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Akademický článek

Intracranial administration of deglycosylated C-terminal-specific anti-Aβ antibody efficiently clears amyloid plaques without activating microglia in amyloid-depositing transgenic mice

Autor: Gordon Marcia N, Gottschall Paul E, Pons Jaume, Ronan Victoria, Grimm Jan, Rosenthal Arnon, Wilcock Donna M, Carty Niki C, Morgan Dave

Publikováno v: Journal of Neuroinflammation, Vol 3, Iss 1, p 11 (2006)

Abstract Background Antibodies against the Aß peptide clear Aß deposits when injected intracranially. Deglycosylated antibodies have reduced effector functions compared to their intact counterparts, potentially avoiding immune activation. Methods D

Externí odkaz: https://doaj.org/article/40ae9459dc1e4d1baebf639d3c2bd36e

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Akademický článek

Expression of Toll-like receptor 2 is up-regulated in monocytes from patients with chronic obstructive pulmonary disease

Autor: Ferrer Joana, López Meritxell, Santos Carmen, Regueiro Verónica, Sauleda Jaume, Pons Jaume, Agustí Alvar GN, Bengoechea José A

Publikováno v: Respiratory Research, Vol 7, Iss 1, p 64 (2006)

Abstract Background Chronic obstructive pulmonary disease (COPD) is characterised by pulmonary and systemic inflammation which flare-up during episodes of acute exacerbation (AECOPD). Given the role of Toll-like receptors (TLRs) in the induction of i

Externí odkaz: https://doaj.org/article/a73715c673f249d68690edb8e0106151

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