Genome-wide programmable transcriptional memory by CRISPR-based epigenome editing

Autor: Nuñez, James K., Chen, Jin, Pommier, Greg C., Cogan, J. Zachery, Replogle, Joseph M., Adriaens, Carmen, Ramadoss, Gokul N., Shi, Quanming, Hung, King L., Samelson, Avi J., Pogson, Angela N., Kim, James Y.S., Chung, Amanda, Leonetti, Manuel D., Chang, Howard Y., Kampmann, Martin, Bernstein, Bradley E., Hovestadt, Volker, Gilbert, Luke A., Weissman, Jonathan S.

Publikováno v: In Cell 29 April 2021 184(9):2503-2519

Combinatorial effector targeting (COMET) for transcriptional modulation and locus-specific biochemistry.

Autor: Wilson CM; Tetrad Graduate Program, University of California, San Francisco, CA 94158, USA.; Department of Urology, University of California, San Francisco, CA 94158, USA.; Helen Diller Family Comprehensive Cancer Center, University of California, San Francisco, San Francisco, CA 94158, USA.; Arc Institute, Palo Alto, CA 94304, USA., Pommier GC; Department of Urology, University of California, San Francisco, CA 94158, USA.; Helen Diller Family Comprehensive Cancer Center, University of California, San Francisco, San Francisco, CA 94158, USA.; Current Address: Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA., Richman DD; Department of Computer Science, Stanford University, Stanford, CA 94305, USA., Sambold N; Arc Institute, Palo Alto, CA 94304, USA., Hussmann JA; Current Address: Prime Medicine, Cambridge, MA 02142, USA.; Howard Hughes Medical Institute, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.; Whitehead Institute for Biomedical Research, Massachusetts Institute of Technology, Cambridge, MA 02142, USA., Weissman JS; Howard Hughes Medical Institute, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.; Whitehead Institute for Biomedical Research, Massachusetts Institute of Technology, Cambridge, MA 02142, USA.; David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.; Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA., Gilbert LA; Department of Urology, University of California, San Francisco, CA 94158, USA.; Helen Diller Family Comprehensive Cancer Center, University of California, San Francisco, San Francisco, CA 94158, USA.; Arc Institute, Palo Alto, CA 94304, USA.; Lead contact.

Publikováno v: BioRxiv : the preprint server for biology [bioRxiv] 2024 Oct 28. Date of Electronic Publication: 2024 Oct 28.