Zobrazeno 1 - 10
of 45
pro vyhledávání: '"Pompiliu Ionescu"'
Autor:
Edmond I. Eger, Donald D. Koblin, Michael J. Halsey, Tomas Hudlicky, Rulin Fan, Pompiliu Ionescu, Ba V. Nguyen, Kurt Königsberger, Michael J. Laster
Publikováno v:
Anesthesia & Analgesia. 93:922-927
UNLABELLED The differences in potencies of optical isomers of anesthetics support the hypothesis that anesthetics act by specific receptor interactions. Diastereoisomerism and geometrical isomerism offer further tests of this hypothesis but have not
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4481ef62fa5d8a5c40b35392b5b10cc9
https://doi.org/10.1097/00000539-200110000-00025
https://doi.org/10.1097/00000539-200110000-00025
Autor:
Edmond I. Eger, Pompiliu Ionescu, Donald D. Koblin, Michael J. Halsey, Tomas Hudlicky, Diane Gong, Michael J. Laster
Publikováno v:
Anesthesia & Analgesia. 88:1161-1167
The several potent inhaled anesthetics released for clinical use in the past four decades have been halogenated ethers, and, with one exception, methyl ethyl ethers.In the present report, we detail some structural and physical properties associated w
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c681d806b5b7937f017c8cc2f405b810
https://doi.org/10.1097/00000539-199905000-00036
https://doi.org/10.1097/00000539-199905000-00036
Autor:
Michael J. Laster, Donald D. Koblin, Diane Gong, Edmond I. Eger, Pompiliu Ionescu, James M. Sonner, Tomas Hudlicky, Michael J. Halsey
Publikováno v:
Anesthesia & Analgesia. 88:884-892
UNLABELLED Some inhaled compounds cause convulsions. To better appreciate the physical basis for this property, we correlated the partial pressures that produced convulsions in rats with the lipophilicity (nonpolarity) and hydrophilicity (polarity) o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3acf4581d808fef21068f64d80d6b63b
https://doi.org/10.1097/00000539-199904000-00037
https://doi.org/10.1097/00000539-199904000-00037
Autor:
Michael J. Laster, R. Adron Harris, Tomas Hudlicky, Pompiliu Ionescu, James R. Trudell, Joan J. Kendig, Edmond I. Eger, Andrew Pohorille, Diane Gong
Publikováno v:
Anesthesia & Analgesia. 88:867-876
The Meyer-Overton hypothesis predicts that the potency of conventional inhaled anesthetics correlates inversely with lipophilicity: minimum alveolar anesthetic concentration (MAC) 3 the olive oil/gas partition coefficient equals a constant of approxi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::45225d7d2cacc9ccbec1659f74a115b9
https://doi.org/10.1097/00000539-199904000-00035
https://doi.org/10.1097/00000539-199904000-00035
Publikováno v:
Anesthesia & Analgesia. 87:963-966
We assessed the effect of rat strain on susceptibility to anesthesia and convulsions produced by inhaled compounds. We determined the minimum alveolar anesthetic concentration (MAC) of desflurane and nitrous oxide, and the convulsive 50% effective do
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::84f834ff946e83cb4194d952b261a2d9
https://doi.org/10.1213/00000539-199810000-00040
https://doi.org/10.1213/00000539-199810000-00040
Autor:
Edmond I. Eger, Donald D. Koblin, Diane Gong, Zexu Fang, James R. Trudell, Pompiliu Ionescu, Michael J. Halsey, Michael J. Laster
Publikováno v:
Anesthesia & Analgesia. 87:419-424
We assessed the anesthetic properties of helium and neon at hyperbaric pressures by testing their capacity to decrease anesthetic requirement for desflurane using electrical stimulation of the tail as the anesthetic endpoint (i.e., the minimum alveol
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bdd2d9fa3b8e80e01c906c85c9b1585e
https://doi.org/10.1213/00000539-199808000-00035
https://doi.org/10.1213/00000539-199808000-00035
Publikováno v:
Anesthesia & Analgesia. 86:1070-1074
UNLABELLED Uptake of inhaled anesthetics may be measured as the amount of anesthetic infused to maintain a constant alveolar concentration of anesthetic. This method assumes that the patient absorbs all of the infused anesthetic, and that none is los
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9c688daaf4eac15d8291b499aa6f2766
https://doi.org/10.1097/00000539-199805000-00032
https://doi.org/10.1097/00000539-199805000-00032
Publikováno v:
Anesthesiology. 88:914-921
Background In an attempt to combine the advantage of the lower solubilities of new inhaled anesthetics with the lesser cost of older anesthetics, some clinicians substitute the former for the latter toward the end of anesthesia. The authors tried to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8914528c5bfd2bf53fd8a1b9b0c7ca6f
https://doi.org/10.1097/00000542-199804000-00010
https://doi.org/10.1097/00000542-199804000-00010
Publikováno v:
Anesthesia & Analgesia. 86:173-178
UNLABELLED Nonimmobilizers (inhaled compounds that do not suppress movement in response to a noxious stimulus) resemble anesthetics in their capacity to suppress memory, but unlike anesthetics, they can cause convulsions. Higher concentrations of non
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::98e66f4f9144fc00864ccc51fd391c21
https://doi.org/10.1097/00000539-199801000-00034
https://doi.org/10.1097/00000539-199801000-00034
Autor:
Richard B. Weiskopf, Michael J. Laster, Diane Gong, Russell L. Kerschmann, Pompiliu Ionescu, Edmond I. Eger
Publikováno v:
Anesthesia & Analgesia. 85:1164-1170
Carbon dioxide absorbents degrade both halothane and sevoflurane to toxic unsaturated compounds (CF 2 = CBrCl and CH 2 F-O-C[= CF 2 ][CF 3 ] [i.e., Compound A], respectively). Given the long history of safe administration of halothane, comparable tox
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b72cd9b8108c809d113f35606b1e8019
https://doi.org/10.1213/00000539-199711000-00037
https://doi.org/10.1213/00000539-199711000-00037