Zobrazeno 1 - 7
of 7
pro vyhledávání: '"Pontus, Hegardt"'
Autor:
Thomas Vifian, Tatiana G Stilou, Simon Feldbaek Nielsen, Maja Lambert, Jens Christian Højland Larsen, Tine Skak-Nielsen, Anders Soehoel, Pontus Hegardt, Lene M. Hansen, Nina Østergaard Knudsen, Morten Dahl Sørensen, Mogens Larsen, Cecilia Eskilsson, Steen Laursen, Stefan Eirefelt, Henrik Pettersson, Anna Ollerstam
Publikováno v:
Journal of Medicinal Chemistry. 63:14502-14521
We describe the design of a novel PDE4 scaffold and the exploration of the dual-soft concept to reduce systemic side effects via rapid elimination: introducing ester functionalities that can be inactivated in blood as well as by the liver (dual-soft)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1fb38d7abc4b9986a9e38e75c9c4ae01
https://doi.org/10.1021/acs.jmedchem.0c00797
https://doi.org/10.1021/acs.jmedchem.0c00797
Autor:
Jens, Larsen, Maja, Lambert, Henrik, Pettersson, Thomas, Vifian, Mogens, Larsen, Anna, Ollerstam, Pontus, Hegardt, Cecilia, Eskilsson, Steen, Laursen, Anders, Soehoel, Tine, Skak-Nielsen, Lene M, Hansen, Nina Ø, Knudsen, Stefan, Eirefelt, Morten D, Sørensen, Tatiana G, Stilou, Simon F, Nielsen
Publikováno v:
Journal of medicinal chemistry. 63(23)
We describe the design of a novel PDE4 scaffold and the exploration of the dual-soft concept to reduce systemic side effects via rapid elimination: introducing ester functionalities that can be inactivated in blood as well as by the liver (dual-soft)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::91d778dd5cf2a7a2234d7f9358d53149
https://pubmed.ncbi.nlm.nih.gov/33054196
https://pubmed.ncbi.nlm.nih.gov/33054196
Autor:
Jakob Felding, Morten Dahl Sørensen, Karen Margrethe Engell, Pontus Hegardt, Jens Christian Højland Larsen, Anne Marie Vinggaard, Anders Søhoel, Pia Refer, Simon Feldbaek Nielsen, Christina Andersson, Lotte G. Ladefoged, Tina Dahlerup Poulsen, Thorsten Thormann
Publikováno v:
Journal of Medicinal Chemistry. 57:5893-5903
Development of orally available phosphodiesterase 4 (PDE4) inhibitors as anti-inflammatory drugs has been going on for decades. However, only roflumilast has received FDA approval. One key challenge has been the low therapeutic window observed in the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bba6a2198c41f3791da043fbf961f273
https://doi.org/10.1021/jm500378a
https://doi.org/10.1021/jm500378a
Autor:
Shorena Janelidze, Pontus Hegardt, Peter Siesjö, Karin Enell Smith, Leif G. Salford, Edward Visse, Magnus Esbjörnsson, Wiaam Badn, M. A. Fellert, Anna Darabi
Publikováno v:
Scandinavian journal of immunology. 65(3)
Interferon gamma (IFN-gamma) has successfully been used in immunotherapy of different experimental tumours. Mechanistically, IFN-gamma has extensive effects on the immune system including release of nitric oxide (NO) by upregulation of the inducible
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c9f403bdf6d2d843d49e800fd17bf3e4
https://pubmed.ncbi.nlm.nih.gov/17309784
https://pubmed.ncbi.nlm.nih.gov/17309784
Autor:
Peter Siesjö, Anna C. Johansson, Bengt Widegren, Pontus Hegardt, Shorena Janelidze, Edward Visse
Publikováno v:
Journal of neuroimmunology. 123(1-2)
Nitric oxide (NO) can modulate both tumor growth and antitumor immune responses. In order to elucidate the mechanism of curative therapeutic immunization with IFNgamma-producing glioma cells, we examined the expression of inducible nitric oxide synth
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::94aecd73c545916a66c77f30df58a41c
https://pubmed.ncbi.nlm.nih.gov/11880158
https://pubmed.ncbi.nlm.nih.gov/11880158
Publikováno v:
Cellular immunology. 200(2)
The role of nitric oxide (NO) and adherent spleen cells in systemic immunosuppression developing in animals carrying malignant glioma isografts was analyzed. Rats harboring a subcutaneous glioma isograft for 3 weeks were immunized with glioma cells g
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::84d8d1cab8aba76532daf41a6cfd861d
https://pubmed.ncbi.nlm.nih.gov/10753503
https://pubmed.ncbi.nlm.nih.gov/10753503
Autor:
Barbro Sjögren, Hans Olov Sjögren, Christian Kjellman, Bengt Widegren, Inderpreet Sur, Li Li, Pontus Hegardt
Publikováno v:
Karolinska Institutet
The role of nitric oxide (NO) produced by adherent spleen cells in the systemic immunosuppression developing in tumor-bearing hosts was investigated. After therapeutic immunization of rats carrying an intrahepatic colon carcinoma, H1D2, the spleen ce
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::63cfccf27ccfbee60cce2af746b71274
http://www.ncbi.nlm.nih.gov/pubmed/11761444
http://www.ncbi.nlm.nih.gov/pubmed/11761444
