Zobrazeno 1 - 10
of 34
pro vyhledávání: '"Poncho Meisenheimer"'
Publikováno v:
ACS Omega, Vol 7, Iss 6, Pp 5429-5436 (2022)
Externí odkaz:
https://doaj.org/article/d22db13ce643462d9119d37ae3664e9f
Autor:
Robert B. Kargbo, Alexander Sherwood, Andrew Walker, Nicholas V. Cozzi, Raymond E. Dagger, Jessica Sable, Kelsey O’Hern, Kristi Kaylo, Tura Patterson, Gary Tarpley, Poncho Meisenheimer
Publikováno v:
ACS Omega, Vol 5, Iss 27, Pp 16959-16966 (2020)
Externí odkaz:
https://doaj.org/article/48d2c06570584f16b165e38b99e1fef2
Autor:
Tura Patterson, Andrew Walker, Poncho Meisenheimer, Robert B. Kargbo, Raymond E. Dagger, Jessica Sable, Kristi W. Kaylo, Alexander M. Sherwood, Kelsey O’Hern, Nicholas V. Cozzi, Gary Tarpley
Publikováno v:
ACS Omega, Vol 5, Iss 27, Pp 16959-16966 (2020)
ACS Omega
ACS Omega
A second-generation kilogram-scale synthesis of the psychedelic tryptamine psilocybin has been developed. The synthesis was designed to address several challenges first encountered with the scale-up of previously described literature procedures, whic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::663479ee822815218ef4ade53fad7f10
https://doi.org/10.1021/acsomega.0c02387
https://doi.org/10.1021/acsomega.0c02387
Autor:
Adam L. Halberstadt, Robert B. Kargbo, Alexander M. Sherwood, Poncho Meisenheimer, Kristi W. Kaylo, Adam K. Klein, John D. McCorvy
Publikováno v:
Journal of Natural Products. 83:461-467
A general synthetic method was developed to access known tryptamine natural products present in psilocybin-producing mushrooms. In vitro and in vivo experiments were then conducted to inform speculations on the psychoactive properties, or lack thereo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fa9de7705e48582ab0e906cd5e38ec5c
https://doi.org/10.1021/acs.jnatprod.9b01061
https://doi.org/10.1021/acs.jnatprod.9b01061
Publikováno v:
Synthesis. 52:688-694
Described herein is an improved synthesis of 3-[2-(dimethylamino)ethyl]-1H-indol-4-yl dihydrogen phosphate (psilocybin). The protocol outlines: synthesis of multigram quantities of psilocybin, identification of critical in-process parameters, and iso
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9d9fe81843c076a964a61830aab7d5f2
https://doi.org/10.1055/s-0039-1691565
https://doi.org/10.1055/s-0039-1691565
Autor:
Alexander M. Sherwood, Robert B. Kargbo, Kristi W. Kaylo, Nicholas V. Cozzi, Poncho Meisenheimer, James A. Kaduk
Publikováno v:
Acta crystallographica. Section C, Structural chemistry. 78(Pt 1)
Psilocybin {systematic name: 3-[2-(dimethylamino)ethyl]-1H-indol-4-yl dihydrogen phosphate} is a zwitterionic tryptamine natural product found in numerous species of fungi known for their psychoactive properties. Following its structural elucidation
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dbb749990a0120f00ea6e924450343fa
https://pubmed.ncbi.nlm.nih.gov/35119383
https://pubmed.ncbi.nlm.nih.gov/35119383
Autor:
James Kaduk, Alexander Sherwood, Robert Kargbo, Kristi Kaylo, Poncho Meisenheimer, Nicholas Cozzi
Publikováno v:
Acta Crystallographica Section A Foundations and Advances. 78:a273-a273
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7a21e07f8f4ed79f37ff7011fa05a3d1
https://doi.org/10.1107/s2053273322097261
https://doi.org/10.1107/s2053273322097261
Autor:
Kilian Huber, Mei Cong, David H. Drewry, Hicham Zegzouti, Jennifer Wilkinson, Carrow I. Wells, Chad Zimprich, James D Vasta, Byounghoon Brian Hwang, Cesear Corona, Poncho Meisenheimer, Marie K. Schwinn, Kathryn M. Pugh, Matthew B. Robers, Morgan R. Ingold, Timothy M. Willson, Julie E. Pickett
Publikováno v:
Nature Communications
Nature Communications, Vol 11, Iss 1, Pp 1-11 (2020)
Nature Communications, Vol 11, Iss 1, Pp 1-11 (2020)
Concerted multidisciplinary efforts have led to the development of Cyclin-Dependent Kinase inhibitors (CDKi’s) as small molecule drugs and chemical probes of intracellular CDK function. However, conflicting data has been reported on the inhibitory
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::380a7177e81c7ed553a8701975fef63c
https://doi.org/10.1038/s41467-020-16559-0
https://doi.org/10.1038/s41467-020-16559-0
Autor:
Matthew B. Robers, Timothy M. Willson, Poncho Meisenheimer, Mei Cong, Kilian Huber, Kathryn Maria Pugh, David Drewry, Julie E. Pickett, Morgan R. Ingold, Chad A. Zimprich, Jennifer Wilkinson, Cesear R. Corona, Jim Vasta, Carrow Wells
A panel of cell-permeable energy transfer probes has been developed to quantify target occupancy for all 21 CDKs in live, intact cells. Here we present the first comprehensive evaluation of intracellular isozyme potency and selectivity for a collecti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0d28073099725530de5081a4af311060
https://doi.org/10.26434/chemrxiv.11401419
https://doi.org/10.26434/chemrxiv.11401419
Autor:
James R. Burke, Matthew B. Robers, James D Vasta, H. Ribeiro, B. Arey, G. Locke, Jonathan Lippy, Charu Chaudhry, Joseph A. Tino, Mark A. Pattoli, Stacey Skala, Andrew J. Tebben, Lixia Zhang, L. L. Ong, Scott H. Watterson, L. Monereau, Poncho Meisenheimer
Publikováno v:
SLAS discovery : advancing life sciences RD. 25(2)
Protein kinases are intensely studied mediators of cellular signaling. While traditional biochemical screens are capable of identifying compounds that modulate kinase activity, these assays are limited in their capability of predicting compound behav
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1bce774a861c747b37f478bb8945a972
https://pubmed.ncbi.nlm.nih.gov/31709883
https://pubmed.ncbi.nlm.nih.gov/31709883