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From PROTAC to inhibitor: Structure-guided discovery of potent and orally bioavailable BET inhibitors.

Autor: Koravovic M; University of Belgrade, Faculty of Pharmacy, Department of Organic Chemistry, Vojvode Stepe 450, 11221, Belgrade, Serbia., Mayasundari A; Department of Chemical Biology & Therapeutics, St. Jude Children's Research Hospital, 262 Danny Thomas Place, Memphis, TN, 38105, USA., Tasic G; University of Belgrade, Faculty of Pharmacy, Department of Organic Chemistry, Vojvode Stepe 450, 11221, Belgrade, Serbia., Keramatnia F; Department of Chemical Biology & Therapeutics, St. Jude Children's Research Hospital, 262 Danny Thomas Place, Memphis, TN, 38105, USA., Stachowski TR; Department of Chemical Biology & Therapeutics, St. Jude Children's Research Hospital, 262 Danny Thomas Place, Memphis, TN, 38105, USA., Cui H; Department of Chemistry, University of Minnesota, 207 Pleasant Street SE, Minneapolis, MN, 55455, United States., Chai SC; Department of Chemical Biology & Therapeutics, St. Jude Children's Research Hospital, 262 Danny Thomas Place, Memphis, TN, 38105, USA., Jonchere B; Department of Tumour Cell Biology, St. Jude Children's Research Hospital, 262 Danny Thomas Place, Memphis, TN, 38105, USA., Yang L; Department of Chemical Biology & Therapeutics, St. Jude Children's Research Hospital, 262 Danny Thomas Place, Memphis, TN, 38105, USA., Li Y; Department of Chemical Biology & Therapeutics, St. Jude Children's Research Hospital, 262 Danny Thomas Place, Memphis, TN, 38105, USA., Fu X; Department of Chemical Biology & Therapeutics, St. Jude Children's Research Hospital, 262 Danny Thomas Place, Memphis, TN, 38105, USA., Hiltenbrand R; Department of Pathology, St. Jude Children's Research Hospital, 262 Danny Thomas Place, Memphis, TN, 38105, USA., Paul L; Department of Developmental Neurobiology, St. Jude Children's Research Hospital, 262 Danny Thomas Place, Memphis, TN, 38105, USA., Mishra V; Department of Pathology, St. Jude Children's Research Hospital, 262 Danny Thomas Place, Memphis, TN, 38105, USA., Klco JM; Department of Pathology, St. Jude Children's Research Hospital, 262 Danny Thomas Place, Memphis, TN, 38105, USA., Roussel MF; Department of Tumour Cell Biology, St. Jude Children's Research Hospital, 262 Danny Thomas Place, Memphis, TN, 38105, USA., Pomerantz WC; Department of Chemistry, University of Minnesota, 207 Pleasant Street SE, Minneapolis, MN, 55455, United States., Fischer M; Department of Chemical Biology & Therapeutics, St. Jude Children's Research Hospital, 262 Danny Thomas Place, Memphis, TN, 38105, USA., Rankovic Z; Department of Chemical Biology & Therapeutics, St. Jude Children's Research Hospital, 262 Danny Thomas Place, Memphis, TN, 38105, USA. Electronic address: zoran.rankovic@stjude.org., Savic V; University of Belgrade, Faculty of Pharmacy, Department of Organic Chemistry, Vojvode Stepe 450, 11221, Belgrade, Serbia. Electronic address: vladimir.savic@pharmacy.bg.ac.rs.

Publikováno v: European journal of medicinal chemistry [Eur J Med Chem] 2023 May 05; Vol. 251, pp. 115246. Date of Electronic Publication: 2023 Mar 04.

Oxidation increases the strength of the methionine-aromatic interaction.

Autor: Lewis AK; Department of Biomedical Engineering, University of Minnesota-Twin Cities, Minneapolis, Minnesota, USA., Dunleavy KM; Department of Chemistry and Biochemistry, University of Minnesota-Duluth, Duluth, Minnesota, USA., Senkow TL; Department of Biomedical Engineering, University of Minnesota-Twin Cities, Minneapolis, Minnesota, USA., Her C; Department of Biochemistry, Molecular Biology and Biophysics, University of Minnesota-Twin Cities, Minneapolis, Minnesota, USA., Horn BT; Department of Chemistry and Biochemistry, University of Minnesota-Duluth, Duluth, Minnesota, USA., Jersett MA; Department of Chemistry and Biochemistry, University of Minnesota-Duluth, Duluth, Minnesota, USA., Mahling R; Department of Chemistry and Biochemistry, University of Minnesota-Duluth, Duluth, Minnesota, USA., McCarthy MR; Department of Biochemistry, Molecular Biology and Biophysics, University of Minnesota-Twin Cities, Minneapolis, Minnesota, USA., Perell GT; Department of Chemistry, University of Minnesota-Twin Cities, Minneapolis, Minnesota, USA., Valley CC; Department of Biomedical Engineering, University of Minnesota-Twin Cities, Minneapolis, Minnesota, USA., Karim CB; Department of Biochemistry, Molecular Biology and Biophysics, University of Minnesota-Twin Cities, Minneapolis, Minnesota, USA., Gao J; Department of Chemistry, University of Minnesota-Twin Cities, Minneapolis, Minnesota, USA., Pomerantz WC; Department of Chemistry, University of Minnesota-Twin Cities, Minneapolis, Minnesota, USA., Thomas DD; Department of Biochemistry, Molecular Biology and Biophysics, University of Minnesota-Twin Cities, Minneapolis, Minnesota, USA., Cembran A; Department of Chemistry and Biochemistry, University of Minnesota-Duluth, Duluth, Minnesota, USA., Hinderliter A; Department of Chemistry and Biochemistry, University of Minnesota-Duluth, Duluth, Minnesota, USA., Sachs JN; Department of Biomedical Engineering, University of Minnesota-Twin Cities, Minneapolis, Minnesota, USA.

Publikováno v: Nature chemical biology [Nat Chem Biol] 2016 Oct; Vol. 12 (10), pp. 860-6. Date of Electronic Publication: 2016 Aug 22.

Prediction of (19)F NMR Chemical Shifts in Labeled Proteins: Computational Protocol and Case Study.

Autor: Isley WC 3rd; Department of Chemistry, Chemical Theory Center, and Supercomputing Institute, University of Minnesota , 207 Pleasant Street SE, Minneapolis, Minnesota 55455, United States., Urick AK; Department of Chemistry, Chemical Theory Center, and Supercomputing Institute, University of Minnesota , 207 Pleasant Street SE, Minneapolis, Minnesota 55455, United States., Pomerantz WC; Department of Chemistry, Chemical Theory Center, and Supercomputing Institute, University of Minnesota , 207 Pleasant Street SE, Minneapolis, Minnesota 55455, United States., Cramer CJ; Department of Chemistry, Chemical Theory Center, and Supercomputing Institute, University of Minnesota , 207 Pleasant Street SE, Minneapolis, Minnesota 55455, United States.

Publikováno v: Molecular pharmaceutics [Mol Pharm] 2016 Jul 05; Vol. 13 (7), pp. 2376-86. Date of Electronic Publication: 2016 Jun 02.

Correction to Letter: Fluorinated Aromatic Amino Acids Are Sensitive (19)F NMR Probes for Bromodomain-Ligand Interactions.

Autor: Mishra NK, Urick AK, Ember SW, Schönbrunn E, Pomerantz WC

Publikováno v: ACS chemical biology [ACS Chem Biol] 2016 Apr 15; Vol. 11 (4), pp. 1149. Date of Electronic Publication: 2016 Feb 02.