi Purhonen, Hans Hebert, Sandrine Humbert, Frédéric Saudou, Pontus Klein, Ji-Joon Song
Publikováno v:
JCI insight. 7(17)
Huntington's disease (HD) is a late-onset neurological disorder for which therapeutics are not available. Its key pathological mechanism involves the proteolysis of polyglutamine-expanded (polyQ-expanded) mutant huntingtin (mHTT), which generates N-t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::890bc2b9ceb3800a14c6fbdae590d289
https://pubmed.ncbi.nlm.nih.gov/35943803
https://pubmed.ncbi.nlm.nih.gov/35943803
Autor:
Nikolaj H.T. Petersen, Pontus Klein, Cristina Valacca, Anne Bie, Raffaella Magnoni, Marianne T. Pedersen, Andrea C. Lampp, Cathrine K. Fog, Thomas T. Kirkegaard
Publikováno v:
Molecular Genetics and Metabolism. 135:S96
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::abfd06de0dec72d8d46fd42e7f90fea9
https://doi.org/10.1016/j.ymgme.2021.11.251
https://doi.org/10.1016/j.ymgme.2021.11.251
Autor:
Gerard Platenburg, Willeke M. C. van Roon-Mom, Herma Anthonijsz, Hyeongju Kim, Lodewijk J.A. Toonen, Nicholas S. Caron, Levi Buil, Michael R. Hayden, Zhana Karneva, Geert van der Horst, Frits van der Ham, Linda M. van der Graaf, Pontus Klein, Wouter Beumer, Ji-Joon Song
Publikováno v:
Experimental therapeutics – preclinical.
Background QRX-704 is a novel antisense oligonucleotide-based therapeutic approach, aiming to mitigate mutant Huntingtin (mHTT) toxicity, while maintaining physiological HTT function. Proteolytic cleavage of mHTT generates toxic N-terminal fragments
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e5fa5570ed52547349af2c57b84d5030
https://doi.org/10.1136/jnnp-2018-ehdn.237
https://doi.org/10.1136/jnnp-2018-ehdn.237
Autor:
Patrik Brundin, Stefanie Obermüller, Denis Soulet, Maria Björkqvist, Anders Lindqvist, Patrik Önnerfjord, Hindrik Mulder, Ruben Smith, Jia-Yi Li, Karl Bacos, Valentina Fedele, Helena A. Walz, Pontus Klein
Publikováno v:
Human Molecular Genetics. 18:3942-3954
Huntington's disease is a severe progressive neurodegenerative disorder caused by a CAG expansion in the IT15 gene, which encodes huntingtin. The disease primarily affects the neostriatum and cerebral cortex and also associates with increased inciden
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::92057f82562af81aa7a6ddb4dc5e4e48
https://doi.org/10.1093/hmg/ddp336
https://doi.org/10.1093/hmg/ddp336
Autor:
Richard L.M. Faull, Yeliz Koc-Schmitz, Pontus Klein, Jia-Yi Li, Henry J. Waldvogel, Patrik Brundin, Ruben Smith, Markus Plomann
Publikováno v:
Journal of Neurochemistry; 103(1), pp 115-123 (2007)
Huntington’s disease (HD) is an autosomal dominant neurodegenerative disorder caused by a CAG-expansion in the gene encoding the protein huntingtin. The disease is characterized by progressive motor disturbances, cognitive defects, dementia, and we
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e7b204ec667c2063573f10a9a51a2e8a
https://lup.lub.lu.se/record/607693
https://lup.lub.lu.se/record/607693
Autor:
Frank Schnorrer, Pontus Klein, Elisa Motori, Konstanze F. Winklhofer, Cornelia Schönbauer, Rüdiger Klein, Anne Kathrin Müller-Rischart
Publikováno v:
The EMBO journal 33(4), 341-355 (2014). doi:10.1002/embj.201284290
The EMBO Journal
EMBO JOURNAL
The EMBO Journal
EMBO JOURNAL
Synopsis image Glial cell line derived neurotrophic factor (GDNF) improves survival in toxin-models of Parkinson's disease and is currently undergoing clinical development, however the protective mechanism is elusive. This study provides evidence tha
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e0ad2f28b140c59168af44036cb9f31c
https://doi.org/10.1002/embj.201470060
https://doi.org/10.1002/embj.201470060