Zobrazeno 1 - 10
of 74
pro vyhledávání: '"Pontus, Nordenfelt"'
Autor:
Arman Izadi, Yasaman Karami, Eleni Bratanis, Sebastian Wrighton, Hamed Khakzad, Maria Nyblom, Berit Olofsson, Lotta Happonen, Di Tang, Martin Sundwall, Magdalena Godzwon, Yashuan Chao, Alejandro Gomez Toledo, Tobias Schmidt, Mats Ohlin, Michael Nilges, Johan Malmström, Wael Bahnan, Oonagh Shannon, Lars Malmström, Pontus Nordenfelt
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-22 (2024)
Abstract Streptococcus pyogenes can cause invasive disease with high mortality despite adequate antibiotic treatments. To address this unmet need, we have previously generated an opsonic IgG1 monoclonal antibody, Ab25, targeting the bacterial M prote
Externí odkaz:
https://doaj.org/article/be6b5c313b7e4a23b226edf27ac9fea5
Publikováno v:
Frontiers in Cellular and Infection Microbiology, Vol 13 (2023)
Streptococcus pyogenes causes a multitude of local and systemic infections, the most common being pharyngitis in children. Recurrent pharyngeal infections are common and are thought to be due to the re-emergence of intracellular GAS upon completion o
Externí odkaz:
https://doaj.org/article/07b0d2fbdcec4f34824e98d27949d526
Autor:
Wael Bahnan, Lotta Happonen, Hamed Khakzad, Vibha Kumra Ahnlide, Therese deNeergaard, Sebastian Wrighton, Oscar André, Eleni Bratanis, Di Tang, Thomas Hellmark, Lars Björck, Oonagh Shannon, Lars Malmström, Johan Malmström, Pontus Nordenfelt
Publikováno v:
EMBO Molecular Medicine, Vol 15, Iss 2, Pp n/a-n/a (2023)
Abstract Group A streptococci have evolved multiple strategies to evade human antibodies, making it challenging to create effective vaccines or antibody treatments. Here, we have generated antibodies derived from the memory B cells of an individual w
Externí odkaz:
https://doaj.org/article/2bcb7da2abe14c5fb5c5a0341f1349d2
Publikováno v:
Frontiers in Microbiology, Vol 14 (2023)
Group A streptococcus (GAS) is a highly adapted, human-specific pathogen that is known to manipulate the immune system through various mechanisms. GAS’ M protein constitutes a primary target of the immune system due to its spatial configuration and
Externí odkaz:
https://doaj.org/article/2da9ddbc4b9a4aadb088361a5272f306
Autor:
Therese de Neergaard, Anna Bläckberg, Hanna Ivarsson, Sofia Thomasson, Vibha Kumra Ahnlide, Sounak Chowdhury, Hamed Khakzad, Wael Bahnan, Johan Malmström, Magnus Rasmussen, Pontus Nordenfelt
Publikováno v:
Microbiology Spectrum, Vol 10, Iss 6 (2022)
ABSTRACT The human pathogen Streptococcus pyogenes causes substantial morbidity and mortality. It is unclear if antibodies developed after infections with this pathogen are opsonic and if they are strain specific or more broadly protective. Here, we
Externí odkaz:
https://doaj.org/article/88ea6ae07644475ba144a4b946cc7bf8
Autor:
Vibha Kumra Ahnlide, Johannes Kumra Ahnlide, Sebastian Wrighton, Jason P Beech, Pontus Nordenfelt
Publikováno v:
eLife, Vol 11 (2022)
Antibody binding to cell surface proteins plays a crucial role in immunity, and the location of an epitope can altogether determine the immunological outcome of a host-target interaction. Techniques available today for epitope identification are cost
Externí odkaz:
https://doaj.org/article/6f9947c9651d4a3990b0f8b84d6011fc
Autor:
Wael Bahnan, Sebastian Wrighton, Martin Sundwall, Anna Bläckberg, Olivia Larsson, Urban Höglund, Hamed Khakzad, Magdalena Godzwon, Maria Walle, Elisabeth Elder, Anna Söderlund Strand, Lotta Happonen, Oscar André, Johannes Kumra Ahnlide, Thomas Hellmark, Vidar Wendel-Hansen, Robert PA. Wallin, Johan Malmstöm, Lars Malmström, Mats Ohlin, Magnus Rasmussen, Pontus Nordenfelt
Publikováno v:
Frontiers in Immunology, Vol 12 (2022)
Spike-specific antibodies are central to effective COVID19 immunity. Research efforts have focused on antibodies that neutralize the ACE2-Spike interaction but not on non-neutralizing antibodies. Antibody-dependent phagocytosis is an immune mechanism
Externí odkaz:
https://doaj.org/article/f92905abfadc4d269db7f2ae1d052963
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-17 (2020)
Therapeutic siRNA becomes trapped in endosomes, limiting its efficacy. Here the authors use fluorescently-tagged galectin-9 as a biosensor for membrane damage to monitor endosomal escape of cholesterol-conjugated siRNA following treatment of small mo
Externí odkaz:
https://doaj.org/article/d19329c8d4634c19add07accb1157c0d
Autor:
Anna Bläckberg, Therese de Neergaard, Inga-Maria Frick, Pontus Nordenfelt, Rolf Lood, Magnus Rasmussen
Publikováno v:
Frontiers in Microbiology, Vol 12 (2021)
IntroductionStreptococcus dysgalactiae can cause severe recurrent infections. This study aimed to investigate antibody responses following S. dysgalactiae bacteraemia and possible development of protective immunity.Materials and MethodsPatients with
Externí odkaz:
https://doaj.org/article/35237043c45b4867be416a180e1b3520
Autor:
Lotta Happonen, Simon Hauri, Gabriel Svensson Birkedal, Christofer Karlsson, Therese de Neergaard, Hamed Khakzad, Pontus Nordenfelt, Mats Wikström, Magdalena Wisniewska, Lars Björck, Lars Malmström, Johan Malmström
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-15 (2019)
Characterizing host-pathogen protein interactions can help elucidate the molecular basis of bacterial infections. Here, the authors use an integrative proteomics approach to generate a quantitative map of protein interactions between Streptococcus py
Externí odkaz:
https://doaj.org/article/5e6b3b9bfaf4481895310369f23b17c5