Achieving collimated gamma-ray emission from direct laser acceleration

Autor: Tangtartharakul, Kavin, Fauvel, Gaetan, Meir, Talia, Condamine, Florian, Weber, Stefan, Pomerantz, Ishay, Manuel, Mario, Arefiev, Alexey

In this paper, we investigate the conditions under which direct laser acceleration (DLA) of electrons in a laser-irradiated plasma can produce distinct photon emission profiles, focusing on the mechanisms responsible for single-lobed versus double-lo

Externí odkaz: http://arxiv.org/abs/2409.16506

A Comprehensive Characterization of the Neutron Fields Produced by the Apollon Petawatt Laser

Autor: Lelièvre, Ronan, Yao, Weipeng, Waltenspiel, Tessa, Cohen, Itamar, Beck, Arie, Cohen, Erez, Michaeli, David, Pomerantz, Ishay, Gautier, Donald Cort, Trompier, François, Ducasse, Quentin, Koseoglou, Pavlos, Söderström, Pär-Anders, Mathieu, François, Allaoua, Amokrane, Fuchs, Julien

Since two decades, laser-driven neutron emissions are studied as they represent a complementary source to conventional neutron sources, with further more different characteristics (i.e. shorter bunch duration and higher number of neutrons per bunch).

Externí odkaz: http://arxiv.org/abs/2311.12653

Technical Design Report for the LUXE Experiment

Autor: Abramowicz, H., Soto, M. Almanza, Altarelli, M., Aßmann, R., Athanassiadis, A., Avoni, G., Behnke, T., Benettoni, M., Benhammou, Y., Bhatt, J., Blackburn, T., Blanch, C., Bonaldo, S., Boogert, S., Borysov, O., Borysova, M., Boudry, V., Breton, D., Brinkmann, R., Bruschi, M., Burkart, F., Büßer, K., Cavanagh, N., Corso, F. Dal, Decking, W., Deniaud, M., Diner, O., Dosselli, U., Elad, M., Epshteyn, L., Esperante, D., Ferber, T., Firlej, M., Fiutowski, T., Fleck, K., Fuster-Martinez, N., Gadow, K., Gaede, F., Gallas, A., Cabrera, H. Garcia, Gerstmayr, E., Ghenescu, V., Giorato, M., Golubeva, N., Grojean, C., Grutta, P., Grzelak, G., Hallford, J., Hartman, L., Heinemann, B., Heinzl, T., Helary, L., Hendriks, L., Hoffmann, M., Horn, D., Huang, S., Huang, X., Idzik, M., Irles, A., Jacobs, R., King, B., Klute, M., Kropf, A., Kroupp, E., Lahno, H., Manghi, F. Lasagni, Lawhorn, J., Levanon, A., Levi, A., Levinson, L., Levy, A., Levy, I., Liberman, A., Liss, B., List, B., List, J., Lohmann, W., Maalmi, J., Madlener, T., Malka, V., Marsault, T., Mattiazzo, S., Meloni, F., Miron, D., Morandin, M., Moroń, J., Nanni, J., Neagu, A. T., Negodin, E., Paccagnella, A., Pantano, D., Pietruch, D., Pomerantz, I., Pöschl, R., Potlog, P. M., Prasad, R., Quishpe, R., Ranken, E., Ringwald, A., Roich, A., Salgado, F., Santra, A., Sarri, G., Sävert, A., Sbrizzi, A., Schmitt, S., Schulthess, I., Schuwalow, S., Seipt, D., Simi, G., Soreq, Y., Spataro, D., Streeter, M., Swientek, K., Hod, N. Tal, Teter, T., Thiebault, A., Thoden, D., Trevisani, N., Urmanov, R., Vasiukov, S., Walker, S., Warren, M., Wing, M., Yap, Y. C., Zadok, N., Zanetti, M., Żarnecki, A. F., Zbińkowski, P., Zembaczyński, K., Zepf, M., Zerwas, D., Ziegler, W., Zuffa, M.

This Technical Design Report presents a detailed description of all aspects of the LUXE (Laser Und XFEL Experiment), an experiment that will combine the high-quality and high-energy electron beam of the European XFEL with a high-intensity laser, to e

Externí odkaz: http://arxiv.org/abs/2308.00515

PARG is essential for Polθ-mediated DNA end-joining by removing repressive poly-ADP-ribose marks

Autor: Umeshkumar Vekariya, Leonid Minakhin, Gurushankar Chandramouly, Mrityunjay Tyagi, Tatiana Kent, Katherine Sullivan-Reed, Jessica Atkins, Douglas Ralph, Margaret Nieborowska-Skorska, Anna-Mariya Kukuyan, Hsin-Yao Tang, Richard T. Pomerantz, Tomasz Skorski

Publikováno v: Nature Communications, Vol 15, Iss 1, Pp 1-18 (2024)

Abstract DNA polymerase theta (Polθ)-mediated end-joining (TMEJ) repairs DNA double-strand breaks and confers resistance to genotoxic agents. How Polθ is regulated at the molecular level to exert TMEJ remains poorly characterized. We find that Pol�

Externí odkaz: https://doaj.org/article/c0a72ae0a24344bb80638065f6025830

Discovery of a small-molecule inhibitor that traps Polθ on DNA and synergizes with PARP inhibitors

Autor: William Fried, Mrityunjay Tyagi, Leonid Minakhin, Gurushankar Chandramouly, Taylor Tredinnick, Mercy Ramanjulu, William Auerbacher, Marissa Calbert, Timur Rusanov, Trung Hoang, Nikita Borisonnik, Robert Betsch, John J. Krais, Yifan Wang, Umeshkumar M. Vekariya, John Gordon, George Morton, Tatiana Kent, Tomasz Skorski, Neil Johnson, Wayne Childers, Xiaojiang S. Chen, Richard T. Pomerantz

Publikováno v: Nature Communications, Vol 15, Iss 1, Pp 1-15 (2024)

Abstract The DNA damage response (DDR) protein DNA Polymerase θ (Polθ) is synthetic lethal with homologous recombination (HR) factors and is therefore a promising drug target in BRCA1/2 mutant cancers. We discover an allosteric Polθ inhibitor (Pol

Externí odkaz: https://doaj.org/article/a588334634d94054a3dac469d64b47e7